CHALLENGES OF HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ASSAY OF COMBINED DRUG PRODUCTS

... effects of changing the organic–aqueous ratio, the pH of the aqueous phase, the flow rate of the mobile phase and the temperature of the column on the retention time and on the shape of the AMFZ and ... One of the most important tasks of a chromatographic analyst in pharmaceutical R&D is the development of analytical methods for the assay of pharmaceutical products and validation of the methods ... Ph.D Thesis CHALLENGES OF HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ASSAY OF COMBINED DRUG PRODUCTS Éva Kalmár, Pharm.D Supervisors Prof György Dombi, Ph.D., C.Sc...

báo cáo hóa học: " Method optimization and validation for the simultaneous determination of arachidonic acid metabolites in exhaled breath condensate by liquid chromatography-electrospray ionization tandem mass spectrometry" doc

... screw-cap vial for HPLC analysis and 100 µL of the working solution of the internal standard were added to each sample Then the samples were vortex mixed and a 900 µL aliquot was injected into the LC/MS/MS ... some of the structural isomers of prostaglandins, which resulted in the same parent-daughter ion transitions The whole analytical run time, including the recondition step of the column for the ... to the slope and linearity of the calibration curve Due to the low content of matrix compounds in EBC in contrast to other matrix such as urine or plasma which could influence the response of the...

Muffler design, development and validation for pdf

... drop in an exhaust muffler plays an important role for the design and development of mufflers Prediction of pressure drop will be very useful for design and development of muffler To predict ... developed for optimum design stages and less cost for muffler design by balancing various parameters iii A practical tool to estimate quality of muffler design, which is used for concept selection and ... row and number of rows for each pattern of holes is decided The distance at which perforation starts and at which the perforation ends is also decided Thus, the design of the perforated tube for...

Development and validation of analytical method for naftopidil in human plasma by LC–MSMS

... Development and validation of analytical method for Naftopidil in human plasma by LC–MS/MS 649 for sample processing, and a high injection volume, but still no LC–MS/MS method has ... chromatograms (a) chromatogram of blank plasma, (b) chromatogram of blank + IS, (c) chromtogram of LLOQ Development and validation of analytical method for Naftopidil in human plasma by LC–MS/MS lots were ... 11.4 2.1 3.1 110.7 114.6 101.6 99.7 Development and validation of analytical method for Naftopidil in human plasma by LC–MS/MS Table 651 Inter batch precision and accuracy Quality control samples...

báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc

... designed and managed the valuation survey, analysed and reported on the valuation data and contributed to the writing of the manuscript All authors read and approved the final manuscript Acknowledgements ... state Validation of the preference based CAMPHOR scale A majority (87.8%) of the 91 participants in the CAMPHOR validation survey were in New York Heart Association (NYHA) classes II and III The ... group for use in the UK valuation of the EQ-5D For health states that a respondent regards as better than being dead, they are asked to imagine two scenarios: 1) live in a state for 10 years (t) and...

Báo cáo hóa học: " Development and validation of an Eating Disorders Symptom Impact Scale (EDSIS) for carers of people with eating disorders" doc

... disorder symptoms and behaviours of their ill relative had on their own wellbeing They were generated by a panel of clinicians and researchers based on quantitative and qualitative work with carers and ... Haigh R, Weinman J, Treasure J: Caring for people with Eating Disorders: Factors associated with psychological distress and negative caregiving appraisals in carers of people with eating disorders ... The aim of the carer workshops was to provide information and skills training for carers of people with eating disorders in order to improve their coping strategies and reduce the levels of difficulties...

báo cáo hóa học:" Development and validation of a psychosocial screening instrument for cancer" potx

... of validity Finally, raw means and standard deviations are provided for each cancer type and each gender group (Table 4) This presentational approach appeared more parsimonious and provided a ... initial data for a 3-month time period rather than setting a particular sample size as a target; the rationale for this decision was to allow us later determination what percentage of the total ... Hospital anxiety and Distress Scale PSCAN Psychosocial Screen for Cancer 18 HRQoL Health-Related Quality of Life 19 SNSA Social Network and Support Assessment Additional material Additional File...

báo cáo hóa học:" Development and validation of the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients" potx

... Development and validation of the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients ... Dry Eye SymptomBother, Dry Eye Impact on Daily Life, and Dry Eye Treatment Satisfaction, that allow a comprehensive evaluation of the burden of the dry eye condition on patients The assumption ... frequency Saturation was achieved for dry eye symptoms and these symptom sub-concepts, as well as for all of the overarching concepts of dry eye daily life impact and for the aforementioned sub-concepts...

Báo cáo y học: "Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect" pptx

... analysis and interpretation of the data, and participated in drafting the manuscript RG participated in the analysis and interpretation of the data SG contributed to the acquisition of the data ... operating characteristic curve The results of the sensitivity and specificity analyses of various cut-off points for the composite index are summarised We analysed the ability of Fibromyalgia Assessment ... widespread pain, average level of fatigue, and sleep disturbance all on one side of one page algia Assessment plot of repeatability, with the average values Bland and Altman Status values plotted against...

Báo cáo y học: "Development and validation of molecular markers for characterization of Boehmeria nivea var. nivea and Boehmeria nivea var. tenacissima" pps

... light green-grey color [8] Four collections, namely CY1 (Chi-Yi-1), CY2 (Chi-Yi-2), CY3 (Chi-Yi-3) and HCn (Hsin-Chu-n) belong to B nivea var tenacissima and the other four, namely HCd (Hsin-Chu-d), ... (CY1) and B nivea var nivea (HCd) in the ratios of 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8 and 1:9 Representative samples of the DNA ratio between B nivea var tenacissima (CY1) and B nivea var nivea ... kb for CAPS markers Ca-Afl0.30 and Ca-Afl-0.25, and 0.35 kb and 0.20 kb for CAPS markers Ca-Drd-0.35 and Ca-Drd-0.20 that could be easily visualized The species-specific patterns of CAPS markers...

báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)" pdf

... Conclusion The development and validation of the Treatment Related Impact Measure- Weight (TRIM -Weight) has been conducted according to well-defined scientific principles for the creation of a PRO measure ... debriefed version of the TRIM -Weight was incorporated into an online validation study to assess the measurement and psychometric properties of the measure As with the development phase, the validation ... generation in the development of two obesity-specific measures: the Obesity and Weight Loss Quality of Life (OWLQOL) Questionnaire and the Weight -Related Symptom Measure (WRSM) Clin Ther 2002, 24:690-700...

báo cáo hóa học: " Development and validation of a French patient-based health-related quality of life instrument in kidney transplant: the ReTransQoL" pot

... data management, analyzed and interpreted the data, drafted the manuscript; EJ participated in the design of the study, collected the data and performed the statistical analysis BD and VM: participated ... regarding the psychosocial and physical impact of kidney transplantation [4,5] Kidney transplantation is the therapy of choice for endstage renal failure when focusing on survival transplantation ... data management and the English translation of the draft References Spiker BN: Quality of life and phamarcoeconomics in clinical trials 2nd edition Philadelphia, NY: Lippincott-Raven; 1996 Ganz...

báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx

... Here 54% of the insulin- treated agreed that insulin causes weight gain, compared to 23 % in the insulin naïve The highest mean score for insulin- naïve patients was on the item pertaining to the belief ... be demanding to administer 11 Insulin means I have to give up activities I enjoy 12 Insulin means my health will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful ... < 0.001 Insulin naïve (n = 146) Mean (SD) Insulin signifies failure with pre -insulin therapy Insulin signifies diabetes has worsened Insulin will improve prognosis Insulin will make others perceive...

báo cáo hóa học: " Development and validation of the WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire (WE-CARE)" potx

... been a dearth of studies to quantitatively assess either the well-being of parents of children with type diabetes or their satisfaction with their child's diabetes regimen The paucity of information ... as of their families [3] http://www.hqlo.com/content/6/1/3 new measure: the WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire WECARE measures the psychosocial well-being ... material Additional file Appendix: The WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire The parent questionnaire upon which the study was based Click here for...

báo cáo hóa học: " Development and validation of the Brazilian version of the Attitudes to Aging Questionnaire (AAQ): An example of merging classical psychometric theory and the Rasch measurement model" pptx

... values analysis, item and subscales correlations and internal reliability analyses Exploratory and Confirmatory Factor analysis were performed to assess whether the Brazilian data fit the international ... adequate to generate reliable cross-cultural measures In conclusion, the Brazilian version of the AAQ instrument is a reliable, valid and consistent tool to assess attitudes to aging and can be ... raises the question of whether these similarities remain or not in other different cultures The demonstration of cultural invariance of the core attitudes to aging could lead to the possibility of...

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