... strongly superior to those of MTX and as well the TNF-inhibitor etanercept Most interestingly, EC0746 was markedly safer than native AMT, with a 40-fold difference in toxicity, which is explained by ... subcutaneously twice weekly showed a very good response with about 91% inhibition of paw edema and effective suppression of the systemic signs of the disease, such as weight loss and splenomegaly ... 42:1609-1616 Feldmann M, Brennan FM, Maini R: Role of cytokines in rheumatoid arthritis Annu Rev Immunol 1996, 14:397-440 Reiss AB, Carsons SE, Anwar K, Rao S, Edelman SD, Zhang H, Fernandez P, Cronstein...