Inhaled nitric oxide for treatment persistent pulmonary hypertension in the newborn

... multicenter study The INO/PPHN Study Group Pediatrics 1998;101(3 Pt 1):325 Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn Clinical Inhaled Nitric Oxide Research ... Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, Rhines J, Chang CT Inhaled nitric oxide for the early treatment of persistent pulmonary hypert...

Ngày tải lên: 14/11/2016, 06:30

... phosphodiesterase inhibitor (dipyridamole) [16] Study of the mechanism of INO dependency may give insight into new therapies that augment the pulmonary vasodilatory effect of INO and the activity of the endogenous ... of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn Pediatrics 1996, 98:706–713 12 The Neonatal Inha...

Ngày tải lên: 12/08/2014, 18:20

... Hyaluronan modulates accumulation of hypoxia -inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model Arthritis ... mirrors much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and des...

Ngày tải lên: 12/08/2014, 17:21

... compliance and airway resistance, and the response of these parameters to inhaled NO Our preliminary results demonstrated that cell-free hemoglobin-induced pulmonary hypertension and decreased lung ... selectively reverses pulmonary hypertension and decreased lung compliance induced by cell-free hemoglobin blood substitutes Acknowledgements The authors thank...

Ngày tải lên: 12/08/2014, 18:20

... into the inspiratory limb; iy = sequential administration into the Y- piece; ci = continuous administration into the inspiratory limb; cy = continuous administration into the Y piece Published ... pulmonary diffusing capacity with nitric oxide and carbon monoxide Eur Respir J 1989, 2:56-63 doi:10.1186/cc118 Cite this article as: Puybasset and Rouby: Equipment review: P...

Ngày tải lên: 12/08/2014, 18:20

... oxygenation, but it may also provide potent anti-inflammatory effects [23] Here we report a case of severe traumatic brain injury with dramatically elevated intracranial pressure in the setting of ... efforts at combating inflammation The use of INO in this report was for emergent and compassionate use in the setting of critically elevated intracranial...

Ngày tải lên: 13/08/2014, 23:20

... morphological criteria The murine macrophage cell line RAW264.7, originally from the American Type Culture Collection (Manassas, VA, USA) and maintained in our laboratory, was also used For cell ... antibody pairs A 96-well EIA/RIA plate (Corning Inc.), coated with a coating antibody and masked with skim milk, was incubated with test samples and standard solutions A biotin...

Ngày tải lên: 17/03/2014, 10:20

... Comparative changes in (a) mean pulmonary artery pressure (∆MPAP) and (b) pulmonary vascular resistance index (∆PVRI) induced by increasing inspiratory intratracheal concentrations of inhaled ... hemodynamic and respiratory paramaters were measured at the same ventilator settings as in phase Statistical analysis Cardiorespiratory parameters at control were compared between groups us...

Ngày tải lên: 12/08/2014, 18:20

... neuronal serotonin (5-HT) reuptake, but also trigger indoleamine release has sparked renewed interest for the serotonin hypothesis’ of PH In our laboratory, we recently tested the hypothesis that the ... encoded by a single gene [14] These facts initially led to the hypothesis that fenfluramine-like medications may elevate circulating 5-HT levels [15,16], which in turn ma...

Ngày tải lên: 12/08/2014, 18:20

... solution the hypothesis that this combination prevents intrapulmonary shunt more effectively than does either intervention alone, and that it reduces inactivation of surfactant substitutes In summary, ... death and infection of the donor lung, reduced surfactant function is aggravated by preservation of the graft, ischaemia and reperfusion Therefore, substitution o...

Ngày tải lên: 12/08/2014, 18:21

... behind this study was based on the findings that angiotensin converting enzyme and angiotensin II are both involved in the pulmonary vascular remodelling associated with hypoxic pulmonary hypertension ... 23(89):57-72 Yu PN, Lovejoy FW Jr, Joos HA, Nye RE Jr, McCann WS: Studies of pulmonary hypertension I Pulmonary circulatory dynamics in patients with pulmonary emphysem...

Ngày tải lên: 12/08/2014, 18:22

... the present study suggests that iNO may influence clinical outcomes as well This should be a consideration in our armamentarium in the battle against AHRF The recognition that AHRF is often the ... [2] Acute hypoxic respiratory failure (AHRF) encompasses acute respiratory distress syndrome and acute lung injury and remains a significant cause of death in t...

Ngày tải lên: 12/08/2014, 20:20

... 0.05 between baseline and before INO Endotoxin also caused a rapid release of inflammatory mediators and vasoactive substances Prostanoids, LTB4, ET-1, nitrates and cytokines increased in the ... levels of the proinflammatory cytokine IL-8 followed the endotoxin evolution in blood Endothelin-1 and inhaled nitric oxide The ET-1 in plasma rose rapidly and marke...

Ngày tải lên: 13/08/2014, 11:23

... R, Ullrich R: Inhaled nitric oxide therapy in adults: European expert recommendations Intensive Care Med 2005, 31:1029-1041 Griffiths MJ, Evans TW: Inhaled nitric oxide therapy in adults N Engl ... survey of the use of inhaled nitric oxide in the ICU Working Group on Inhaled NO in the ICU of the European Society of Intensive Care Medicine Intensive Care Med 199...

Ngày tải lên: 13/08/2014, 15:22

... COMPOSITE CONTROLLED RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE ... illustration of the proposed composite controlled release system of NO is depicted in Figure 1-1 There are three main parts in the composite system: supportiv...

Ngày tải lên: 10/09/2015, 09:08