... (PREDict MUTants) , was developed for prediction of the severity of p53 mutants The method was trained on a set of known mutants and subsequently evaluated on another set The method is based on parameters ... À yÞ2 where x and y are values from the two parameters measured, and x and y are the mean values for the respective parameters Thermally sensitive mutants There are several p53 mutants whose ... singlenucleotide mutations affecting the central domain of p53 For each variant, the values of all parameters used in the severity prediction are given On the basis of these values, a severity score is presented,...