... tissue hypoxia, disease severity, and is a strong and independent predictor of mortality [20] However, the exact time course of Ang-2 release during sepsis and the role of inflammatory cytokines ... investigated in human sepsis To address these issues, we wanted to study the time course of Ang-2 release, and the association of Ang-2 with soluble adhesion molecules and inflammatory cytokines in ... the infusion of lipopolysaccharide (LPS), the volunteers received a single oral dose of RWJ-67657 (4-(4-(Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyrindinyl)-1H-imidazol-2-yl)-3-butyn-1-ol), supplied...