PTI recommendations for stay cable 2007

... rệt theo hướng công khai, minh bạch tạo thuận lợi cho người dân, doanh nghiệp; + Bộ máy hành hoạt động hiệu (do tinh gọn hơn, cấu bên phân định rõ hơn, công khai, minh bạch hơn, quyền làm chủ ... công nghệ thông tin hoạt động quan hành nhà nước b) Ứng dụng công nghệ thống tin xử lý quy trình công việc nội quan hành c) Công bố danh mục dịch vụ hành công môi trường mạng thông tin điện tử quan ....

Ngày tải lên: 24/10/2012, 09:05

... discrepancy problem and facilitate international trade activities using L/C product Aims of the study This study, An analysis of key changes in UCP 600 compared to UCP 500 and Recommendations for better ... II: Key changes under UCP 600 in comparison to UCP 500 , points out structural changes as well as key changes in UCP 600 in compari...

Ngày tải lên: 27/10/2012, 16:40

... in building, managing and protecting its brand equity, especially in two elements Brand Awareness and Perceived Quality Building and Managing Brand Equity 1.1 Building Customer- Based Brand Equity ... BUILDING, MANAGING AND PROTECTING BRAND EQUITY FOR A BUSINESS Trng Thu Chi- CQ503891- Business English 50A Brand equity 1.1 Definition Brands var...

Ngày tải lên: 24/07/2013, 15:00

... techniques, principally in the form of high-performance liquid chromatography (HPLC) / MS (LC/MS), mass spectrometry has become the principal method of mixture analysis in pharmaceutical research and ... ions Clearly, the ion formation process is separated from solvent evaporation process in APCI (in contrast to ESI), allowing the use of solvents unfavorable for ion formation For exampl...

Ngày tải lên: 15/12/2013, 12:15

... metabolites are important biotransformation pathways for many drugs and xenobiotics [127, 132, 133] For example, the formation of acyl glucuronide conjugate forced the withdrawal of four marketed ... was achieved for the exact mass measurements, using PEG sulfates as internal calibration substance Based on the high-resolution MS information, empirical formulae were obtained for all co...

Ngày tải lên: 15/12/2013, 12:15

... sometimes the ACD prediction of the solubility for the ionized form of bases and acids shows greater deviation than for the solubility predicted for the neutral form of the molecules Reaction of the excipients ... ACD prediction versus HPLC experimental results for the solubility of a basic compound for these studies Fast gradient methods on short columns are usually used in most...

Ngày tải lên: 15/12/2013, 12:15

... by the pressure limitation of the HPLC equipment For more information on gradient separation and developing fast HPLC methods, see Chapter 17 and Practical HPLC Method Development from Synder ... respective analytical method that is applied to a real in-process sample or a dosage form for subsequent HPLC analysis The analytical procedure must specify the manufacturer, type of filte...

Ngày tải lên: 15/12/2013, 12:15

... peak height) for peak B ≤ 1.5 Tailing factor (5% peak height) for peak A ≤ 1.5 Rt for peak A must be 12.0 ± 1.3 Rt for peak B must be 21 ± 1.0 The S/N of the LOQ solution (0.05%) for both actives ... acetonitrile The experiments for w pH 2–4 were performed on day w 1, and those for w pH 5–7 were performed on day (≈36 hr after initial prepaw ration) A further investigation was pe...

Ngày tải lên: 15/12/2013, 12:15

... analyte pKa shift) for both basic ionization centers Therefore this cors relates with a spKa of 2.7 for pyridinal nitrogen (i.e., 3.3 − 0.6 = 2.7) and with s a spKa of 4.7 for the morpholinal ... is in its neutral form No lower METHOD DEVELOPMENT APPROACHES 411 limit plateau is observed where the analyte would be in its fully ionized form Therefore, further analysis for this compound...

Ngày tải lên: 15/12/2013, 12:15

... isocratic conditions for determining the most suitable pH for the method The retention behavior of active as a function of pH (isocratic) was determined The best mobile-phase pH for further gradient ... AMDS/Dry Lab for method optimization and then use MS to confirm the separation of active species from possible co-eluting species MS/MS analysis can 426 METHOD DEVELOPMENT be performed...

Ngày tải lên: 15/12/2013, 12:15

... NORMAL-PHASE SEPARATIONS Reversed-phase HPLC is the dominant method used for the majority of pharmaceutical applications (>95%) Normal-phase chromatography may be required for separations that are not compatible ... crystals that will damage the seal over time Therefore it is recommended to wash the HPLC system with acetonitrile/water (20 : 80) for at least 30 before the system is...

Ngày tải lên: 24/12/2013, 18:15

... three basic types of molecular forces: ionic forces, polar forces, and dispersive forces Each specific technique capitalizes on each of these specific forces: Polar forces are the dominant type of ... normal-phase HPLC (see Chapter 5) Dispersive forces are employed in reversed-phase HPLC (see Chapter 4) Ionic forces are employed in ion-exchange HPLC (see Chapter 4, Section 4.10) The fourt...

Ngày tải lên: 24/12/2013, 18:15

... ( c s ) = K H K p ce (2-66) 56 HPLC THEORY where KH is a Henry adsorption constant The final form of the distribution function, accounting for v0 = vm + vs, therefore will be ψ (ce ) = [v0 + ( ... nonionic form of the analyte at conditions where protonation is completely suppressed Corresponding capacity factors for neutral and protonated forms of basic analyte could be written in the fo...

Ngày tải lên: 24/12/2013, 18:15

... in HPLC are porous particles with average diameters between and 10 µm For most pharmaceutical applications, 3-µm particle sizes are recommended Porosity provides the surface area necessary for ... compounds) could play a major role All these factors are the driving force for the search in alternative base materials for HPLC packings 90 STATIONARY PHASES The majority of polymer-...

Ngày tải lên: 24/12/2013, 18:15