Proteomic analysis of the response of murine bone marrow derived macrophages to IFN y stimulation and infection with staphylococcus aureus

... stimulation by distinct inflammatory injuries [3,44] EPC have been shown to display a higher proliferative potential [45] and may migrate to regions of the circulatory system with injured endothelia, including ... hypothesis whether the homing of intravenously administered bone marrow- derived EPC occurred in damaged lung tissue after the setting of severe tissue injury,...

Ngày tải lên: 12/08/2014, 15:20

... protein components of the epithelial lining fluid of the airways and alveoli Distinct change in certain protein levels in BAL fluid has been correlated to allergic airway inflammation Many investigations ... staining for fibronectin 113 27 Representative 2-D gels in chronic asthma model 120 28 Protein grouping using Gene Ontology Annotation 124 29 Interactions between actin bi...

Ngày tải lên: 14/09/2015, 22:03

... Other kinases, such as casein kinase I and II, protein kinase A, 38 CDK7, DNA-activated protein kinase, and Jun-NH2 kinase (JNK), also mediate phosphorylation of p53 and play important roles in ... that in turn “protects” radiation-damaged DNA from restoring to an undamaged state Stable DNA damage accumulates and leads to an increased lethality from a given dose of radiat...

Ngày tải lên: 16/09/2015, 15:43

... intravenously injected into nude mice and the distribution and migration of MSCs were dynamically monitored to evaluate the feasibility and safety of intravenous implantation of allogeneic MSCs in the ... transplanted the bone marrow stem cells into the necrotic femoral heads, and results show bone marrow stem cells can remove vascular lesions...

Ngày tải lên: 25/10/2012, 11:18

... molecules in the course of hypoxia-induced apoptotic pathways Such analysis of trophoblastic cells will, in the near future, yield insights into the mechanisms of preeclampsia and other hypoxia-related ... and by modulating phosphorylation of JNK In conclusion, various pro- and antiapoptosis-related proteins were expressed in the process of hypoxia-induced apoptos...

Ngày tải lên: 31/10/2012, 15:12

... immunoglobulin chains were also found to be significantly increased in aged thymocytes Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte fate ... the increased levels of many of these genes identified in the array analysis Moreover, Western blot analysis of thymocyte lysates also confirmed that IgM increas...

Ngày tải lên: 03/11/2012, 11:35

... overexpressing a- synuclein A proteomic analysis is expected to identify cellular alterations that are associated with dopamine treatment and modulated by a- synuclein overexpression, without any a priori ... eukaryotic initiation factor 5A (eIF 5A) , parathymosin, L7 ⁄ L12, annexin A2 , annexin A5 , aldolase A, fascin and peroxyredoxin 1] displayed quantitative diff...

Ngày tải lên: 15/02/2014, 01:20

... represented in the AML samples Intra-individual analysis of the spot patterns showed a high correlation between the sample from peripheral blood and bone marrow (Table 2) On/off-phenomena of the identified ... Expression of the plasminogen activator inhibitor-2 (PAI2) was only found in patients E and F with the subtyp FAB M0 and M4, respectively T...

Ngày tải lên: 18/06/2014, 15:20

... of the sterility testing in compliance with eu Pharmacopoeia 2.6.1 (sterility) and the validation of the potency assay in an ATMP that is constituted of bone- marrow mononucleated cells used in ... using cell systems and in vivo assays using animal models As concerning the use of bone marrow mononucleated cells in cardiac repair, the...

Ngày tải lên: 18/06/2014, 15:20

... an increased risk of developing BMLs after adjusting for energy intake (Table 2, model 1) For each SD increase in dietary intake of saturated fatty acids, the risk of developing BMLs over years ... important in maintaining joint integrity and the development of OA, this study suggests that dietary modification of fatty acid intake may be one strategy in...

Ngày tải lên: 09/08/2014, 14:20

... overexpressed in BxPC-3 cells whereas phosphoglycerate kinase was over-expressed in AsPC-1 cells, which agrees to the results obtained by the proteomic approach Discussion Metastasis is a highly ... lymphangiogenesis and lymphatic metastasis in PDAC cells [29] The described proteomic approach is reproducible for analysis of membrane proteins in cultured pancreatic cancer c...

Ngày tải lên: 10/08/2014, 05:21

... Dou KF, Yang GS, Willerson JT, Geng YJ: Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts Arterioscler Thromb Vasc Biol ... neovascularization in murine hindlimb ischemia by combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells transplan...

Ngày tải lên: 10/08/2014, 05:21

... enrichment of Lin- PCs in the pneumonia lungs Few of these Lin- PCs migrated into the airspaces (approximately 3.1% of all the cells remaining in the lung) , therefore approximately 14.6% of the initially ... shown in the BM homing study by Szilvassy and colleagues [38]), increasing the number of infused progenitor cells will increase the number of...

Ngày tải lên: 12/08/2014, 15:21

... Expression of genes in the BMP2+ cells associated with plasticity, and mesodermal and NCSC phenotypes BMP2+ cells are still in a state of plasticity BMP2+ cells significantly upregulate Oct4 and Nanog ... 50 µm 20 µm Analysis neural crest stem cell associated transcripts in BMP2+ cells Figure of Analysis of neural crest stem cell associated transcripts in...

Ngày tải lên: 14/08/2014, 08:20

... study and two proteomics datasets published recently [10,11] Catalytic 305 Figure GoMiner analysis of the molecular function of identified proteins GoMiner analysis of the molecular function of ... can be estimated very roughly by the number of peptides identifying each protein (or more accurately by the number of peptides observed divided by the number of theoretically ob...

Ngày tải lên: 14/08/2014, 16:21