... a monoclonal anti-porphyrin Ig, with an iron( III)-DoCPP cofactor and imidazole as an axial ligand of the iron which, respectively, mimick the heme cofactor and the axial histidine ligand of the ... Binding of imidazoles to the iron( III) of Fe(ToCPP) and Fe(ToCPP))13G10 The second part of our results concerns the binding of imidazole derivatives on...
Ngày tải lên: 21/02/2014, 03:20
... segment of this domain is critical for high affinity agonist binding but not antagonist binding [14] The corresponding residue in the OTR is also an arginyl (Arg34) and furthermore this arginyl is ... V1aR [10] The role of the N-terminus has been addressed recently by alanine-scanning mutagenesis of the N-terminus of the V1aR; this revealed that a sing...
Ngày tải lên: 07/03/2014, 21:20
An Anatomy of Economic Inequality in the UK – Summary docx
... wider in London than in any other region, and inequality in earnings and incomes has increased faster in London over the last decade than anywhere else Table S3: Inequality in earnings and income ... the main report for discussion of the highest incomes and earnings An anatomy of economic inequality in the UK Overall inequalities Figure S1 shows what thes...
Ngày tải lên: 08/03/2014, 06:20
Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot
... designed to maintain hydrophobicity and Gly, Ser, Asp and His mutants to provide hydrophilicity The catalytic roles of Cys341 in carboxypeptidase Y are examined by comparing the kinetic parameters of ... involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1 subsite induced...
Ngày tải lên: 08/03/2014, 23:20
Research "An empirical study of scale economies in the Chinese Railway System" pptx
Ngày tải lên: 16/03/2014, 03:20
Selective Distribution of Luxury Goods in the Age of e-commerce An Economic Report for CHANEL doc
... reduce the value of the product to the customer 50 The “image” of a brand is therefore an integral part of the product, and determines the willingness to pay of consumers Manufacturers of luxury goods ... uncertainty as to whether an internet offering critically undermines the luxury image that is central to many products in the luxury goods industry...
Ngày tải lên: 16/03/2014, 09:20
An update to the World Bank’s estimates of consumption poverty in the developing world* pot
... For the first time since this monitoring task began, the data indicate a decline in both the poverty rate and the number of poor in all six regions of the developing world Between 2005 and ... in 1981 The developing world as a whole has already attained the first Millennium Development Goal of halving the 1990 incidence of extreme poverty by 2015 ...
Ngày tải lên: 29/03/2014, 09:20
Temi di discussione: An empirical analysis of national differences in the retail bank interest rates of the euro area doc
... PICCININI AN EMPIRICAL ANALYSIS OF NATIONAL DIFFERENCES IN THE RETAIL BANK INTEREST RATES OF THE EURO AREA by Massimiliano Affinito * and Fabio Farabullini* Abstract The availability of new ... for the national factors influencing the level of interest rates The final section summarizes our findings The data and a descriptive analysis of...
Ngày tải lên: 29/03/2014, 13:20
INTERNATIONAL STANDARD ON AUDITING 200 OVERALL OBJECTIVES OF THE INDEPENDENT AUDITOR AND THE CONDUCT OF AN AUDIT IN ACCORDANCE WITH INTERNATIONAL STANDARDS ON AUDITING doc
... 10–11, and 16 ISA 200 86 OVERALL OBJECTIVES OF THE INDEPENDENT AUDITOR AND THE CONDUCT OF AN AUDIT IN ACCORDANCE WITH INTERNATIONAL STANDARDS ON AUDITING • The drawing of conclusions based on the audit ... OVERALL OBJECTIVES OF THE INDEPENDENT AUDITOR AND THE CONDUCT OF AN AUDIT IN ACCORDANCE WITH INTERNATIONAL...
Ngày tải lên: 29/03/2014, 18:20
Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc
... control substance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23] We hypothesized that an increase in steady-state ... Cyclosporin A-induced oxidative stress M van der Toorn et al calcineurin therefore play a role in cyclosporin A-induced oxidative stress and disturbed C...
Ngày tải lên: 30/03/2014, 08:20
Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot
... that is bound within the vicinity of the active site Further investigation is required to determine if protein crystallization of human TDP were carried out in the presence of manganese, manganese ... Topo I enzyme and its DNA substrate during catalysis in the presence of Topo I inhibitors such as camptothecin Inhibitors of the human TDP might potentiate or...
Ngày tải lên: 31/03/2014, 21:21