... Research on Cancer as a human carcinogen From a biochemical standpoint, PCDDs, PCDFs, and PCBs appear to cause their toxic effects through chemical binding to a specific cellular receptor known ... damage Concerns from chronic exposure to dioxins include cancer, reproductive effects, and developmental effects The most toxic dioxin congener, TCDD, was classified by the International Agency for ... pituitary–hypothalamic–thyroid axis by perchlorate may lead to serious effects, such as carcinogenicity, neurodevelopmental and developmental changes, reproductive toxicity, and immunotoxicity Specific concerns...