... potencies in vivo of hCt, sCt, analogues 1–6 and/ or the partial sequence analogues 1a, 1b, 2a, and 3a The CD data of the partial sequence analogues 1a, 1b, 2a, and 3a are presented, because there were ... conformation in the region 17–21 may play an important role in hCt bioactivity and showed that the conformation and the topological features of the side chains of amino acid residues 18 and 19 are ... regression analyses of the data using the software PRISM (GraphPad Software, Inc.) RESULTS AND DISCUSSION Design of the analogues A b turn conformation strongly depends on the nature and chirality of the...