Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood...
báo cáo khoa học: "Feedback GAP: study protocol for a clusterrandomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care" pdf
... this article as: Ivers et al.: Feedback GAP: study protocol for a cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary ... feedback to explore the barriers and facilitators to Ontario family physicians’ acceptance and utilization of performance feedb...
Application of biologically active micelles in drug delivery across the blood brain barrier
... overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain barrier (BBB) is the rule, not the exception ... 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000)...
Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... determined with the free somatic form using inhibitor profiles (Tables and 2) validates the use of selective inhibitors as convenient tools to study the specificity of the somatic form of ACE Thus, ... were applied to the atomic position of several sets of atoms The harmonic constants were set to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and t...
báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the bloodbrain barrier is mediated by luminal microvessel IL-6 and GM-CSF 1,2,3 Shinya Dohgu 2,3,4 , Melissa A Fleegal-DeMotta ... permeability of the BMEC monolayer as measured by TEER is not mediated by extracellular IL-6 and GM-CSF We further investigated this functional polari...
Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... directly induce a disruption of the BBB in vitro [54] Thus, these mediators interact with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity ... integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the antibody-mediated blockade of anaphylatoxin C5a prevented bre...
Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DELIVERY OF DIAGNOSTIC/ THERAPEUTIC AGENTS: THEIR POTENTIAL APPLICATION IN BRAIN CANCER THERAPY YU QIANRU (B.Eng, Southeast ... Limitations in Modern Chemotherapy 2.2 Brain Cancers and Blood Brain Barrier (BBB) 2.2.1 Brain cancers and cancer treatment 2.2.2 Introduction to the blood brain barrier 2.2.2.1 H...
Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS BY LEE SIE HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carri...
Nanomedicine multifunctional nanoparticles of biodegradable polymers for cancer treatment
... NANOMEDICINE: MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER TREATMENT LIU YUTAO (B.Sc., Fudan University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... development of cutting-edge nanoparticles of biodegradable polymers with overall fascinating performance demonstrates the progress in the field of nanomedicine for ca...
Multifunctional nanoparticles of biodegradable polymers for diagnosis and treatment of cancer
... MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS AND TREATMENT OF CANCER PAN JIE (M ENG., TIANJIN UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging for cancer diagnosis at its early stage Two polymers of...
Trastuzumab decorated nanoparticles of biodegradable polymers for targeted small molecule chemotherapy
... (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer Biomaterials 2008; 29(4): 475-486 Sun B, Feng SS Trastuzumab decorated nanoparticles for targeted chemotherapy ... conjugation of trastuzumab on NP surface for targeted drug delivery Experiments were carried out to investigate the feasibility of the obtained NPs fo...
Paclitaxel loaded nanoparticles of biodegradable polymers for cancer chemotherapy
... PACLITAXEL LOADED NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER CHEMOTHERAPY KHIN YIN WIN (M Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL ... potential analysis of various formulations of paclitaxel- loaded PLGA nanoparticles 81 Figure 13 XRD analyses of paclitaxel, TPGS, blank PLGA nanoparticles and p...
Nanoparticles of biodegradable polymers for gene therapy of hepatitis b
... DNA: NANOPARTICLES < /b> OF < /b> BIODEGRADABLE < /b> POLYMERS < /b> FOR < /b> GENE < /b> THERAPY < /b> OF < /b> HEPATITIS < /b> B JUNPING WANG (B Eng., ZJU, China) A THESIS SUBMITTED FOR < /b> THE DEGREE OF < /b> MASTER OF < /b> SCIENCE GRADUATE PROGRAM IN BIOENGINEERING ... gastrointestinal (GI) barrier and blood brain barrier, thus can benefit oral gene < /b> delivery and b...
báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... Conclusion: The therapeutically relevant upper limit of blood-brain tumor barrier pore size is approximately 11.7 to 11.9 nm Therefore, effective transvascular drug delivery into malignant glioma ... as effective transvascular drug delivery devices for the sustained-release of chemotherapeutics into malignant glioma cells Even though fenestrations and gap...
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