Mechanisms of hypochlorous acid mediated neuronal cell death

... levels of NO produced by the endothelial isoform of this enzyme are beneficial by, among other mechanisms, sustaining blood flow in the periphery of the ischemic brain On the other hand, under normal ... effective therapeutic agents During the last decade a great deal of interest has been devoted to dissecting the role of the endocannabinoid system in physiolo...

Ngày tải lên: 07/03/2014, 03:20

... defence regulatory function 4668 Fig Role of EDS1 ⁄ PAD4 ⁄ SAG101 and BON1 ⁄ BAP1 + in cell death and plant pathogen resistance Whereas EDS1, PAD4 and SAG101 are positive regulators of cell death, ... underscores the role of salicylic acid (SA) and jasmonic acid (JA) 4672 WRKY53 that differentially accumulate during leaf senescence [123,124] Targets of...

Ngày tải lên: 16/03/2014, 02:20

... neuronal death FEBS J Teixeiro E & Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation ... ERK- mediated cell death: sustained and sequestered activity ROS as mediators of ERK- induced cell death In the majority of the studies rela...

Ngày tải lên: 29/03/2014, 08:20

... protein APLP2 by the disintegrin and metalloproteinases ADAM10 and TACE (ADAM17), and a common upregulation of ADAM10 and its substrate by RA The main criteria for the involvement of ADAMs, the ... cells, the amount of the pro- and the mature form of this proteinase even decreased in SKNMC cells, revealing reduced stability compared with ADAM...

Ngày tải lên: 30/03/2014, 11:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cel...

Ngày tải lên: 18/06/2014, 19:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In...

Ngày tải lên: 20/06/2014, 03:20

... altogether in the other constructs (B) amino acid sequence of the carboxyterminus of wildtype Bcl-2, Bcl-2 ActA, Bcl-2 cb5 and Bcl-2 ΔTM The amino acids derived from ActA and cb5 are shown in bold ... [15,35]) Alternatively, the exclusive protection by wildtype Bcl-2 may be explained by a combined requirement of Bcl-2 at both mitochondria...

Ngày tải lên: 09/08/2014, 10:20

... Cite this article as: Faria et al.: The NAC domain-containing protein, GmNAC6, is a downstream component of the ER stress- and osmotic stress-induced NRP-mediated cell-death signaling pathway BMC ... statistical analysis of the data and drafted the manuscript MTBR and PABR assisted directly the qRT-PCR assays and the caspase 3-like activit...

Ngày tải lên: 11/08/2014, 11:21

... shown) Cell viability Cell viability was assayed in SHK-1, TO and ASK cells infected with ISAV 2, 4, or 10 during the course of infection (days 1, 3, 5, and 9) using the Cell Titer Blue assay The ... role in the innate cellular responses to limit virus infection [14] Influenza virus is reported to induce apoptosis in vivo and in vitro [15-18] Upon activation...

Ngày tải lên: 12/08/2014, 04:21

... unraveling the role of EDR2 in restricting cell death in plant-pathogen interactions Conclusion EDR2 was isolated as a negative regulator of cell death, specifically the cell death elicited by ... between edr2- 6 and wild type suggested that the edr2- 6 mutation was linked to a single T-DNA insertion, and that both the disease resistance and the lesion phenotypes o...

Ngày tải lên: 12/08/2014, 05:20

... I.5 Na+- H+ Exchanger (NHE) The Na+- H+ exchangers (NHEs) are a family of membrane glycoproteins which transport H+ out of the cell in exchange for Na+ with a stoichiometry of 1: 1 In mammalian cells, ... increased 11 2 susceptibility to cell death IV .12 Regulation of intracellular pH as one of the mechanisms of 11 3 NHE- 1 -mediated cell...

Ngày tải lên: 16/09/2015, 08:31

... of c-Jun, c-Fos and ATF2 29 1. 3 .1. 3 Regulation of AP- 1 activity by its interacting proteins 30 1. 3.2 Role of AP- 1 in cell proliferation and differentiation 31 1.3.2 .1 Role of AP- 1 in ... AP- 1 in cell proliferation 31 1.3.2 .1. 1 AP- 1 is an important regulator in cell proliferation 31 1.3.2 .1. 2 Mechanisms of AP- 1 modulation of...

Ngày tải lên: 16/09/2015, 15:54

... despite the many morphological and biochemical studies of PCD in protozoan parasites, most of the homologs of mammalian molecules involved in cell death signaling are missing in the protozoa and the ... Furthermore, by dissecting the mechanisms and regulation of the staurosporine-induced cell death pathway in Blastocystis may lead to discovery of n...

Ngày tải lên: 16/10/2015, 15:35

... to the death of neurons (Ekshyyan and Aw, 2004) 1.1.1 Types of cell death: apoptosis and necrosis Mammalian cells can die by one of several different defined pathways, the most common of which ... of all animal cell types Originally, they are thought as involved only in the digestion of cell nutrients, cell protein turnover, tissue remodeling, lysis of invaders, and a...

Ngày tải lên: 10/11/2015, 12:35