EVOLUTION OF PROTEIN PROTEIN INTERACTION NETWORKS IN DUPLICATION DIVERGENCE MODEL

... Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (199 9) Dual targeting property of the N-terminal signal sequence of P450 1A1 Targeting of heterologous proteins to ... open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP 1A1 requiring N-terminal truncation, w...

Ngày tải lên: 18/02/2014, 16:20

... Predicting protein–protein interaction sites (Eur J Biochem 269) 1357 More recently, methods were devised for predicting residues involved in protein interaction sites in the absence of any structural ... (1997) Analysis of protein–protein interaction sites using surface patches J Mol Biol 272, 121–132 14 Jones, S & Thornton, J.M (1997) Prediction of protein–prote...

Ngày tải lên: 21/02/2014, 15:20

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inh...

Ngày tải lên: 22/02/2014, 04:20

... with the patterns of binding of Nrl to the rhodopsin promoter (Fig 4C,D) The mRNA transcript levels of Ppp2r5c and rhodopsin in mouse retina corresponded to the observed increase in Nrl binding ... Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A Science 283, 2089–2091 16 Li X, Yost HJ, Virshup DM & Seeling JM (2001) Protein...

Ngày tải lên: 06/03/2014, 02:20

... number of protein protein interactions ⁄ number of complexes (inter ⁄ comp.), while the STRING search results are presented as number of protein protein interactions (inter.) only Proteins are ... contained regions of intrinsic disorder One example of an ordered hub, calmodulin, makes use of a flexible hinge to facilitate binding diversity Each of these classes and thei...

Ngày tải lên: 07/03/2014, 21:20

... FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur J Biochem 269) 1051 Fig Scheme of the major insulin signaling pathways The activated insulin receptor phosphorylates tyrosine residues ... FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur J Biochem 269) 1059 89 Dadke, S., Kusari, J & Chernoff, J (2000) Down-regulation of insulin s...

Ngày tải lên: 17/03/2014, 23:20

... calcium-activated K+ channel, large-conductance Ca2+and voltage-regulated K+ channel, hyperpolarizationactivated cyclic nucleotide gated channel, ether-a-go-go and cyclic nucleotide-gated channel ... sites at the cytosolic face of KAT1 (B) Changes in the current amplitudes of the different KAT1 mutants after PMA application The characteristics of WT KAT1 in the...

Ngày tải lên: 22/03/2014, 21:21

... completeness of information obtained from abstracts in comparison to the full-length articles as a measure of reliability of abstracts as sources of protein interaction data METHODS Selection of articles ... (proprietary protein interactions maps database from Jubilant Biosys Ltd.) was used IMaps is a manually curated database with more than 200 000 protein- protein,...

Ngày tải lên: 22/06/2014, 19:20

... repeated over 100 random trials, in which the interactions of both networks are reassigned while maintaining the same number of interactions per protein, resulting in a distribution of random subnetwork ... simple cutoff in the number of interactions Genetic interactions are usually robust, so the distinction by interaction number is less critical Protein interactions on the...

Ngày tải lên: 06/08/2014, 18:21

... Therefore, rather than fragmenting the network, the removal of nodes and links in the Buchnera network maintains the global topology of the network, preserving the main interaction backbone The prefer- ... within the interaction network are important in the reductive process Accordingly, the importance of the roles of the proteins must be taken into c...

Ngày tải lên: 14/08/2014, 07:21

... hypothetical protein- protein interaction network Each sphere represents a protein and the connecting lines represent protein- protein interactions Within an interaction network, smaller local interaction ... and independently fusing these domains with candidate interacting proteins [21,22] Constructs encoding these fusion proteins are transformed into yeast cells; if the two...

Ngày tải lên: 14/08/2014, 14:21

... ataxia-causing protein Y2 H prey Interaction from hORFeome Interaction from cDNA library Figure An interaction network of proteins involved in spinocerebellar ataxias The yeast two-hybrid interaction data ... modifiers confirming interactions and then assessing whether they modulate the functions of the wild-type or disease proteins Indeed, this has been demonstrated for on...

Ngày tải lên: 14/08/2014, 17:22

... shown previously that duplication of protein interactions and of entire protein complexes is accompanied by specialization of function [9] Inspection of the effects of duplication of homo-interactions ... coefficient (C) of a network as a descriptor of the extent of modularity of that network Clusters frequently correspond to known protein complexes, as show...

Ngày tải lên: 14/08/2014, 20:22

... pressure [3,8] These drives for combinatorial rearrangement, together with the defining modular property of domains, enable the construction of increasingly complex sets of proteins [9] In other words, ... evolutionary definition of protein domains [3] as regions of a protein sequence that are highly conserved The (interdependent) structural and evolutionary definitions...

Ngày tải lên: 14/08/2014, 21:20

... 1.2 Intrinsic Protein Disorder in Protein- Protein Interactions Many proteins execute their biological functions through protein- protein interactions By binding to interacting partners, proteins ... 1: Introduction 1.1 Intrinsic Protein Disorder and Protein Functions .1 1.2 Intrinsic Protein Disorder in Protein- Protein Interactions 1.3 Characterization of Molecular Rec...

Ngày tải lên: 24/08/2014, 09:56