Role of hepatocyte nuclear factor 4a in the kidney

... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên: 16/02/2014, 09:20

... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... rather than functional role Role of hydrophobic contacts in serine hydroxymethyltransferase In the present study, the importance of the third hydrop...

Ngày tải lên: 07/03/2014, 03:20

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên: 08/03/2014, 08:20

... of glycogen in the intact liver in vivo Second, during infusion of [1-1 3C ]glucose, label incorporation was observed not only into the C1 of glycogen but also the C6 , which can only occur by label ... a mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increas...

Ngày tải lên: 17/03/2014, 17:20

... Role of HNFs in transthyretin gene expression Z Wang and P A Burke Fig Mutation of the HNF binding site mainly disrupts the corresponding HNF binding ability, and not that of other HNFs Nuclear extracts ... treatment with cytokines HepG2 cells were treated with or without cytokines for 18 h The interaction of HNF protein with the DNA binding site was determined by ChIP assay...

Ngày tải lên: 23/03/2014, 03:20

... homodimer interface of HNF-4a contributing to the stability of the interface [11] The assignment of helices H3–H12 based on the crystal structure of HNF-4a, together with the point mutations of amino ... Ladias J (1997) Functional domains of the nuclear receptor hepatocyte nuclear factor J Biol Chem 272, 539–550 Hall RK, Scott DK, Noisin EL, Lucas PC & Granner DK (1992...

Ngày tải lên: 23/03/2014, 10:21

... monophosphate kinases L Wang supply of nucleoside monophosphates may regulate the synthesis of nucleoside di- and triphosphates In Mollicutes, other enzymes exist that are capable of synthesizing nucleoside ... purification of Ureaplasma nucleoside monophosphate kinases Primers used in PCR amplification of Ureaplasma nucleoside monophosphate kinases...

Ngày tải lên: 30/03/2014, 08:20

... responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin In addition, our data suggest that insulin stimulates cell division, in bovine thyroid cultures, ... significant increase in concentration of the peroxidase inhibitor by the action of insulin, during 48 h, in thyroid primary cultures with 0....

Ngày tải lên: 30/03/2014, 14:20

... noitazidirbyherp eht gniniatnoc erutxim eht htiw derevoc erew sedils eht ,reffub noitazidirbyherp eht fo lavomer retfA rh rof C 73 ta detabucni dna edimamrof dezinoied %05 gniniatnoc reffub noitazidirbyherp ... 03 rof C 56 ta CSS × gniniatnoc reffub gnihsaw a ot derrefsnart ,CSS × dna CSS × ni eciwt dehsaw ,nim 01 rof C 73 ta )lm/gµ 05( A esaelcunobir htiw detaert neht erew snoitces eht ,nim...

Ngày tải lên: 07/08/2014, 18:21

... cytokines than the ContDCs, at 24, 48 h of incubation time (Fig 2) However, the taxol concentration used was critical for the level of cytokine production; μg/ml of taxol induced only marginal ... by that of the β-actin band, and the ratio at h was set at 100% (B) Fig NF-κB involvement in the taxol- induced effects on dendritic cells (DCs) The mobilization...

Ngày tải lên: 07/08/2014, 23:22

... INTRODUCTION Since the early 1960s the vegetation in a number of coastal areas has been affected by a kind of decline which, in terms of both quality and intensity, is very different from the ... trees of P pinea, P tobira, Q ilex and A opalus growing When interpreting the results of the chemical analysis of rainwater and deposits it is necessary to bear...

Ngày tải lên: 08/08/2014, 19:21

... the decision of continuing the ongoing therapy or stopping and redirecting the patient to other salvage therapies Our study also supports the idea of routine use of PET or preferably PET/CT in ... and serial imaging tests The subjects were divided into three groups 4/42 of the analysed scans were performed for preoperative staging (group 1), 30/42 of the for...

Ngày tải lên: 09/08/2014, 02:20

... interfere with the inflammatory response in SLE by administering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy Evidence for ... vascular permeability J Clin Invest 2002, 110:433-435 67 Aringer M, Graninger WB, Steiner G, Smolen JS: Safety and efficacy of tumor necrosis factor alpha blockade in systemic l...

Ngày tải lên: 09/08/2014, 10:22

... dimethyloxaloylglycine chondrocytes, and the effect of 2-methoxyestradiol (2ME2) on the expression of inflammatory cytokines (a) to (d) Administration of 2ME2 (10 μM) or of dimethyloxaloylglycine (DMOG) ... The data from the present work underline the requirement of adequate levels of HIF-1 for the viability of chondrocytes and for the maintenance of the integ...

Ngày tải lên: 09/08/2014, 13:22

... in the liver and some 18 in the pancreas Although there are high levels of HNF4A in the kidney only a few targets are known to be expressed in the kidney 1.6 HNF4A expression in the kidney Kidney ... knockout of HNF4A has not been carried out In our study we attempted to investigate the relatively unknown function of HNF4A in the kidney Involvement...

Ngày tải lên: 16/10/2015, 15:38