Role of hepatocyte nuclear factor 4a in the kidney

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... conﬁrmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên : 16/02/2014, 09:20

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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... rather than functional role Role of hydrophobic contacts in serine hydroxymethyltransferase In the present study, the importance of the third hydrop...

Ngày tải lên : 07/03/2014, 03:20

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

... of glycogen in the intact liver in vivo Second, during infusion of [1-1 3C ]glucose, label incorporation was observed not only into the C1 of glycogen but also the C6 , which can only occur by label ... a mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increas...

Ngày tải lên : 17/03/2014, 17:20

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Báo cáo khoa học: Hepatocyte nuclear factor-4a interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression pot

... Role of HNFs in transthyretin gene expression Z Wang and P A Burke Fig Mutation of the HNF binding site mainly disrupts the corresponding HNF binding ability, and not that of other HNFs Nuclear extracts ... treatment with cytokines HepG2 cells were treated with or without cytokines for 18 h The interaction of HNF protein with the DNA binding site was determined by ChIP assay...

Ngày tải lên : 23/03/2014, 03:20

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Báo cáo khoa học: Functional characterization of hepatocyte nuclear factor-4a dimerization interface mutants pot

... homodimer interface of HNF-4a contributing to the stability of the interface [11] The assignment of helices H3–H12 based on the crystal structure of HNF-4a, together with the point mutations of amino ... Ladias J (1997) Functional domains of the nuclear receptor hepatocyte nuclear factor J Biol Chem 272, 539–550 Hall RK, Scott DK, Noisin EL, Lucas PC & Granner DK (1992...

Ngày tải lên : 23/03/2014, 10:21

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Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx

... monophosphate kinases L Wang supply of nucleoside monophosphates may regulate the synthesis of nucleoside di- and triphosphates In Mollicutes, other enzymes exist that are capable of synthesizing nucleoside ... puriﬁcation of Ureaplasma nucleoside monophosphate kinases Primers used in PCR ampliﬁcation of Ureaplasma nucleoside monophosphate kinases...

Ngày tải lên : 30/03/2014, 08:20

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Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf

... responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin In addition, our data suggest that insulin stimulates cell division, in bovine thyroid cultures, ... signiﬁcant increase in concentration of the peroxidase inhibitor by the action of insulin, during 48 h, in thyroid primary cultures with 0....

Ngày tải lên : 30/03/2014, 14:20

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Báo cáo khoa học: " Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy" pptx

... noitazidirbyherp eht gniniatnoc erutxim eht htiw derevoc erew sedils eht ,reffub noitazidirbyherp eht fo lavomer retfA rh rof C 73 ta detabucni dna edimamrof dezinoied %05 gniniatnoc reffub noitazidirbyherp ... 03 rof C 56 ta CSS × gniniatnoc reffub gnihsaw a ot derrefsnart ,CSS × dna CSS × ni eciwt dehsaw ,nim 01 rof C 73 ta )lm/gµ 05( A esaelcunobir htiw detaert neht erew snoitces eht ,nim...

Ngày tải lên : 07/08/2014, 18:21

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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx

... cytokines than the ContDCs, at 24, 48 h of incubation time (Fig 2) However, the taxol concentration used was critical for the level of cytokine production; μg/ml of taxol induced only marginal ... by that of the β-actin band, and the ratio at h was set at 100% (B) Fig NF-κB involvement in the taxol- induced effects on dendritic cells (DCs) The mobilization...

Ngày tải lên : 07/08/2014, 23:22

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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt

... INTRODUCTION Since the early 1960s the vegetation in a number of coastal areas has been affected by a kind of decline which, in terms of both quality and intensity, is very different from the ... trees of P pinea, P tobira, Q ilex and A opalus growing When interpreting the results of the chemical analysis of rainwater and deposits it is necessary to bear...

Ngày tải lên : 08/08/2014, 19:21

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báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx

... the decision of continuing the ongoing therapy or stopping and redirecting the patient to other salvage therapies Our study also supports the idea of routine use of PET or preferably PET/CT in ... and serial imaging tests The subjects were divided into three groups 4/42 of the analysed scans were performed for preoperative staging (group 1), 30/42 of the for...

Ngày tải lên : 09/08/2014, 02:20

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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf

... interfere with the inflammatory response in SLE by administering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy Evidence for ... vascular permeability J Clin Invest 2002, 110:433-435 67 Aringer M, Graninger WB, Steiner G, Smolen JS: Safety and efficacy of tumor necrosis factor alpha blockade in systemic l...

Ngày tải lên : 09/08/2014, 10:22

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Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints" potx

... dimethyloxaloylglycine chondrocytes, and the effect of 2-methoxyestradiol (2ME2) on the expression of inflammatory cytokines (a) to (d) Administration of 2ME2 (10 μM) or of dimethyloxaloylglycine (DMOG) ... The data from the present work underline the requirement of adequate levels of HIF-1 for the viability of chondrocytes and for the maintenance of the integ...

Ngày tải lên : 09/08/2014, 13:22

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Role of hepatocyte nuclear factor 4a in the kidney

... in the liver and some 18 in the pancreas Although there are high levels of HNF4A in the kidney only a few targets are known to be expressed in the kidney 1.6 HNF4A expression in the kidney Kidney ... knockout of HNF4A has not been carried out In our study we attempted to investigate the relatively unknown function of HNF4A in the kidney Involvement...

Ngày tải lên : 16/10/2015, 15:38

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