Investigating the transcriptional regualtion of the stevor multi gene family in plasmodium falciparum

... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathwa...

Ngày tải lên: 25/10/2013, 21:20

... showing it to be the aldosterone synthase of the guinea pig It was interesting to note that CYP11B2 of the guinea pig had a considerably higher enzymatic activity in terms of 11b-hydroxylated ... 11bhydroxylase activity of CYP11B1 was strongly reduced (Fig 5), whereas that of the aldosterone synthase was basically unaffected, while the 18-hydroxla...

Ngày tải lên: 22/02/2014, 07:20

... by semiquantitative analysis of transcripts by Northern blotting and also by quantification of the enzyme protein by Western blotting Expression of Pf MDH, Pf LDH and Pf MQO in control and drug ... and purity of RNA the gels were stained with ethidium bromide and visualized on a UV transluminator Equal intensity of ribosomal RNA bands in all of the lanes ind...

Ngày tải lên: 16/03/2014, 18:20

... 3 1 1 1 1 )4 71, +467 )4 71 )4 71, )1 16 )3 96 )3 48 )3 48 )3 18, +109, +201 )2 67 )2 19, )1 38, +206 )1 53 )5 3 )5 2 )5 2 +222 +260 +423 +465 +466 a Numbers refer to the position of the 5¢-end of the conserved ... throughout the brain tissue in R6/1 compared to R6/2 mice [29,30] The differences between the two transgenic line...

Ngày tải lên: 16/03/2014, 18:20

... interaction between the main chain oxygen of Ala216 and the e-amine of Lys78 In H34A mutant (Fig 6B), the interaction between the imidazole ring and Asp214 disappeared and the side chain of Asp214 is ... conserved in HAP [8] placing Lys78 in a position that can compensate for the loss of His34 which allows for the interaction with the lytic hydroxyl in the a...

Ngày tải lên: 23/03/2014, 07:20

... pattern of expression of a gene [34–39] To evaluate the relevance of the leader intron in cardosin expression, we deleted it from the 5¢-flanking region of the genes (Fig 8) The deletion of the cardosin ... region of the cardosin B gene (from ) 147 bp to + 238 bp) .The 529 bp of the promoter region of the cardosin A gene that is relevant for gene...

Ngày tải lên: 30/03/2014, 09:20

... combinations of degenerate and specific primers and by rescreening the cDNA libraries The partial clones of XHIVEP2 and -3 covered 5.9 and 3.2 kb of the respective 3¢ ends and included 3¢-UTRs and poly(A)-tails ... analyze the function of XHIVEP in the context of Xenopus embryogenesis (data not shown) However, the interpretation of the in vivo role of...

Ngày tải lên: 30/03/2014, 13:20

... Cervidae, the same family as red deer and The PRNP gene in wild ruminants from Italy and Scotland 119 Fig The phylogenetic tree of similarity among the PRNP gene sequences of the analysed wild ruminants ... total of 323 red deer samples were collected from Scotland (n = 132; 82 from the mainland and 50 from the Isle of Rhum) and during th...

Ngày tải lên: 07/08/2014, 23:22

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 01:22

... Hypothetically, in RA synovial tissue the dominating Ang-1 induces the Tie2 pathway, whereas in normal synovial tissue higher Ang-2 presence blocks Ang-1 binding to Tie2 and inhibits its autophosphorylation ... al Tie receptors constitute a family of endothelial tyrosine kinase receptors [3,4] There are two members in this receptor family, termed Tie1 and Tie2...

Ngày tải lên: 09/08/2014, 03:24

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 13:22

... expression of duplicate GS genes in poplar To understand the regulation of the GS gene family in poplar and obtain further insight into the biological roles of members in the gene family, GS expression ... Principal Component Analysis (PCA) of GS genes and genes involved in lignin biosynthesis and C1 metabolism The expression profiles of GS genes were examined in silico durin...

Ngày tải lên: 11/08/2014, 11:21

... present in the tissues lacking TIP1;1 (Fig 2) It is therefore possible that these remaining isoforms compensate for the lack of TIP1;1 in the knockout On the other hand, the effect of the absence of ... expression of TIP3;1 and TIP1;1 in Arabidopsis and found minimal overlap in the timing of their expression, with TIP3;1 being abundant in embryos of matur...

Ngày tải lên: 12/08/2014, 03:21

... divided into five subfamilies; the plasma membrane intrinsic proteins (PIPs), the tonoplast intrinsic proteins (TIPs), the nodulin-26 like intrinsic proteins (NIPs), the small basic intrinsic proteins ... affecting the permeability of the pore since the orientation of the arginine of the ar/R filter is also stabilised by a hydrogen bond to the backbone of the C-l...

Ngày tải lên: 12/08/2014, 05:20

... There are several classes of drugs used for the treatment of malaria: 4aminoquinolines, arylaminoalcohols, 8-aminoquinolines, artemisinines, antifolates and inhibitors of the respiratory chain ... modifications in the protocol future experiments will allow the elucidation of the lengths of these 5‟UTRs Repeating these transfections and following the suggested modificat...

Ngày tải lên: 13/10/2015, 16:41