Understanding the mechanism of action of protein synthesis inhibitors against mycobacterium

... point of view, but also in that the total synthesis of each molecule reflects the limits of the power of the art and science of organic synthesis at the time of the accomplishment One of the most ... contributions to organic synthesis At the dawn of the twenty-first century, the state of the art and science of total synthesis is as hea...

Ngày tải lên: 29/04/2013, 10:27

... or texts, and that such data can be a source of knowledge yet they are assumed to be the experiential (tacit) and formal Understanding the Limitations of KMS (explicit) knowledge of actors This ... describes the case report and study findings; and, finally, Understanding the Limitations of KMS Section provides a discussion of the findings and offer...

Ngày tải lên: 20/12/2013, 19:15

... robust synthesis of pantothenate from low amounts of pantoate [9] Here, we report the results of the structural studies of the pantoate- bound form of the N-terminal domain of E coli PS (nPS) The structure ... [13] Details of the structural basis for the biochemically observed inhibition of plant PS by pantoate, as well as of the alleviation of...

Ngày tải lên: 16/02/2014, 09:20

... sensitivity of cells to inhibition of protein synthesis by TRAIL We have previously shown that protein synthesis is rapidly downregulated following exposure of cells to TRAIL and other inducers of apoptosis ... able to decrease the inhibition of protein synthesis by TRAIL by 80% (Fig 2A) and, conversely, IFNa enhanced the sensitivity of protein s...

Ngày tải lên: 19/02/2014, 06:20

... accumulation of propionyl-CoA (Fig 1) Addition of propionate to the glucose medium led to an increase of the propionyl-CoA level in the wild-type strain The methylcitrate synthase deletion strain showed ... formation of propionyl-CoA This observation readily explains the decreased propionyl-CoA levels found in cells grown on glucose/ acetate /propionate a...

Ngày tải lên: 19/02/2014, 16:20

... anchoring of a-carboxylate and a -amino group in the external aldimine defines automatically the positions of the a-proton and the side chain of any bound amino acid The lability of the a-proton ... from the amino group to the a-carbon atom of the quinonoid intermediate should go faster than the isotopic exchange of the proton in the active si...

Ngày tải lên: 19/02/2014, 16:20

... outside the cells, before internalization, we investigated the role of plasma membranes (PM) in the transformation of MSSAE into a dimeric protein 125I-labelled MSSAE was incubated with isolated ... reconstituted in the presence of growing broblasts into the parent dimeric protein, which is internalized as a native-like dimeric RNase They also indicate for the...

Ngày tải lên: 20/02/2014, 11:20

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inh...

Ngày tải lên: 22/02/2014, 04:20

... 6717 NF-jB regulates protein tyrosine kinase Tec L Yu et al to the regulatory region of the Tec promoter and induces expression of Tec A single NF-jB site is active in the mouse Tec promoter As there ... expression of the Tec tyrosine kinase NF-jB binds directly to the Tec promoter and induces Tec transcription The above results show that bo...

Ngày tải lên: 07/03/2014, 00:20

... between the nickel ion and the protein is the key feature of the binding process Further evidence that SlyD interacts with nickel ions with a : stoichiometry is provided by the analysis of the changes ... Structure and interactions of SlyD L Martino et al The constant of binding of the reaction Kb is dened as: Kb ẳ ẵPL ẵP ẵL 3ị The total concentrati...

Ngày tải lên: 30/03/2014, 01:20

... presence of the MinE deletion mutants 144 Cellular location of Gfp-MinD in the presence of increasing levels of MinE-M and MinE1-33-M 145 Localization of MinE deletion mutants in the presence of MinD ... With the aim of gaining a better understanding of the roles ATP and MinE play in the reversible association of the Min proteins with the membrane, we explo...

Ngày tải lên: 13/11/2014, 10:02

... conserved cytosolic quality control pathways remains to be discovered The objective of this thesis is to get a better understanding of protein quality control in cytosol and further understand the mechanism ... al., 1998) The binding induces several factors; one of them being ubiquitin expression indicating its role in the regulation of the degradation syst...

Ngày tải lên: 10/09/2015, 15:54

... the mechanism of action by Spry2 121 3.3.7 Increasing levels of PKD1 enhances the interaction between PKCδ and Spry2 122 3.3.8 Verification that PKD1 increases the interaction between Spry2 and ... 89 3.1.5 3.2 Characterizing the interaction between Spry2 and its interacting partners Discussion and Conclusions 89 Characterization of interaction betwe...

Ngày tải lên: 14/09/2015, 14:06

Ngày tải lên: 13/10/2015, 16:41

... of the polymerisation conditions with the template protein, where the challenge is to conserve the native structure of the template so as to imprint the ‘correct’ conformation of the target protein ... extended to the imprinting of macromolecules 2.3.2 Surface imprinting One of the major challenges faced in molecular imprinting, especially for the im...

Ngày tải lên: 08/11/2015, 16:46