Identification of plant as a novel and alternative host model for burkholderia pseudomallei

... Pseudomonas syringae and R solanacearum have been elucidated using Arabidopsis as a plant model (Quirino and Bent, 2003) 3.2 Materials and Methods 3.2.1 Plant Materials 3.2.1.1 Tomato and Arabidopsis ... and can be isolated from rice paddy fields in endemic areas such as Thailand Dharakul and Songsivilai first raised the question of a relationship between B pseudomallei and plants (Dharakul and ... Rice and Arabidopsis plantlets were also infected with B pseudomallei and B thailandensis to evaluate their potential as plant models for 48 disease Rice is chosen for evaluation as B pseudomallei...

Báo cáo y học: "Identification of kinectin as a novel Behçet''''s disease autoantigen" doc

... cells, and antibody to endothelial cell antigen (AECA) has been reported Reports on the prevalence of AECA have varied largely and alpha-enolase was reported as one of the putative target antigens ... kinectin by screening an aplastic anemia patient for candidate antigens using a Clontech human fetal liver cDNA expression library and it was concluded that seven out of 18 aplastic anemia patients ... analysis of the association of anti -kinectin antibody with different manifestations or disease 'subtypes' of BD is another important project Anti -kinectin is clearly only one of the antigen-antibody...

200 YEARS OF SAVINGS BANKS: A STRONG AND LASTING BUSINESS MODEL FOR RESPONSIBLE, REGIONAL RETAIL BANKING pot

... traditional commercial banks? Prof Giovanni Manghetti, Chairman, Cassa di Risparmio di Volterra 141 FOREWORD This is a report on the 200 Years of Savings Banks: A Strong and Lasting Business Model ... 200 YEARS OF SAVINGS BANKS: A STRONG AND LASTING BUSINESS MODEL FOR RESPONSIBLE, REGIONAL RETAIL BANKING The findings, interpretations and conclusions expressed in this paper not necessarily ... loans against personal guarantee were small, and therefore adapted to the category of customers that savings banks intended to serve Bigger loans against personal guarantee offered savings banks...

Báo cáo khoa học: Mammalian transglutaminases Identification of substrates as a key to physiological function and physiopathological relevance pot

... intracellular signalling and apoptosis, as well as in neurodegenerative and autoimmune diseases Consequently, its function may depend on its subcellular and cellular localization and on access to proteins ... Esposito and I Caputo 132 Akagi A, Tajima S, Ishibashi A, Matsubara Y, Takehana M, Kobayashi S & Yamaguchi, N (2002) Type XVI collagen is expressed in factor XIIIa+ monocyte-derived dermal dendrocytes ... Transglutaminasecatalyzed inactivation of glyceraldehydes 3-phosphate dehydrogenase and a- ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length Proc Natl Acad Sci USA 94,...

Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt

... experiments and participated in analysis of data CA performed the statistical analysis and the clinical associations AS participated in the analysis and interpretation of data and in the revision of the ... Capoano R, Profumo E, Siracusano A, Salvati B, Rigano R, et al.: Screening of a HUAEC cDNA library identifies actin as a candidate autoantigen associated with carotid atherosclerosis Clin Exp Immunol ... Isenberg DA, Ward FJ, Smith TA, Panayiotou A, Staines NA, Murphy JJ: Identification of candidate endothelial cell autoantigens in systemic lupus erythematosus using a molecular cloning strategy: a role...

Báo cáo y học: "Characterization of a novel and spontaneous mouse model of inflammatory arthritis" pptx

... A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K: A ... mice at early and late stages of disease Serum was isolated from AR and NAR littermates, and the levels of six cytokines were measured by cytometric bead array Only (A) IL-6 and (B) TNF -a were ... Comparative Pathology Laboratory at the University of California, Davis An animal necropsy was performed, and numerous organs and tissues were harvested for analysis Sections were examined and...

Báo cáo y học: "Characterization of a novel and spontaneous mouse model of inflammatory arthritis" doc

... 191:313-320 Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S: Altered thymic T-cell selection due to a mutation of the ZAP-70 ... concepts of rheumatoid arthritis Nature 2003, 423:356-361 doi:10.1186/ar3434 Cite this article as: Cuzzocrea S: Characterization of a novel and spontaneous mouse model of inflammatory arthritis Arthritis ... Poly-L-lysine-lysozyme CAIA GPI PLL-L DBA mouse Balb/c mouse DBA mouse Mouse CII antibody Mouse GPI antibody Cationic antigen New animal model Spontaneous Inherited inflamed joints strain IIJ Arthritic male mouse...

Identification of PARP1 as a transcriptional regulator of HBV replication

... Acetylation Inhibition Activation PARP1 Enzymes that result in PARP1 modification PP5 P PARP1 PARP2 ERK2 CaMK PARP3 PARG p300 SUMO3 Casp3 /CBP SUMO1 Casp7 R P PARP1 R R R Ac PARP1 PARP1 PARP1 Su PARP1 ... by activated PARP1, as PAR can be added onto PARP1 by other members of the PARP family such as the DNA repair enzyme PARP2 PARP1 can also exert its effects as an inactive enzyme For example, acetylation ... 35 Variable HBV Replication driving HBV pgRNA transcription, as well as a transfection efficiency marker to ascertain that undetectable HBV replication was not due to poor uptake of the plasmid...

Báo cáo y học: "A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy" pptx

... by an established experimental model regarding both viability and functionality of the cells Furthermore, specimens of breast cancer were also treated like the lung tumor samples to verify the ... druginduced expression of caspase-3 was analyzed by flow cytometry In a limited number of experiments, analyses of specific mRNA of caspase-3 were also performed by reverse transcriptase – polymerase ... (8/20 SCC) of all tested specimens, however, there were no related patterns of the drug-induced effects Discussion The major focus of this study was to examine the reliability of a novel ex vivo tissue...

A heat and mass transfer model for bread baking an investigation using numerical schemes

... 1971], Hayakawa et al [Hayakawa and Hwang, 1981], Zanoni [Zanoni and Peri, 1993] and many others The models proposed are based on individual assumptions and though they succeeded in modelling ... = ln πab a1 b1 +a + a2 + b2 √ a b b1 arctan √ + b a1 arctan √ a1 b1 (1.4) a arctan a − b arctan b where a= asp , L a= a1 = + a2 , bsp , L b1 = + b2 where, asp and bsp are the length and width ... physical changes during baking are already known, there are still processes remaining to be understood To study the physical changes during baking such as heat and mass transfer, a good mathematical...

Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics

... acidic proteins (Hathaway and Traugh, 1982) Two distinct casein kinases have been found in many different cell types They have been designated casein kinase (CK1) and casein kinase (CK2) according ... Ca2+/calmodulin-dependent protein kinase II cAMP cyclic adenosine monophosphate Cdk cyclin-dependent kinase Cdk5 cyclin-dependent kinase cDNA complementary deoxyribonucleic acid CK1 casein kinase CK2 casein kinase ... interacting proteins Using the former approach, the catalytic α subunit of protein kinase CK2 (formerly known as casein kinase 2) was isolated from rat brain extracts The direct associations of CK2 with...

Báo cáo y học: "Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behçet''''s disease" docx

... the protein Sip1 Sip1 is a nuclear splicing factor containing an arginine/serine-rich domain and a RNAbinding motif that may play a role in linking the processes of transcription and pre-mRNA ... participated in the design and revision of the study and performed the statistical analysis RP participated in the design and revision of the study AS participated in the analysis and interpretation ... of data and helped to draft the manuscript RR participated in the design of the study and in the revision of the manuscript EP participated in analysis of data GV participated in the design of...

Báo cáo y học: "Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis" ppt

... UCSC annotated sequences (UCSC Refflat file) and finally to non-coding RNA classes (fRNAdb, database of ncRNA.org): piwi-interacting RNA (piRNA), tRNA, rRNA, small nucleolar RNA (snoRNA) and other ... pre-miR-30d, RNA was extracted and analyzed at day of differentiation Mature miRNA expression was evaluated using Mirscript assays (Qiagen SA) as specified by the manufacturer’s protocol Real-time ... et al.: Small RNA sequencing reveals miR64 2a- 3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis Genome Biology 2011 12:R64 Submit your next manuscript...

Identification and functional validation of caldesmon as a potential gastric cancer metastasis associated protein

... Distant metastasis Presence of distant metastasis cannot be assessed No distant metastasis Distant metastasis Table 1.1 TNM staging classification of gastric cancer 11 1.2.2 Metastasis Is a Multi-Step ... Hou Q, Tan HT, Lim KH, Lim TK, Khoo A, Tan IB, Yeoh KG, Chung MC Identification and Functional Validation of Caldesmon as a Potential Gastric Cancer Metastasis- associated Protein vii Table of Contents ... IDENTIFICATION AND FUNCTIONAL VALIDATION OF CALDESMON AS A POTENTIAL GASTRIC CANCER METASTASIS- ASSOCIATED PROTEIN HOU QIAN B Sc (Hons.), NTU A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF...

DEVELOPMENT OF e SRS (ENVIRONMENT SENSING RESPONSE SYSTEM) AS a NOVEL METHOD TO DISTINGUISH GENETIC ENVIRONMENTS AND RESOLVE CLOSELY RELATED NUCLEIC ACID SEQUENCES

... chimera genes Our novel adaptation of the Mz separated the activating segment of the RNA from the cleaved segment, such that the activating RNA and cleaved RNA became separate RNA species (i .e. , ... clearance of malaria parasites [Mens et al, 2007], poor sensitivities at low but clinically relevant levels of parasitaemia, and the false negatives of certain strains that epitope diversity may lead ... Non-targeted Sequence Typically an RNA sequence that is close to the NTS, and needs to be distinguished from the NTS by e- SRS Nucleic acid Target Sequence An nucleic acid sequence that is to be targeted...

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