Gene expression profiling in a rat model of neurodegeneration

... effects, after intraperitoneal injection of KA in rats (Wilson et al 2005) and increased expression of genes related to neurodegeneration and astrogliosis after intraperitoneal KA-nicotine injection ... Model of Neurodegeneration _ CHAPTER GENE EXPRESSION ANALYSIS OF HIPPOCAMPUS IN KAINATE RAT MODEL OF NEURODEGENERATION 23 Chapter Gene Expression of Hipp...

Ngày tải lên: 07/10/2015, 09:55

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... TGF-β1 in the urine of male rats after CYP were also significantly higher than the levels of active and total TGF-β1 in the urine of female rats, both at baseline and after CYP (ANOVA, Tukey post ... control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine of CYP-treated female rats remained higher as compared to both CY...

Ngày tải lên: 11/08/2014, 08:22

... (5’-GGCGUGUCUCUCU UACGAC-3”) SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1 ), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2 ), 5’-GAGCCGGAAAGUUAUUGUG-3’ ... tissues was significantly lower in the CCI group during the course of 255 TLR4 -siRNA treatment, indicating that intrathecal administration of TLR4 -siRNA significantl...

Ngày tải lên: 25/10/2012, 11:48

... with an intra-peritoneal injection of 400 mg/kg chloral hydrate (Pharmaceutical Plant of Tiantan Hospital, Beijing, China) The rectal temperature was monitored and maintained at 37.5°C A scalp incision ... infarcted brain parenchyma of transplanted rats (A- iii and A- iv) A comparable extent of class II MHC was noted in ischemic rats irrespective of any therapy but unrema...

Ngày tải lên: 18/06/2014, 16:20

... and in vivo [11] Interestingly, microglial cell activation by chronic infusion of lipopolysaccharide (LPS) appears to be capable of inducing a selective degeneration of nigral dopamine (DA) neurons ... panel) and 21 (bottom tracersdays measured6-OHDA lesion of dopamine terminal loss and inflammaA) Using A) Using micro-PET and selective radioactive tracers we measured i...

Ngày tải lên: 19/06/2014, 22:20

... Justicia C, Camins A, Planas AM: Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia Brain Res Mol Brain Res 1999, 65:61-69 Zhang W, Potrovita I, Tarabin V, Herrmann ... without craniectomy in rats Stroke 1989, 20:84-91 Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK: N-Acetyl cysteine protects against injury in a rat mod...

Ngày tải lên: 19/06/2014, 22:20

... were obtained from a rat brain atlas by Paxinos and Watson The injection was made at a rate of μl/ using a 10 μl Hamilton syringe with a 26-gauge needle At the end of each injection, the syringe ... Contralateral rotation measurements following administration of apomorphine in each experimental group are shown in bar graph at days and 21 days post-6-OHDA injection Data...

Ngày tải lên: 19/06/2014, 22:20

... receptor antagonist effectively reduced the mast cell activatorinduced visceral allodynia [8] In addition, it was also reported that experimental activation of proteinase-activated Role of mucosal mast ... Princeton Instrument, USA) Three sections per animal were examined and the number of MMC was counted in at least 10 randomly selected fields using an image analyzing softw...

Ngày tải lên: 07/08/2014, 18:20

... changes in rats after unilateral 6OHDA lesioning and dopaminergic neuron grafting Some of the dynamic and static parameters were altered in rats with 6-OHDA-induced lesions including paw contact ... Wageningen, The Netherlands) before 6-OHDAlesioning or sham operation The rats that had received 6OHDA were evaluated again weeks after 6-OHDA injection and at weeks after tr...

Ngày tải lên: 10/08/2014, 05:21

... surfactant preparations via the trachea has no impact on the amount of the intracellular surfactant pool [39], recent data suggest that alterations of the intracellular surfactant can occur already ... that the alterations of intracellular surfactant were significantly associated with early postoperative oxygenation and total intubation time [26] The intrace...

Ngày tải lên: 12/08/2014, 13:22

... Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism Kyle D Allen1,2, Mohammed F Shamji1,3, Brian A Mata2, ... during the early phase of lumbar radiculopathy may distinguish a focal unilateral pathology of lumbar radiculopathy from the generalized pain s...

Ngày tải lên: 12/08/2014, 17:22

... Critical Care February 2005 Vol No Van Putte et al high mortality rate for the patient Some causes of warm ischemia–reperfusion injury are cardiopulmonary bypass during cardiac surgery and pulmonary ... 30 to hours of reperfusion in a model of acute lung injury, which was defined by quantifying apoptosis and alveolar oedema R2 Materials and methods Animals Male inbred...

Ngày tải lên: 12/08/2014, 20:20

... permeability and leads to the formation of brain edema in septic rats Magnesium administration attenuated the increased BBB permeability and caused a reduction in brain edema formation in our rat ... D, Kalaycý R, Cakar N, Kaya M, Telci L: Effects of magnesium administration on brain edema and blood brain barrier breakdown after experimental traumatic brain injury...

Ngày tải lên: 12/08/2014, 20:20

... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expr...

Ngày tải lên: 14/08/2014, 08:20