Exploration of the functional significance of mig 2 in human cancer cell susceptibility to cytotoxic agents and cell growth control a pilot study

... all their signaling effects by recruiting and activating different intracellular signaling and adaptor proteins ECM binding initiates clustering of integrins in the plane of the membrane and ... Briefly, a pilot study was initiated to explore the functional significance of an uncharacterized gene mig- 2 in human cancer cells, focusing on cell suscep...

Ngày tải lên: 05/10/2015, 22:15

... primary blasts Haematologica 2008, 93:662-669 34 Sharma SV, Haber DA, Settleman J: Cell < /b> line-based platforms to < /b> evaluate the < /b> therapeutic efficacy of < /b> candidate anticancer agents Nat Rev Cancer < /b> ... Gautschi O, Mack PC, Davies AM, Lara PN, Gandara DR: Aurora < /b> kinase inhibitors: a < /b> new class of < /b> targeted drugs in < /b> cancer < /b> Clin Lung...

Ngày tải lên: 18/06/2014, 22:20

... inhibitors Conveniently, it is < /b> standard clinical practice to < /b> perform karyotyping on hematological < /b> cancer < /b> cells and chromosome < /b> number < /b> can serve as a < /b> resistance marker for patient response < /b> to < /b> GSK1070916 ... percentage of < /b> polyploidy in < /b> cell < /b> subpopulations For instance, the < /b> karyotype data for the < /b> T...

Ngày tải lên: 20/06/2014, 04:20

... al.: Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis Arthritis Research & Therapy 2011 13:R62 Submit your ... Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases Cytokine Growth Factor Rev 2006, 17:295-304 Shao WH, Zhe...

Ngày tải lên: 12/08/2014, 15:23

... prostaglandins (PGs) play important roles in inflammatory process of respiratory system [7] PGs are synthesized from arachidonic acid by a reaction catalyzed by cyclooxygenase Two isoforms of this enzyme ... constitutively in almost all tissues [9], and COX-2 is an inducible enzyme that is expressed in response to inflammatory cytokines [10] Increased expression of COX-2 has bee...

Ngày tải lên: 12/08/2014, 18:21

... of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism ... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast c...

Ngày tải lên: 12/10/2015, 17:36

... (Klinka et al, 1991).The park has a mean annual precipitation of 258 mm and a mean annual temperature of 9.8°C Soils are typically coarse textured (loamy sand to sandy loam, with a clay content of ... Fe, Al and Si Oxalate Fe and Al were extracted using acid ammonium oxalate extraction, and dithionite Fe, Al and Si were extracted using citrate-bicarbonatedithionate extra...

Ngày tải lên: 08/08/2014, 19:21

... article as: Mueller et al.: Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®®) in human cancer cell lines Journal of Experimental & Clinical Cancer Research 2011 30:42 Submit ... varying from 0.3 mg/ml to 0.54 mg/ml yielding in a RAA of 1.7-3.3 (Figure 1) Detection of the mode of cell death induced by FWGE in a panel of c...

Ngày tải lên: 10/08/2014, 10:21

... dalteparin in ICU patients with subcutaneous oedema with anti-Xa activity in ICU patients without subcutaneous oedema Materials and methods This non-randomized open parallel group follow-up pilot ... anti-Xa activity measured for the two groups are given in Table and Figure Peak anti-Xa activity (Cmax) is the anti-Xa activity three hours after admini...

Ngày tải lên: 12/08/2014, 23:24

... element binding protein J Virol 1995, 69:5806-5811 Kimzey AL, Dynan WS: Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking ... Petropoulos L, Lin R, Hiscott J: Human T-cell leukemia virus type Tax protein increases NF-κB dimer formation and antagonizes the inhibitory activity of the IκBα reg...

Ngày tải lên: 13/08/2014, 13:20

... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 281 Table Bcl-2 immunoreactivity in cell phenotypes of the spinal cords of normal and EAE rats ... Tae-Kyun Shin Fig Immunostaining for Bcl-2 (A, B) in EAE Intense Bcl-2 immunoreactivity is found in neurons and glial cells in...

Ngày tải lên: 07/08/2014, 15:20

... bone fracture healing J Bone Miner Res 2002, 17:963-976 Einhorn TA Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 2002, 17:977-978 Zhang X, Schwarz EM, Young DA, Puzas ... activity of a glucocorticoid-regulated inflammatory cyclooxygenase Proc Natl Acad Sci USA 1992, 89:4888-4892 Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflammatory the...

Ngày tải lên: 09/08/2014, 01:21

... 11, 13 and TIMP-1 and TIMP-2 and their distribution in tissue is shown in table The expression in all the cases of MMP-1 thus neoplastic, fibroblasts and endothelial cells, may indicate a link action ... action in the degradation of the stroma The expression of MMP-2 was present basically in the neoplastic cells In the case of MMP-9 most of the...

Ngày tải lên: 09/08/2014, 07:22

... types of human cancer However, the mechanism of COX-2 in angiogenesis remains unclear In this study, the data showed that down-regulation of COX-2 could significantly inhibit the in vitro and in ... et al.: The function and mechanism of COX-2 in angiogenesis of gastric cancer cells Journal of Experimental & Clinical Cancer Research 201...

Ngày tải lên: 10/08/2014, 10:21

... scanned and digital images of proteins were analyzed Calpain activity Calpain activity was measured as described by Tompa et al [26] Cells were washed with and scraped in ml of icecold PBS, and ... activation in a therapeutically useful manner In any case, the results here indicate that COX-2 is degraded by calpain, and that PIN1 regulates its expression via e...

Ngày tải lên: 11/08/2014, 08:22