Exploration of the functional significance of mig 2 in human cancer cell susceptibility to cytotoxic agents and cell growth control a pilot study

... al.: Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis Arthritis Research & Therapy 2011 13:R62 Submit your ... Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases Cytokine Growth Factor Rev 2006, 17:295-304 Shao WH, Zhen Y, Eisenberg RA, Cohen PL: The Mer receptor tyrosine ... partly, due to a shift of cytokine production in the phagocytes from pro-inflammatory cytokines to cytokines that are anti-inflammatory [23,32] Mer is also required for development of B- [33] and...

... prostaglandins (PGs) play important roles in inflammatory process of respiratory system [7] PGs are synthesized from arachidonic acid by a reaction catalyzed by cyclooxygenase Two isoforms of this enzyme ... constitutively in almost all tissues [9], and COX-2 is an inducible enzyme that is expressed in response to inflammatory cytokines [10] Increased expression of COX-2 has been reported in human pulmonary epithelial ... Atorvastatin also affects COX-2 expression in human pulmonary epithelial cells Because of importance of COX-2 in inflammatory respiratory diseases, we tested the effects of Atorvastatin on lipopolysaccharide...

... of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism ... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines ... highest in terms of mortality rate (WHO, 2008), while according to the Singapore Cancer Registry, in 17 women will develop breast cancer in her lifetime in Singapore The risk of getting breast cancer...

... (Klinka et al, 1991).The park has a mean annual precipitation of 258 mm and a mean annual temperature of 9.8°C Soils are typically coarse textured (loamy sand to sandy loam, with a clay content of ... Fe, Al and Si Oxalate Fe and Al were extracted using acid ammonium oxalate extraction, and dithionite Fe, Al and Si were extracted using citrate-bicarbonatedithionate extraction, with extracted ... vegetation and humus form and accounts for much of the variation in the chemical properties of the surface mineral soil CONCLUSION wood to have affected Decaying appeared properties of the forest...

... article as: Mueller et al.: Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®®) in human cancer cell lines Journal of Experimental & Clinical Cancer Research 2011 30:42 Submit ... varying from 0.3 mg/ml to 0.54 mg/ml yielding in a RAA of 1.7-3.3 (Figure 1) Detection of the mode of cell death induced by FWGE in a panel of cell lines In order to distinguish the mode of cell ... Oxaliplatin and Irinotecan in human colon cancer cell lines The combined drug effect of a parallel exposure to FWGE and either 5-FU, irinotecan or oxaliplatin was assessed in a panel of colon cancer cell...

... dalteparin in ICU patients with subcutaneous oedema with anti-Xa activity in ICU patients without subcutaneous oedema Materials and methods This non-randomized open parallel group follow-up pilot ... anti-Xa activity measured for the two groups are given in Table and Figure Peak anti-Xa activity (Cmax) is the anti-Xa activity three hours after administration of dalteparin Page of (page number ... citation purposes) The pharmacokinetics of dalteparin is linear and dose-independent for anti-Xa activity Absorption is rate-limiting after subcutaneous administration and peak plasma concentrations...

... element binding protein J Virol 1995, 69:5806-5811 Kimzey AL, Dynan WS: Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking ... Petropoulos L, Lin R, Hiscott J: Human T-cell leukemia virus type Tax protein increases NF-κB dimer formation and antagonizes the inhibitory activity of the IκBα regulatory protein Virology 1996, 225:52-64 ... Bex F, Yin MJ, Burny A, Gaynor RB: Differential transcriptional activation by human T-cell leukemia virus type Tax mutants is mediated by distinct interactions with CREB binding protein and p300...

... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 281 Table Bcl-2 immunoreactivity in cell phenotypes of the spinal cords of normal and EAE rats ... Tae-Kyun Shin Fig Immunostaining for Bcl-2 (A, B) in EAE Intense Bcl-2 immunoreactivity is found in neurons and glial cells in the spinal cords of normal rats (A) In EAE, intense Bcl-2 immunoreactivity ... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 283 10 11 12 13 14 15 Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte...

... bone fracture healing J Bone Miner Res 2002, 17:963-976 Einhorn TA Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 2002, 17:977-978 Zhang X, Schwarz EM, Young DA, Puzas ... activity of a glucocorticoid-regulated inflammatory cyclooxygenase Proc Natl Acad Sci USA 1992, 89:4888-4892 Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflammatory therapy Am J ... selectivity of this group of compounds might allow inflammation to be inhibited with minimal effects on certain homeostatic mechanisms, their role in bone metabolism and repair remains unclear Review of...

... 11, 13 and TIMP-1 and TIMP-2 and their distribution in tissue is shown in table The expression in all the cases of MMP-1 thus neoplastic, fibroblasts and endothelial cells, may indicate a link action ... action in the degradation of the stroma The expression of MMP-2 was present basically in the neoplastic cells In the case of MMP-9 most of the cases were negative both tumoral and reactive cells The ... cellular components of the vascular wall On the other hand, 12 cases of the present series showed a more intense expression of TIMP-1 in epithelial cells, mainly the mucosal gland, whose structures...

... types of human cancer However, the mechanism of COX-2 in angiogenesis remains unclear In this study, the data showed that down-regulation of COX-2 could significantly inhibit the in vitro and in ... et al.: The function and mechanism of COX-2 in angiogenesis of gastric cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:13 Acknowledgement This study was supported in part ... proliferation of SGC7901 cells (Figure 2A) As shown in Figure 2B, down-regulation of COX-2 might inhibit the malignant growth of SGC7901 cells in vivo Down-regulation of COX-2 inhibited angiogenesis of gastric...

... scanned and digital images of proteins were analyzed Calpain activity Calpain activity was measured as described by Tompa et al [26] Cells were washed with and scraped in ml of icecold PBS, and ... activation in a therapeutically useful manner In any case, the results here indicate that COX-2 is degraded by calpain, and that PIN1 regulates its expression via effects on calpain activity in MAEC ... partial reduction of calpain activity may be due to the incomplete (85%) suppression of PIN1 by the shRNA [6] PIN1 may also function as a modulator of calpain activity and not as an absolute requirement...