Dual activation of estrogen receptor a and aryl hydrocarbon

Dual activation of estrogen receptor a and aryl hydrocarbon receptor by the prenylflavone, icaritin restrict breast cancer cell growth and destabilize estrogen receptor a protein

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that p...

Ngày tải lên : 04/10/2015, 17:05

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Báo cáo khoa học: "Ectomycorrhization of Acacia holosericea A. Cunn. ex G. Don by Pisolithus spp. in Senegal: Effect on plant growth and on the root-knot nematode Meloidogyne javanica Robin Duponnois" potx

... density on the number of nematodes per plant and the leaf mineral concentrations Mycorrhizal treatments Number of nematodes inoculated Number of nematodes per plant Mineral concentrations (% of dry ... Ectomycorrhization of Acacia holosericea in Senegal 25 °C in the dark in order to achieve a good coverage of the paper card The filter paper covering th...

Ngày tải lên : 08/08/2014, 14:22

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Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx

... designated HeLaTR /4-1BB and HeaLaTR/ TRAF1, respectively Primers for amplifying the 4-1BB and TRAF1 cDNAs were: 5¢-GAATTCAAGCTTATGGGA AACAGCTGTTACAACATA-3¢ and 5¢-GAATTCAAG CTTCACAGTTCACATCCTCCTTCTTCT-3¢ ... used for amplifying the hTRa1 cDNA were: 5¢-CCCGGGAAGCTTCGGACCATGG AACAGAAGCCAAGCAAGGTG-3¢ and 5¢-CCCGGG GTCGACGACTTCCTGATCCTCAAAGACCTC-3¢ In order to overexpress 4-1BB...

Ngày tải lên : 23/03/2014, 18:20

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Báo cáo khoa học: A (1ﬁ3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of ﬁbrinogen-like protein and epidermal growth factor gene expression pot

... from the Diptera Anopheles gambiae (ENSAN1_ANGA, XP_312118.1), (ENSAN5_ANGA, XP_312116.1) and (BACBP_ANGA, CAA04496.1), as well as the GLUBP from the lobster Homarus gammarus (GLUBP_HOGAM, CAE47485.1) ... curdlan Then, extracts were prepared and subjected to PAGE in the presence of a low concentration of SDS and in the absence of b-mercaptoethanol After size separa...

Ngày tải lên : 16/03/2014, 16:20

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Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples pptx

... 5¢-UCAUCGCAUUCC UUGCAAAdTdT-3¢, antisense strand 5¢- UUUGCAAGGAAUGCGAUGAdTdT-3¢; ERa siRNA #3 sense strand 5¢- GGAGAAUGUUGAAACA CAAdTdT-3¢, antisense strand 5¢- UUGUGUUUCAA CAUUCUCCdTdT-3¢ The transfection ... that miR-22 is frequently downregulated in ERa-positive human breast cancer cell lines and clinical samples In addition, further functional studies showed that E...

Ngày tải lên : 22/03/2014, 21:20

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Báo cáo y học: "Discovery of estrogen receptor α target genes and response elements in breast tumor cells" ppsx

... activity and expression profiles of target genes A number of genes, including those for trefoil factor 1/ pS2, cathepsin D, cyclin D1, c-Myc and progesterone receptor, are positively regulated by ... factor binding elements occur very frequently in the genome, finding an ERE, AP-1 or Sp1 site only in ER-responsive genes is highly unlikely Instead, we asked whether the pr...

Ngày tải lên : 14/08/2014, 14:21

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Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN -REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... signaling 21 1.3.4 Regulation of estrogen receptors 23 1. 3.5 Estrogen and estrogen receptors in human breast cancer 27 v 1. 4 THE SODIUM HYDROGEN EXC...

Ngày tải lên : 10/09/2015, 15:49

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Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts ppt

... enriched in hydrophobic residues In yeast, proteins targeted to mitochondria Fig Overview of dual targeting of proteins to mitochondria and chloroplasts in plant cells A gene encoding a dual- targeted ... Thus, dual targeting does not appear to be a strategy of limiting gene number in Dual targeting of proteins the nuclear genome As outlined pr...

Ngày tải lên : 07/03/2014, 03:20

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Báo cáo khoa học: Stimulation of ﬁbroblast proliferation by neokyotorphin requires Ca2+ inﬂux and activation of PKA, CaMK II and MAPK/ERK pdf

... should induce activation of all protein kinases shown to contribute to the neokyotorphin effect Both PKA and CaMK II are known to be activated by Ca2+ inﬂux, in the case of CaMK II activation is ... established as neokyotorphin- effect mediators in L929 cells, are PKA, CaMK II and MAPK Discussion Fig Effect of lM neokyotorphin and 50 lM 8-Br-cAMP in L92...

Ngày tải lên : 07/03/2014, 11:20

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Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc

... Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the transcription factors NF -jB1 (p50) and ... Table Inhibition of proliferation of LXF-289 lung tumor cells Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A)...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx

... regulated by cytosolic Ca2 + by means of CaM Among the channels with a- subunits of the 6-TM family similar to hEAG1, Ca2 +activated K+ channels of the IK ⁄ SK type [7,8,10], nonselective cation channels ... threshold (Fig 2) and by assuming that a CaM binding domain has to have a length of at least around 15 residues For quantitative estimates of...

Ngày tải lên : 07/03/2014, 12:20

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Coffee consumption modifies risk of estrogen- receptor negative breast cancer pdf

... between coffee consumption and breast cancer risks for ER-positive and ER -negative breast cancers In this study, we examine the association between coffee consumption and postmenopausal breast cancer ... http:/ /breast- cancer- research.com/content/13/3/R49 Page of 10 Table Associations of coffee consumption and breast cancer risk factors in Swedish study (c...

Ngày tải lên : 22/03/2014, 17:20

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An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology potx

... production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients Eur J Cancer 1997, 33(4):602-607 Nalbandian G, Kovats S: Understanding ... calcitonin, and environmental factors like dietary calcium intake and physical activity In addition to these factors, estrogen and serotonin play an important role in t...

Ngày tải lên : 28/03/2014, 14:20

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aging of the genome the dual role of dna in life and death mar 2007

... consistent theories of how we age First formulated in the 1950s, the somatic mutation theory explains aging as a gradual accumulation of random alterations in the DNA of the genome in the cells of our ... to function The causes of aging: a random affair 12 17 23 The logic of aging 27 2.1 2.2 2.3 2.4 2.5 28 36 39 47 52 Aging genes Pleiotropy in agi...

Ngày tải lên : 11/06/2014, 10:21

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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc

... MEK -ERK1/2 pathway played dual roles in cumulus cells One role is the induction of EGF-like factor and TACE /ADAM17 expression The other is direct induction of cumulus expansion of porcine COCs In ... expression of EGF-like factor and TACE /ADAM17 in cumulus cells was induced by a PKA-, p38 MAPK- and ERK1/2- dependent mechanism du...

Ngày tải lên : 20/06/2014, 07:20

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