Crystallization trials of refolded breast tumor kinase (BRK) and peroxisome proteins

... of Brk, an important kinase involved in lymphoma and then initiated crystallization of the refolded protein In the second part, in collaboration with Prof Suresh Subramani’s Lab (University of ... overexpressed GST-Pex8 and GST-Pex20 (two important peroxins in Pichia pastoris) and initiated their crystallization 2.1 BREAST TUMOR KINASE (BRK) 2.1.1 Protein tyrosin...

Ngày tải lên: 04/10/2015, 10:24

... dispersion 10 Model building and refinement 11 1. 5.2 .1 R Factor 11 Validation and presentation 11 1. 5.3 .1 Ramachandran Plot 12 1. 5.3.2 Folding profile methods 12 CHAPTER BIOLOGY BACKGROUND 2 .1 2.2 BREAST ... COLLECTION 1. 5 STRUCTURE DETERMINATION iv    1. 5 .1 Phasing techniques 1. 5.2 1. 5.3 1. 5 .1. 1 Direct method 1. 5 .1. 2 Molecular replacement 1. 5 .1. 3...

Ngày tải lên: 16/10/2015, 15:36

... by CKI modulates its ability to interact with synaptotagmin Phosphorylation of syntaxin-1A by CKII increases its ability to interact with synaptotagmin [21] In addition, the phosphorylation of ... Fig Phosphorylation of centaurin-a1, 14-3-3, syntaxin-1A, and munc18 by CKI, CKII and PKA Casein kinase I a (CKIa, upper panel), casein kinase II (CKII, middle p...

Ngày tải lên: 22/02/2014, 04:20

... (carcinoids and related endocrine variants) of the breast: an analysis of 310 reported cases Int Surg 2001, 86:26-32 Hartgrink HH, Lagaay MB, Spaander PJ, Mulder H, Breslau PJ: A series of carcinoid ... regarding either adjuvant chemotherapy or somatostatin analogues in primary breast carcinoid tumors To date there is no standardized treatment regarding carcinoid tumors o...

Ngày tải lên: 09/08/2014, 01:24

... involved an ACC intermingled with a subtype of a ductal carcinoma (papillary) Another patient with ACC mixed with an “ordinary” invasive ductal and intra -ductal carcinoma was reported by Righi et al ... doi:10.1186/1752-1947-5-437 Cite this article as: Kontos et al.: Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a cas...

Ngày tải lên: 10/08/2014, 23:20

... of their study groups could identify their group registration Discussion The primary objective of this review was to characterize the types of control procedures used in controlled clinical trials ... Back Pain - A Systematic Review Pain Res Manage 2011 doi:10.1186/2045-709X-19-3 Cite this article as: Vernon et al.: Systematic review of clinical trials of ce...

Ngày tải lên: 13/08/2014, 15:21

... http://www.translational-medicine.com/content/7/1/75 Figure Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic Pathways Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic ... serine-threonine kinases, lipid kinases, adhesion molecules and other diffusible signaling proteins The abundance of multiple PTKs and other kinase...

Ngày tải lên: 18/06/2014, 15:20

... nipple-sparing mastectomy The superior or inferior periareolar with lateral extension, transareolar with perinipple and lateral-medial extension, transareolar and transnipple incision with medial and ... subclavicular areas of the breast for tumor removal All incisions have equal risk of necrosis but women under 45 years of age had a higher rate of NAC viability [21]...

Ngày tải lên: 09/08/2014, 01:24

... uncommon and account for less than 0.2% of all primary breast lesions, without a striking difference of incidence between male and female as for ductal epithelial cancers [1] The majority of cases ... cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favour of a unifying histog...

Ngày tải lên: 09/08/2014, 07:21

... al.: Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-a Journal of Experimental & Clinical Cancer Research 2011 30:22 Figure 10 Effects of UTI and ... in breast cancer and the effects of ulinastatin on its expression level Chin J Biol 2009, 22:548-551 10 Gong Y, Sun X, Huo L: Expression of...

Ngày tải lên: 10/08/2014, 10:21

... Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian ... Prognostic significance of Ki-67 and topoisomerase II expression in infiltrating ductal carcinoma of the breast a multivariate analysis of 863 cases Breast C...

Ngày tải lên: 10/08/2014, 22:20

... Nair SG, Hamati HF: Primary small cell anaplastic carcinoma of the breast, diagnosis by fine needle aspiration cytology: a case report Acta Cytol 1998, 42:1199-1203 Yamasaki T, Shimazaki H, Aida ... argyrophil variant of lobular carcinoma of the breast Lobular carcinoma is always negative for Caderin E, whereas SCNC is positive in 100% of cases as in this situation...

Ngày tải lên: 11/08/2014, 12:20

... flat epithelial atypia and lobular neoplasia, tubular carcinoma and low-grade intraductal carcinoma [5-7] Retrospective analyses have suggested that they may represent a marker of a slightly increased ... continuum between MLT and mucinous carcinomas [3] The spectrum of breast alterations characterized by variably enlarged terminal-ductal lobular units lined by variably hype...

Ngày tải lên: 11/08/2014, 23:21

... cells Having validated the inhibitory potential of AZT in a single-round infection experiment, we sought to determine whether AZT can also inhibit spread of the virus in cultures of infected human ... Identification of a subdomain in the Moloney murine leukemia virus envelope protein involved in receptor binding J Virol 1996, 70:1768-1774 Davey RA, Zuo Y, Cunningham J...

Ngày tải lên: 13/08/2014, 05:22

... set of miRNA expression profiles for primary human breast cancer we selected 99 primary human tumors, normal breast samples and 33 breast cancer cell lines for miRNA expression profiling Tumor ... studies of miRNA expression in human breast cancer have focused on comparing normal tissues to tumor samples Here we focused on miRNA expression analysis of a...

Ngày tải lên: 14/08/2014, 08:20