Clinical reference of tumour infiltrating lymphocytes in colorectal cancer

... REFERENCES 67 iv SUMMARY Background: Approximately 10-30% of colorectal cancers are characterized with distinctly high densities of tumour- infiltrating lymphocytes (TILS), including ... affect the clinical phenotype of tumours Indeed, one of the most reproducible findings in prognostic studies has been that a high density of tumourinfiltrating lymphocytes (TILS) is ass...

Ngày tải lên: 03/10/2015, 20:57

... melanoma Cancer Lett 2009, 285:80-88 doi:10.1186/1479-5876-9-63 Cite this article as: Zuliani et al.: Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable ... Pandolfino MC, Tessier MH, Bercegeay S, Cassidanius A, Lemarre P, Billaudel S, Labarriere N, Jotereau F: Randomized trial of adoptive transfer of melanoma...

Ngày tải lên: 18/06/2014, 19:20

... melanoma Cancer Lett 2009, 285:80-88 doi:10.1186/1479-5876-9-63 Cite this article as: Zuliani et al.: Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable ... Pandolfino MC, Tessier MH, Bercegeay S, Cassidanius A, Lemarre P, Billaudel S, Labarriere N, Jotereau F: Randomized trial of adoptive transfer of melanoma...

Ngày tải lên: 20/06/2014, 03:20

... Cite this article as: Rao et al.: Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review ... metastasis disease without evidence of remaining macroscopic disease) Clinical outcomes to evaluate ASI in suspected minimal residual CRC were...

Ngày tải lên: 18/06/2014, 19:20

... the healing of tissue, reintroducing a high concentration of platelets directly into the injured area should theoretically enhance the healing process The physiological effects include: Increase ... to overuse injuries resulting in micro tears of the tissue These types of injuries are difficult to heal and are a risk for re-injury A recent study published in the American Journal...

Ngày tải lên: 23/10/2013, 21:15

... particular phase of the cell cycle, and was associated with an increase in the sub-G1 (apoptotic) portion of the cell cycle We next investigated the effect of combining CDO with the chemotherapeutic ... possible model of drug interaction in GEO cells, which involves the complex interaction of proteins involved in cell cycle regulation To recapitulate, com...

Ngày tải lên: 07/03/2014, 15:20

... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell ... a potent inhibitor of mitogen-activated protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacody...

Ngày tải lên: 16/03/2014, 00:20

... aAPCs-based expansion TILs K562 cells expressing CD64, CD137L and CD28 ligands CD80 and CD86, pulsed with anti-CD3 antibody efficiently activate and expand CD8+ CD28- T cells and antigen- specific T cells ... CD28 on T cells, enabling efficient polyclonal expansion of circulating T cells (50 to 1000-fold) over 10-14 days of ex vivo culture with preferential expans...

Ngày tải lên: 18/06/2014, 22:20

... records included signalment, clinical signs on admission and historical findings, physical examination findings, results of biochemical analyses, information on concurrent diseases, and outcome In ... diseases, and outcome In the case of hypoadrenocorticism, a combination of clinical signs, clinical chemistry profiles, and the value of an adrenocorticotropin (ACTH) stimu- la...

Ngày tải lên: 07/08/2014, 14:23

... anti-HBc in publicly-funded patients in a major county medical center outpatient setting The dynamic changes in ALT and their correlation with development of clinical evidence of cirrhosis was also ... interferon related therapies in chronic HCV patients Ying-Cho Lin, MS, is a Research Biostatistician, Medical Genetics Institute, Cedars-Sinai Medical Center...

Ngày tải lên: 08/08/2014, 18:20

... (11.9%), in ascending colon of 14 patients (15.2%), in transverse colon of subjects (8.7%), in hepatic flexure of patients (8.7%), in splenic flexure of patients (7.6%), in descending colon of 10 ... resection and type of operation are important prognostic factors In a recent Table 2: Results of multivariate analysis of clinical and laboratory data...

Ngày tải lên: 09/08/2014, 07:21

... IL-12 and IL-23, in human and mouse myeloid cells, respectively [11,12] In summary, this paper raises intriguing questions about the diverse roles played by TNFα in adjuvant-induced arthritis ... production of anti-nuclear antibodies and accelerated onset of disease [8] TNFα was also shown to have anti-inflammatory properties depending on the timing of TNFα expression in a mur...

Ngày tải lên: 09/08/2014, 10:23