CHARACTERISATION OF DRUG INDUCED CELL DEATH IN MYCOBACTERIUM SMEGMATIS

... TABLE OF CONTENTS ABSTRACT v LIST OF TABLES vi LIST OF FIGURES vii INTRODUCTION 1.1 CELLULAR ENVIRONMENT INDUCED DEATH 1.2 ANTIBIOTIC INDUCED CELL DEATH 1.3 THE COMMON DEATH PATHWAY- GOING AGAINST ... a in e d IN H h IN H h 5 1 0 5 0 0 * IC M IC IN IN H IN H IN H H /2 M M IC IC M IC l /5 IN H IN C H o n M tr o IC M IC IN IN H H M M IC IC M /2 IN IN H H C...

Ngày tải lên: 02/10/2015, 17:15

... Role of JNK in radiation- induced mitochondrial cell death M.-J Kim et al Fig Ionizing radiation induces expression of Fas and activation of caspases in human cervical cancer cells (A) Ionizing radiation- induced ... development of molecular targets for cancer treatment Results To examine the kinetics of the apoptotic cell death induced by ionizi...

Ngày tải lên: 07/03/2014, 05:20

... actually induces lipid peroxidation Mitochondrial lipid oxidation is involved in cell death kinetics Fig Respiration-induced cis-parinaric acid oxidation in isolated mitochondria Mitochondria ... Mitochondrial ROS production also appears to be involved in yeast ageing [59] Bax-induced lipid oxidation The present study evidences an additional oxidant function for...

Ngày tải lên: 23/03/2014, 21:20

... neuronal death FEBS J Teixeiro E & Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation ... ERK- mediated cell death: sustained and sequestered activity ROS as mediators of ERK- induced cell death In the majority of the studies rela...

Ngày tải lên: 29/03/2014, 08:20

... resulting in intracellular ionic imbalance and activation of the inflammasome (Ichinohe et al 2010) Although influenza infection results in activation of the inflammasome in both lung stromal and ... ciliated epithelium results in initial shrinkage and vacuolaization of the cells, culminating in necrosis and eventual desquamation of these cells into the luminal space The...

Ngày tải lên: 10/09/2015, 15:53

... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell ... a potent inhibitor of mitogen-activated protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacody...

Ngày tải lên: 16/03/2014, 00:20

... 269) investigate the mechanism behind the DENSPM -induced cell death in the L56Br-C1 cells with the further aim of identifying the markers for an apoptotic response to polyamine depletion The L56Br-C1 ... analysis The cells were sonicated in 50 mM Tris/HCl (pH 7.5) containing 0.25 M sucrose The activity of SSAT in the sonicate was determined by measuring...

Ngày tải lên: 17/03/2014, 23:20

... transfection (Fig 6E) 10 1 FL2-H 10 2 10 3 10 1 LQ: 3% 10 0 10 1 FL2-H 10 2 10 3 UQ: 97% LQ: 97% 10 0 10 2 10 3 FL1-H 10 4 10 1 D 10 0 Fig Analysis of ANT1 -silencing on DW dissipation and the effect of the mitochondrial ... ANT1 -silencing According to this hypothesis, we found that ANT1 siRNA-treated cells 10 2 FL1-H 10 3 10 4 10 3 10 4 UQ: 86% 10 3 10 4 L...

Ngày tải lên: 29/03/2014, 09:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cel...

Ngày tải lên: 18/06/2014, 19:20

... important role in the secondary activation of microglia, in the progression of the inflammatory response, and in the progressive loss of the dopaminergic neurons in MPTPinduced PD Therefore, COX-2 ... oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% of the remaining of the init...

Ngày tải lên: 19/06/2014, 22:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In...

Ngày tải lên: 20/06/2014, 03:20

... analyzed whether treatment with the Akt-inhibitor ErPC3 would increase the short- time antineoplastic effects of ionizing radiation in the prostate cancer cell lines Combined treatment with ErPC3 and ... reduced the number of viable LNCaP, PC3 and DU145 cells as determined by the WST-1 test In PC3 and DU145 cells the antineoplastic effects of th...

Ngày tải lên: 09/08/2014, 09:20

... QD induced cell death involving Fas, lipid peroxidation and mitochondrial impairment Proposed mechanism of QD induced cell death involving Fas, lipid peroxidation and mitochondrial impairment Cells ... QD-treated cells, again reinforcing the protective role of free NAC against QD-induced toxicity Upregulation of Fas at the cell surface and internalization of QDs...

Ngày tải lên: 11/08/2014, 00:22

... little emphasis in the past The objective was to determine the mode of lymphocyte cell death upon exposure to the gaseous phase of cigarette smoke (GPS) in vitro For this purpose, we utilised a well-established ... significantly different (p < 0.62) FACS analysis of Annexin V/PI-stained cells To determine the mode of cell death upon GPS treatment,...

Ngày tải lên: 12/08/2014, 14:20

... factor (TNF)-induced shock in certain situations and actually exacerbate liver injury [9] In addition to apoptosis, certain caspases, such as caspase-1, are involved in cytokine maturation by ... immunosuppression in prolonged sepsis in at least two major fashions: the elimination of key effector cells and, alternatively, the capacity of apoptotic cells to induce anergy and...

Ngày tải lên: 13/08/2014, 18:22