Targeting polo like kinase 1 in glioma propagating cells

Targeting polo like kinase 1 in glioma propagating cells

... of glioma 1. 4 Re-defining assay criteria for detecting GPCs 10 1. 5 PLK1 regulation and physiological role 11 1. 5 .1 PLK1 regulation 11 1. 5.2 Physiological role of PLK1 13 1. 5.3 PLK1 and tumors 15 ... 1. 9 34 3.3 PLK1 mRNA expression is elevated in glioma tumors PLK1 over-expression is common in several cancers of the breast 116 , ovaries 117 , prostate 118 and skin...

Ngày tải lên : 02/10/2015, 17:13

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Báo cáo y học: "RNA interference against polo-like kinase-1 in advanced non-small cell lung cancers" doc

... strand, while the silencing activity of the siRNA was maintained [18] Polo-like kinase-1 (PLK-1) belongs to the family of serine/threonine kinases and regulates cell division in the mitotic phase ... the systemic siRNA delivery with atelocollagen existed intact for at least days in tumor tissues using a mouse model [62] Preclinical application of RNAi therapy against PLK-1 in a...

Ngày tải lên : 10/08/2014, 09:22

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Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target

... (Polo- like kinase of X laevis); Snk (serum-inducible kinase) ; Fnk (fibroblastgrowth-factor-indiucible kinase) ; Prk (proliferation-related kinase) ; Sak (Snk akin kinase) xvi Table II: Polo- like kinase ... hours after transfection Caspase-3 activity assay was carried out (Fig 8) and intrigued to find that caspase-3 activation in si-PLK1 transfected Huh-7 was absent in th...

Ngày tải lên : 16/10/2015, 15:38

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Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps

... removal of cellular debris by phagocytes Transient appearance of low affinity anti-single-stranded or dsDNA antibodies, preferentially of IgM and < /b> IgG3 isotypes, will probably accompany any systemic ... secondary to cellular activation [116] Interestingly, medications that can cause drug-induced lupus (e.g hydralazine and < /b> procainamide) are capable of blocking methyltransferase ac...

Ngày tải lên : 09/08/2014, 07:20

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Investigation of the roles of two rac1 effectors phosphatidylinositol 5 kinase 1a and p21 activated kinase 1 in insulin secreting cells

... INVESTIGATION OF THE ROLES OF TWO RAC1 EFFECTORS PHOSPHATIDYLINOSITOL- 5 KINASE Iα AND P 21- ACTIVATED KINASE IN INSULINSECRETING CELLS ZHANG JIPING (B.Sc., SICHUAN University) A THESIS SUBMITTED ... PIP5K-Iα in insulin secretion in INS -1 cells 11 1 4 .1. 3 Implication of PIP5K-Iα in PIP2 production in INS -1 cells 1 15 4 .1. 4 Role of...

Ngày tải lên : 14/09/2015, 14:08

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Báo cáo hóa học: " Herpes Simplex Virus Type 1 Us3 Gene Deletion Influences Toll-like Receptor Responses in Cultured Monocytic Cells" pdf

... simplex virus turns off TAP to evade host immunity Nature 19 95, 375: 411 - 415 Page 10 of 11 (page number not for citation purposes) Virology Journal 2008, 5 :14 0 10 11 12 13 14 15 16 17 18 19 20 21 22 ... moi HSV -1 (KOS) moi 10 d120 moi HSV -1 (F) moi HSV -1 (F) moi R7306 moi R7306 moi R70 41 moi R70 41 moi HSV -1 (KOS) moi d120 moi d120 moi uninfected 10 10 0 d...

Ngày tải lên : 20/06/2014, 01:20

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Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps

... GS: Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen -activated protein kinase kinase kinases in rheumatoid arthritis J Immunol 2004, 17 2 :16 12 -16 18 Huang Q, Yang J, Lin Y, Walker C, Cheng ... purposes) Arthritis Research & Therapy 10 11 12 13 14 15 16 17 18 19 20 21 Vol No Hammaker et al Mor A, Abramson SB, Pillinger MH: The fibroblast-like syno...

Ngày tải lên : 09/08/2014, 10:20

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IMPAIRED CARDIOVASCULAR RESPONSES TO GLUCAGON-LIKE PEPTIDE 1 IN METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITUS

... monoclonal antibodies against cardiac troponin I (ab1 02 31; 1: 1,000), 4’,6diamidino -2- phenylindole (DAPI; 10 0 ng/ml), and rabbit polyclonal antibodies raised against GLP-1R (ab390 72; 1: 25 ) for one hour ... areas of investigation, impaired regulation of coronary vascular function and reduced cardiac glucose metabolism are believed to be important factors (11 , 13 , 14 ,...

Ngày tải lên : 24/08/2014, 12:16

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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf

... al.: Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors Journal ... in cerebral vasculature by anandamide provides a new mechanism that may explain the therapeutic action of increased anandamide tone in...

Ngày tải lên : 19/06/2014, 22:20

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Báo cáo y học: "Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis" ppsx

... freshly isolated PB and ST CD4+ T cells from RA patients STAT3 is activated by a variety of cytokines, notably the IL-6 family of cytokines (e.g IL-6, IL 11, leukemia inhibitory factor, and oncostatin ... was incubated with the antibodies (rabbit IgG) anti-STAT1 antibody, antiphosphorylated tyrosine 7 01 of STAT1 antibody, antiSTAT3 antibody, and anti-phosphorylated t...

Ngày tải lên : 09/08/2014, 01:24

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Báo cáo y học: "Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells." pot

... Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells Daniel Z Mackesy1 and Marc L Goalstone1,2,* Department of ... pathogenesis of atherosclerosis by augmenting the effects of inflammatory cytokines, thereby significantly increasing the expression of CAMs [6-11] One such cyto...

Ngày tải lên : 11/08/2014, 03:20

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Báo cáo y học: "A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis" pps

... crucial role for tumor necrosis factor receptor in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis Arthritis Research & Therapy 2 010 , 12 :R 61 ... = 0. 01 Ct, cycle threshold; IL, interleukin; TNF, tumor necrosis factor Page of 11 Figure Tumor necrosis factor receptor (TNFR1) silencing in t...

Ngày tải lên : 12/08/2014, 12:20

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Báo cáo y học: " Microarray identifies ADAM family members as key responders to TGF-β1 in alveolar epithelial cells" ppsx

... confirm the microarray- identified alterations in ADAM family members in alveolar epithelial cells in response to TGF-β1 mRNA levels of ADAM Family members are altered in response to endogenous ... important in driving the local fibrotic milieu in the lung The ADAM gene family encompasses the ADAM (A disintegrin and metalloproteinase domain containing...

Ngày tải lên : 12/08/2014, 16:20

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ROLES OF HUNTINGTIN ASSOCIATED PROTEIN 1 IN INSULIN SECRETING CELLS

... INTRODUCTION 1. 1 β-cell and insulin secretion 1. 1 .1 Diabetes mellitus 1. 1.2 Insulin 1. 1.3 Insulin secretion 1. 1.4 insulinsecreting cell model 1. 1.5 β-cell growth and cell cycle 1. 2 HAP1 10 1. 2 .1 HAP1 background ... of HAP1 in insulinsecreting cells after knockdown of its expression in INS -1 cell line The findings of HAP1 role in INS -1 cel...

Ngày tải lên : 12/10/2015, 17:35

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