FUNCTIONAL CHARACTERISATION OF ASAP1 IN HCC PROGRESSION AND METASTASIS

... membrane and associate with proteins such as focal adhesion kinase (FAK), vinculin, paxillin, integrin-linked kinase and talin on the cytoplasmic side Integrins also link bundles of actin filaments ... motility and invasiveness in vitro and stimulation of metastasis formation in vivo To the best of our knowledge, this study is novel in investigating the role and mechan...

Ngày tải lên: 01/10/2015, 17:28

... Barash et al New concepts for heparanase function B A Fig (A) Immunohistochemical staining of heparanase in squamous cell carcinoma of the head and neck (SCCHN) tumor specimens Formalin-fixed, paraffin-embedded ... multifaceted protein engaged in multiple aspects of tumor progression, combining enzymatic activity-dependent and -independent activities of heparanase an...

Ngày tải lên: 15/03/2014, 23:20

... study we have investigated the role of CCR7 in the recruitment of CD4+ memory T cells into the inflamed joints of patients with JIA, and attempted the functional and anatomical dissection of these ... degree of disease activity and treatment at the moment of sampling Expression of CCL21 in SF and synovial tissue To gain further insight into t...

Ngày tải lên: 09/08/2014, 06:22

... muscles of the helicine arteries are relaxed, blood inflow to the lacunar spaces increases Relaxation of the smooth muscle of the trabeculae then dilates the lacunae, allowing for the expansion of the ... tissue against the tunica albuginea which in the process, compresses the subtunical venules against the tunica (the stretching of the tunica also compres...

Ngày tải lên: 12/10/2015, 17:33

... expressing gp120/gp41 to proteoliposomes containing CD4 and CCR5 A: Binding of the 35 S-labelled soluble version of gp120/gp41, strain JR-FL to CD 4CCR5 or only CCR5 containing proteoliposomes containing ... polylinker region of the pcDNA3.1myc-His expression vector (Invitrogen, Groningen, the Netherlands) in order to obtain a recombinant protein containing the C-myc...

Ngày tải lên: 08/03/2014, 09:20

... [52,53] Pharmacological targeting of matrix metalloproteinases On the basis of the pivotal roles that MMPs and ADAMs play in several steps of cancer progression, the pharmaceutical industry has invested ... threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development of carcinogenesis...

Ngày tải lên: 15/03/2014, 00:20

... University Results Immunostaining Trip10 is differentially methylated in human cancer cell lines and primary tumor specimens Cells were fixed in 2% formaldehyde in phosphate buffered saline (PBS) and ... Overexpression of Trip10 in IMR-32 cells caused Trip10 and huntingtin to colocalize and form perinuclear foci In contrast, while overexpression of Trip10 in...

Ngày tải lên: 10/08/2014, 05:21

... and binds phosphatidic acid (PA) via a TAPAS domain in its unique N-terminal region An increase in intracellular CA2+ brings about binding of PDE4A1 to PA and insertion into lipid bilayers in an ... domain REC domains play a crucial role in bacterial signalling systems They may also be involved in protein-protein interactions (Galperin 2010) Phosphorylation of the REC domain may...

Ngày tải lên: 22/12/2014, 21:15

... features of Fronting in English and Khởi ngữ in Vietnamese? (2) What are the similarities and differences in the structure and function of Fronting in English and Khởi ngữ in Vietnamese? Scope of ... and structures of fronting in English and khởi ngữ in Vietnamese 2.3 Data collection 50 sentences in English containing the fronti...

Ngày tải lên: 28/02/2015, 11:54

... Statistical analysis 50 Chapter Results 51 3.1 Expression and functional analysis of HS3ST3B1 in 51 prostate cancer 3.1.1 Expression of HS3ST3B1 in prostate cell lines 51 and tissues 3.2 Functional analysis ... analysis of HS3ST3B1 in 77 prostate cancer 3.4.1 Clinicopathological parameters of prostate 77 cancer patients in study 3.4.2...

Ngày tải lên: 05/10/2015, 22:31

... bilateral ovarian mature teratoma, using both biochemical and histological techniques The Patient Clinical Findings An eight- year- old female presented with a three-week history of abdominal swelling ... high amounts of mucin- like amino acids, serine, threonine and proline Serine and threonine are points of O-glycosylation found in the tandem repeat regions of mucin...

Ngày tải lên: 26/10/2012, 10:03

... rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon therapy Treatment of advanced ... receiving combination therapy Hepatology 2004;40:1450-8 15 Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR A pilot study of the tolerability and efficacy of...

Ngày tải lên: 31/10/2012, 17:11

... program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social ... vital in fighting poverty The adult education program can thus harness the local languages and indigenous knowledge of the minority and...

Ngày tải lên: 05/11/2012, 16:27

... the risk of U.S .- Soviet confrontation, and simultaneously placed some constraints on the behavior of superpower allies • In spite of constraining factors, the first decade and a half of the U.S .- Soviet ... from brandishing its nuclear forces in peripheral conflicts The distinctive nature of the Cold War shaped the evolution of U.S nuclear strategy and...

Ngày tải lên: 17/02/2014, 11:20

Ngày tải lên: 18/02/2014, 11:20