... competition of proBMP-2 with BMP-2 for binding to the main receptor BMPR -IA, BIAcore experiments were performed For these studies, the ECD of the receptor was recombinantly produced in Escherichia coli ... with mature BMP-2 for binding to BMP receptor IA (BMPR -IA) , one of the main receptors of mature BMP-2 [6,27,28] In contrast, the ECD of BMPR-II was not bound by proBMP-2 Furthermore, the free propeptide ... result shows that the pro-peptide moiety does not interfere with binding of the mature part to BMPR -IA As the BMPR -IA binding site for BMP-2 partially overlaps with the area bound by the antagonist...