Mechanisms of GTP depletion induced apoptosis in HIT t15 insulin secreting cells

... THE APOPTOSIS INDUCED BY GTP- DEPLETION IN INSULIN- SECRETING CELLS 57 3.2.1 Induction of apoptosis by GTP depletion with MPA treatment 57 3.2.2 Activation of caspases and release of cytochrome ... transglutaminase in GTP depletion- induced apoptosis of insulin- secreting (HITT15) cells Biochemical Pharmacology 66, 213-223 Jianxin Huo, Stewart A Metz...

Ngày tải lên: 17/09/2015, 17:18

... subsequent inflammation [30-32] To gain insight into the mechanism of arsenic trioxide (ATO)-induced apoptosis, we examined the modulation of phosphatidylserine externalization in HL-60 promyelocytic leukemia ... megakaryocytic leukemia [47] Our result is in support of previous findings indicating that ATO induces clinical remission in a high proportion of patients with...

Ngày tải lên: 10/08/2014, 22:21

... of apoptosis [26] We therefore examined the involvement of caspases in the apoptosis induced by Py/Zn PARP is a substrate of caspases, and proteolysis of PARP is an index of activation of caspases ... activation of caspases in Py/ Zn-induced apoptosis Activation of p38MAPK was determined by Western blot analysis using an antibody for the activated form of...

Ngày tải lên: 23/03/2014, 21:20

... plasma membrane integrity It Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells 25 Fig Flowcytometric detection of apoptosis of A549 cells treated ... rate of 10-14% in the USA [11] Therefore, it is clear that Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A...

Ngày tải lên: 07/08/2014, 23:22

... capindependent protein translation was responsible for early apoptosis To understand the relative roles of cap-dependent and -independent protein translations in NNK-induced apoptosis in human bronchial ... transfection with bicistronic constructs To determine the status of cap-dependent and independent protein translation in NNK-induced apoptosis in human b...

Ngày tải lên: 07/08/2014, 18:20

... molecules in the course of hypoxia-induced apoptotic pathways Such analysis of trophoblastic cells will, in the near future, yield insights into the mechanisms of preeclampsia and other hypoxia-related ... and by modulating phosphorylation of JNK In conclusion, various pro- and antiapoptosis-related proteins were expressed in the process of hypoxia-induced apoptos...

Ngày tải lên: 31/10/2012, 15:12

... Hsp105 enhances oxidative stress-induced apoptosis (Eur J Biochem 269) 4149 Fig Suppression of oxidative stress-induced apoptosis in F9 cells by a potent p38 inhibitor F9, V1, S3 and S23 cells were ... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells usin...

Ngày tải lên: 21/02/2014, 03:20

... lovastatin in rat brain neuroblasts undergoing apoptosis may be mediated by caspase-7 Because caspase inhibition could block lovastatininduced cleavage of focal adhesion proteins and PKCd, we investigated ... Actin levels remained constant (Fig 2C) Effect of lovastatin on the cleavage of PKCd C Fig Effect of lovastatin on FAK and p130Cas proteins in imm...

Ngày tải lên: 23/03/2014, 11:20

... downregulation of caIII gene expression mediated by Evi1 Results Evi1- expressing Rat1 fibroblasts are resistant to taxol-induced apoptosis Independent, stable populations of Rat1 cells expressing murine Evi1 ... expression increases sensitivity to H2O2-mediated apoptosis in complete contrast to the protective effect of other apoptosisinducing agents Increased...

Ngày tải lên: 29/03/2014, 08:20

... this article as: Bordón et al.: Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs) Radiation Oncology ... Hernandez LA, Lara PC, Pinar B, Fontes F, Rodriguez Gallego C, Lloret M: Prediction of clinical toxicity in localized cervical carcinoma by r...

Ngày tải lên: 09/08/2014, 10:20

... recently GIS and remote sensing has been using in several types of works in both government and private agencies As we know, GIS and remote sensing have an important role in linkage and analysis of ... data, in particular for detection, interpretation, area calculation, monitoring and future estimating Therefore, this study applied GIS and remote...

Ngày tải lên: 17/03/2014, 11:20

... the intrinsic kinase activity of DAP kinase is critical for apoptosis The mechanism of DAP kinase activation has not been clear DAP kinase undergoes phosphorylation and the intrinsic activity is ... ®ndings clearly demonstrate that DAP kinase activity is critical for C2- and C8-ceramideinduced apoptosis in PC12 cells DISCUSSION DAP kinase i...

Ngày tải lên: 24/03/2014, 00:21

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... article as: Johnson et al., CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion Journal of Ovarian ... resistance to chemotherapy by means of inactivating apoptotic factors and enhancing survival pathways that antagonize apoptosis signals [2] However,...

Ngày tải lên: 20/06/2014, 07:20

... light-induced photorelaxation, in a concentration dependent manner Mechanism of UV light-induced photorelaxation in isolated rat aorta 83 Fig Effects of UV light irradiation on vascular relaxation of rat ... determine which isoform acts as messenger in UV light-induced photorelaxation, Ca2+-free and Ca2+channel blocker, verapamil were introduced in rat a...

Ngày tải lên: 07/08/2014, 14:23