Studies on the anti cancer potential of sesquiterpene lactone parthenolide
Studies on the anti cancer potential of sesquiterpene lactone parthenolide 1
... Abbreviations xv List of Publications xix CHAPTER INTRODUCTION 1. 1 Parthenolide 1. 1 .1 Introduction: feverfew and Parthenolide 1. 1.2 Chemical structure, metabolism and bioactivities of parthenolide 1. 1.2 .1 ... balance 1. 2 .1 Reactive Oxygen Species 17 1. 2 .1. 1 Definition 17 1. 2 .1. 2 Sources of ROS 18 1. 2.2 Biothiols 19 1. 2.2 .1 Definition 19 1. 2.2.2 Biological properties and metabolism 20 1. 2.3 Anti- oxidant ... Limitations in current study and further directions 18 0 6.5 18 8 6 .1 Conclusions 17 1 17 5 18 4 18 7 CHAPTER REFERENCES ix SUMMARY Parthenolide is the major sesquiterpene lactone responsible for the bioactivities...
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Studies on the anti cancer potential of sesquiterpene lactone parthenolide
... focused on the anti- inflammatory activity of parthenolide On the other hand, the anti- cancer potential of parthenolide has rarely been studied Thus, the main objective of this study is to further ... investigate the anti- cancer potential of parthenolide by studying its sensitization effects on cancer cells in response to death receptor ligands To further validate the anti- cancer property of parthenolide ... al., 2004) However, the anti- cancer potential of parthenolide is still largely unknown Further studies, including both in vitro mechanism studies on anti- cancer potential of parthenolide and in...
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Studies of the anti cancer potential of flavonoids in human nasopharyngeal carcinoma cells
... C: Insulin and LiCl prevent down-regulation of cyclin D1 induced by luteolin in HK1 cells Fig 3.7D: Insulin and LiCl abrogate the effects of luteolin on CNE2 cells Fig 4.1: Combined effect of ... during the cell cycle where synthesis of both cyclins B1 and B2 is initiated during the interphase and localised in the cytoplasm During the prophase, cyclin B1 migrates from the cytoplasm to the ... indirectly by p16INK4A as the latter binds and inhibits cdk4/6-cyclin D and thus maintains the tumour suppressor activity of pRb through the inhibition of E2F The loss of p16INK4A will inhibit Rb activity,...
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STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE: Vol. 1: General Concepts and Case Studies pptx
... Studies on the Ecology and Conservation of Butterflies in Europe STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE Vol 1: General Concepts and Case Studies Edited ... Nowicki, Studies on the Ecology and Conservation of in Europe Sofia – Moscow Vol 1: General Concepts and Case Studies, p 38 Altitudinal life-history variation and temperature adaptations in copper butterflies ... Proceedings The first volume General Concepts and Case Studies encompasses the Ecology of Butterflies (3 sections) and the Conservation of Butterflies and Global Change” (two sections), while the...
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A study on the anti tumor activity of LY303511, an inactive analogue of a p13k inhibitor, LY294002
... activated caspase resulting in release of cytochrome c from the mitochondria and subsequent activation of caspase and amplification of the caspase activation cascade downstream of the mitochondria ... sufficient activation of caspase to induce a direct amplification of the caspase activation cascade that involve downstream caspases like caspase 3, caspase and caspase Cells that utilize primarily the ... human cancer than any other pathway, with the exception of the p53 and retinoblastoma pathways, thus underlining its importance as a therapeutic target for anti cancer strategies (Hennessy et al.,...
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Comparative studies on the infection and colonization of maize leaves by fusarium graminearum, f proliferatum and f verticillioides
... (Sacc.)Nirenberg,isolateAG11iwereutilizedforexaminingtheeffectsofthedifferent factorsontheinfectionofFusariumintomaizeleaves .F. graminearumwasincludedin theexperimentoneffectofinoculationsitesofFusariuminfectionandmanifestationof symptomsonmaizeplants.Theseisolateswereobtainedfromtheculturecollectionof ... and cultivar on the infection of Fusariumspeciesintomaizeleaves. ii examinetheeffectsofinoculumdensityoninfectionofmaizeleaves. iii evaluatetheeffectsoflightonFusariuminfectionofmaizeleaves. 2.2.Materialsandmethods ... B=atBBCH3335.(Meier,1997) 14 FactorsaffectinginfectionofFusarium 2.2.3.2.Impactofsporeconcentrationontheinfectionofmaizeleaves To assess the impact of spore concentration on Fusarium infection of different maize...
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Báo cáo y học: "tatin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis" pptx
... demonstrated that the regulation of CD59 by statins in hypoxia was inhibited by mevalonate and geranylgeraniol, confirming a role for inhibition of HMG-CoA reductase and geranylgeranylation, respectively ... anti-inflammatory action of statins in RA The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal attack complex has the potential to exert antiinflammatory ... that cycles of hypoxia and reoxygenation within the synovium may also exacerbate complement activation In situ analysis has demonstrated abundant local synthesis of C3, C3aR, C5aR and C5b-9 at...
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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression of cell cycle controlling ... with genistein 10 μM and irradiation with Gy together, the effects of genistein on survival in these cell lines seem to be independent of ER- and p53-expression In contrast, low concentrations of ... after incubation with genistein concentrations of 15 – 30 μM in FCS-containing media [41] In this study the NF-κB activity was investigated, too An inhibition of radiationinduced activation of NF-κB...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... 6A,B) In the present study, we compared the functional roles of the N- and C-terminal regions of 4482 H Tanaka et al molluskan and vertebrate TnI and revealed for the first time that (a) the alternative ... of the troponin complex In molluskan muscles, the C-terminal region does not function and troponin regulates contraction only through the activation exerted by the N-terminal region of TnI Experimental ... amount of nonspecific precipitation of the TnI-fragment was also monitored by simultaneous centrifugation of the sample containing no actin-tropomyosin under the same conditions Reconstitution of...
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Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
... group of Glu207 into phytoene (the main labeled component of the lipidsoluble fraction) is systematically diminished by the addition of increasing amounts of [1-3H ]2C-methyl-D -erythritol 4-phosphate ... Formation of 4-(cytidine 50 -diphospho)-2-C-methyl-D -erythritol from 2-C-methyl-D -erythritol 4-phosphate by 2-C-methyl-D -erythritol 4-phosphate cytidyltransferase, a new enzyme in the nonmevalonate ... H (2000) Studies on the nonmevalonate pathway: formation of 2-C-methyl-D -erythritol 2,4-cyclodiphosphate from 2-phospho4-(cytidine 50 -diphospho)-2-C-methyl-D -erythritol Tetrahedron Lett 41,...
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Case Studies on the Effectiveness of State Financial Incentives for Renewable Energy pdf
... regions of the state On the other hand, only a small fraction of those claiming the tax credit take advantage of the low-interest loan Furthermore, the property-tax exemption complements the ... National Laboratory, Matthew Brown of the National Conference of State Legislatures, Jane Weissman of the Interstate Renewable Energy Council, Frederick Beck of the Renewable Energy Policy Project, ... given the purpose and scope of this project—and the variety of factors influencing decisions toward the purchase of renewable energy systems—we use the term effectiveness in the context of the...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R1–YFP – genetic variant of dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein (D1 CFP and D2R2–YFP ... two dopamine D2 receptor fusion proteins (D2 CFP and D2 YFP) f Measured in cell co-expressing two dopamine D2 receptor fusion proteins (D2 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) ... of dopamine D2 receptor) e Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) f Measured in cell co-expressing dopamine...
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Báo cáo khoa học: Biosynthesis of isoprenoids – studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase pdf
... above, these initial conditions were rapidly conducive to steady conditions where and were present in very similar concentrations, and the rates of the forward reaction (conversion of to 3) and the ... Discussion The main part of the present study was a search, under conditions of maximal stringency, for fragment exchange that could be the hallmark of the hypothetical retroaldol–aldol mechanism The ... 4-phosphate [28] The reductive reaction step has been shown to involve the transfer of a hydride ion from the pro-S position at C-4 of NADPH to the RE position of C-1 of reaction intermediate...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the ... better stability than the other form (Fig 4C) The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein Similarly, the Cm of the holo form always...
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Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... of phosphorylation rate seen at the concentration x of H4biopterin vo is the rate in the absence of H4biopterin and vmin is the rate at very high concentrations of H4biopterin The observed Hill ... H4biopterin, the oxidized cofactor H2biopterin and the catecholamine inhibitor dopamine From Fig 3A it is seen that on preincubation with saturating concentrations (Fig 3B) of the biopterin cofactors ... binding changes the position and orientation (relative to the catalytic iron) and the hydrogenbonding network of the bound H4biopterin Moreover, the substrate induced repositioning of the cofactor also...
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Từ khóa: ten empirical studies on the impact of inflation on economic growth in nigeriacase studies on the economics of regulating agricultural biotechnologyexperimental studies on the survival of pathogens in frozen foodson the evaluation and comparison of taggerson the design and development of program familiesreviews on the book three cups of teaon the net mass balance of the glaciers and ice caps in svalbard norwegian arcticon the features and challenges of security and privacy in distributed internet of thingswhat is recorded on the financial capital account of the balance of paymentsenglish language test at b1 level on the common european framework of reference cefron the status and purposes of ancient egyptian artthe impact of capital market on the growth and development of nigerian economywrite an essay on the origin and tradition of drama in english literaturethe moderating effect of product knowledge on the learning and organization of product informationnote on the implementation and monitoring of livelihood programsBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ