Muscarinic mechanisms in a mouse model of myopia 1

... gallamine or alcuronium) Since then an increasing number of allosteric ligands that can decrease or increase in a subtype-specific manner classical muscarinic agonist and antagonist binding affinity ... acts as a retinal neurotransmitter and may interact with dopaminergic mechanisms (Brown and Rietow 19 81) Pharmacological studies of muscarinic agents are interesting and impo...

Ngày tải lên: 16/09/2015, 08:31

... treated and saline treated sclera Lane 1: 100 bp DNA ladder, lane 2: atropine treated myopic sclera, lane 3: atropine treated control sclera, lane 4: saline treated myopic sclera, lane 5: saline ... sclera and atropine treated experimental myopic sclera, atropine treated contra lateral control sclera, normal saline treated experimental myopic sclera and normal saline treated contra lateral ....

Ngày tải lên: 16/09/2015, 08:31

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...

Ngày tải lên: 12/08/2014, 14:20

... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expr...

Ngày tải lên: 14/08/2014, 08:20

... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray pl...

Ngày tải lên: 14/08/2014, 20:22

... anhydrases CA I and CA IV and aquaporins Aqp4 and Aqp8 [78-80] These results indicate that infectious diarrhea and noninfectious inflammationassociated diarrhea may have common mechanisms of pathogenesis ... adult mouse gastrointestinal tract identified by microarray analysis Gastroenterology 2002, 122:1467-1482 Bekku S, Mochizuki H, Takayama E, Shinomiya N, Fukamachi H, Ichinose M, Tad...

Ngày tải lên: 14/08/2014, 20:22

... has been identified as a key proinflammatory mediator in experimental acute pancreatitis (AP) SP is a product of the preprotachykinin -A (PPTA) gene, and it binds mainly to neurokinin- 1 receptor ... either an aromatic or an aliphatic amino acid (Severini et al., 2002) Tachykinins are produced by three genes in mammals, namely preprotachykinin A (PPTA), preprotachykini...

Ngày tải lên: 09/09/2015, 17:54

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... resulting in intracellular ionic imbalance and activation of the inflammasome (Ichinohe et al 2010) Although influenza infection results in activation of the inflammasome in both lung stromal and ... ciliated epithelium results in initial shrinkage and vacuolaization of the cells, culminating in necrosis and eventual desquamation of these cells into the luminal space The...

Ngày tải lên: 10/09/2015, 15:53

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...

Ngày tải lên: 14/09/2015, 08:42