Muscarinic mechanisms in a mouse model of myopia 1
Muscarinic mechanisms in a mouse model of myopia 1
... gallamine or alcuronium) Since then an increasing number of allosteric ligands that can decrease or increase in a subtype-specific manner classical muscarinic agonist and antagonist binding affinity ... acts as a retinal neurotransmitter and may interact with dopaminergic mechanisms (Brown and Rietow 19 81) Pharmacological studies of muscarinic agents are interesting and impo...
Muscarinic mechanisms in a mouse model of myopia 2
... treated and saline treated sclera Lane 1: 100 bp DNA ladder, lane 2: atropine treated myopic sclera, lane 3: atropine treated control sclera, lane 4: saline treated myopic sclera, lane 5: saline ... sclera and atropine treated experimental myopic sclera, atropine treated contra lateral control sclera, normal saline treated experimental myopic sclera and normal saline treated contra lateral ....
Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf
... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx
... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...
Báo cáo y học: " Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma" doc
... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...
Báo cáo y học: " GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma" ppt
... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...
Báo cáo y học: " Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa" docx
... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expr...
Báo cáo y học: "Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)" pot
... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray pl...
Báo cáo y học: "Diarrhea as a cause of mortality in a mouse model of infectious colitis" ppt
... anhydrases CA I and CA IV and aquaporins Aqp4 and Aqp8 [78-80] These results indicate that infectious diarrhea and noninfectious inflammationassociated diarrhea may have common mechanisms of pathogenesis ... adult mouse gastrointestinal tract identified by microarray analysis Gastroenterology 2002, 122:1467-1482 Bekku S, Mochizuki H, Takayama E, Shinomiya N, Fukamachi H, Ichinose M, Tad...
Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis
... has been identified as a key proinflammatory mediator in experimental acute pancreatitis (AP) SP is a product of the preprotachykinin -A (PPTA) gene, and it binds mainly to neurokinin- 1 receptor ... either an aromatic or an aliphatic amino acid (Severini et al., 2002) Tachykinins are produced by three genes in mammals, namely preprotachykinin A (PPTA), preprotachykini...
Gene expression changes in the brainstem and prefrontal cortex in a mouse model of orofacial pain
... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...
The role of interferon gamma in regulating antigen specific CD8 t cell responses in a mouse model of influenza
... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel 10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...
Characterisation of lung dendritic cell function in a mouse model of influenza
... resulting in intracellular ionic imbalance and activation of the inflammasome (Ichinohe et al 2010) Although influenza infection results in activation of the inflammasome in both lung stromal and ... ciliated epithelium results in initial shrinkage and vacuolaization of the cells, culminating in necrosis and eventual desquamation of these cells into the luminal space The...
Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain
... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...
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