Angiotension receptors subtypes in the rabbit pulmonary artery

... Angiotensin II-induced increase in intracellular Ca results in binding of Ca to calmodulin Association of the Ca-calmodulin complex with myosin light chain kinase (MLCK) causes MLCK activation and the ... inhibiting intracellular signals integrating incoming extracellular signals where Ca2+ is just one, albeit important, player The angiotensin II-induced increase in intracellular...

Ngày tải lên: 15/09/2015, 22:09

... [4,5,26] The P 2Y1 , P 2Y2 , P 2Y4 , P 2Y6 and P 2Y1 1 receptors all couple to the Gq/11 G proteins, leading to the release of IP3-sensitive Ca2+ stores [14] and so could, if present in the tissue, mediate ... variation in the P 2Y subtype distribution Thus, multiple subtypes of P 2Y receptor are widely expressed in pulmonary artery smooth muscle and are...

Ngày tải lên: 12/08/2014, 18:20

... Lack of bioequivalence of two oxytetracycline formulations in the rabbit 27 Fig Mean concentration-time profiles of oxytetracycline in rabbit plasma after oral administration of a single dose of ... different in rabbits The dicrepancy in these pharmackinetic parameters between two OTC products is the topic of further study in the future The fact tha...

Ngày tải lên: 07/08/2014, 15:20

... interfering of disc degenerationchanges after injection of control small interfering RNA (siRNA) or ADAMTS5 siRNA in the rabbit anular puncture model of disc degeneration Eight weeks after the control ... degeneration interfering RNA (siRNA) injection in assessment weeks after small Magnetic resonance imaging (MRI) the rabbit anular puncture m...

Ngày tải lên: 09/08/2014, 14:22

... transient but significant effects in patients with pulmonary arterial hypertension In this study we explored the molecular effects of statins on distal human pulmonary artery smooth muscle cells (PASMCs) ... of statins on DNA synthesis in human PASMCs (A-B) Inhibition of DNA synthesis, assessed by PDGF-stimulated (5 ng/ml) [3H-methyl]-thymidine incorporatio...

Ngày tải lên: 12/08/2014, 14:20

... representation of a rabbit placenta (right) and haematoxylin and eosin staining of a day 12 placenta section (left) with the main layers of the placenta indicated (B) Higher magnification of the areas framed ... Structure and in situ hybridization forand eosin staining of a dayof day 12 rabbit placenta: (A) Schematic representation placenta bit placenta (right)...

Ngày tải lên: 12/08/2014, 23:22

... Figure of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo The effect The effect of intra-portal injection of (a) ATP and (b) adenosine on ... portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and...

Ngày tải lên: 13/08/2014, 13:20

... regulated genes in the frontal cortex 48 Table 4: Down regulated genes in the frontal cortex 50 Table 5: Up regulated genes common in the middle cerebral artery and frontal cortex ... quantitatively and morphologically in 10 New Zealand White rabbits with and without hypertension, induced using the 2kidney, 1-clip Goldblatt hypertension model Genes i...

Ngày tải lên: 02/10/2015, 17:13

... thin layer of the adventitia were carefully stripped off with fine forceps, and the endothelium was removed by gently scratching the intimal surface with a surgical blade The remaining smooth muscles ... activation-induced constriction of pulmonary artery rings via the PLC-IP3 signal transduction pathway Both Ca2+ and Gd3+ evoked increases in tension of pulmonary ar...

Ngày tải lên: 10/08/2014, 05:21

... vital capacity; MEP = maximal expiratory pressure; MIP = maximal inspiratory pressure; CABG = coronary artery bypass graft; CAD = coronary artery disease; HV = healthy volunteers Pain may also contribute ... Antiarrhythmic drugs ASA Calcium channel antagonists CABG = coronary artery bypass graft; CAD = coronary artery disease; BMI = body mass index; AC = aortic clamping;...

Ngày tải lên: 10/08/2014, 09:21

... therapeutic effects (vasodilation/antiproliferation) of sildenafil was involved in inhibition of the SOC/Ca2+/NFAT pathway Additionally, activation PKG pathway by sildenafil and 8-brom-cGMP inhibited ... significantly reduces neomuscularization in hypoxia and monocrotaline models of pulmonary hypertension [2,33] Several studies concerning the remodeling process r...

Ngày tải lên: 12/08/2014, 14:20

... blood To that end, we measured the steady state concentration of oxygen and [Lac] in the central veins, the right heart chambers, and the pulmonary artery in hemodynamically stable individuals who ... mean SO2 and pulmonary arterial SO2 reported in published studies measuring SO2 in the central veins, the right heart, and pulmonary artery i...

Ngày tải lên: 13/08/2014, 03:20

... results of these initial trials indicate that the ZES is safe and reduces the rates of clinical and angiographic restenosis in patients with symptomatic coronary artery disease (CAD; 4) Also the safety ... Abbreviations ACC: American College of Cardiology; AHA: American Heart Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse...

Ngày tải lên: 25/10/2012, 11:18

... to thank Dr A. N Aggarwal (Associate Professor, Department of Pulmonary Medicine, PGIMER, Chandigarh) for his help in the biostatistical analysis of the data 2008; Vol 50 The Indian Journal of ... physicians and an incorrect initial diagnosis of TB is associated with the potential risk of delay in the institution of ATT and there by facilitates silent spread of...

Ngày tải lên: 15/02/2014, 13:20

... only the longest amino acid sequences that included the DNA binding, hinge and ligand-binding domains were used for this analysis, except for the Knirps family members that lack the LBD In D ... processes In A aegypti, the discrete expression of both AaHR3 and AaHR4 suggests their function in the regulatory hierarchy in the mosquito fat body during vitellogenesi...

Ngày tải lên: 18/02/2014, 13:20