Anti tumor mechanisms of luteolin, a major flavonoid of chrysanthemum morifolium

... protein-1 Apaf-1 apoptotic protease-activating factor ATM ataxia telangiectasia mutated kinase ATR ataxia telangiectasia and Rad3-related kinase BIM bisindolylmaleimide I CARD caspase recruitment domains ... activated sequentially Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3related kinase (ATR) are activated very rapidly and then activate p53, which eventurely...

Ngày tải lên: 15/09/2015, 17:11

... primary colon carcinoma before start of the NK cell-based therapy, the anastomotic relapse before start of the NK cell-based therapy and the duodenom metastases after finishing the NK cell-based ... line phosphatase, γ-glutamine transferase, alanine aminotranferease (ALT), aspartate aminotransferase (AST), lactate dehydrogenase, Quick, and aPTT were determined before each le...

Ngày tải lên: 18/06/2014, 15:20

... the alginate-encapsulate tumor cell assay Angiogenesis in alginate implants was quantified by measuring the uptake of FITC-dextran into the beads Vascularization of alginate beads was apparently ... delivered by an attenuated strain of Salmonella typhimurium[29] Plasmid DNA vaccines are attractive because they are relatively easy to engineer and produce, and are safe to administer t...

Ngày tải lên: 14/08/2014, 19:22

... activated caspase resulting in release of cytochrome c from the mitochondria and subsequent activation of caspase and amplification of the caspase activation cascade downstream of the mitochondria ... sufficient activation of caspase to induce a direct amplification of the caspase activation cascade that involve downstream caspases like caspase 3, caspase and caspase Cel...

Ngày tải lên: 14/09/2015, 18:22

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial...

Ngày tải lên: 10/08/2014, 05:21

... ANTI- TUMOR PROPERTIES OF LACTOBACILLI ARE MEDIATED BY IMMUNO- MODULATION AND DIRECT CYTOTOXICITY CAI SHIRONG B.Sc (Hons), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... the anti- tumor properties of LGG and compare it with that of other lactobacillus strains The study is divided into main areas: I Immuno- modulation by lactobaci...

Ngày tải lên: 11/09/2015, 09:16

... 1 .3. 4 Other regulatory mechanisms 30 1 .3. 5 Apoptosis and cancer 30 1 .3. 6 TRAIL signaling pathway as potential therapeutic target 32 Objectives of the study Chapter Materials and Methods 33 34 ... accompanying p 53 up-regulation 51 3. 4 I3M causes Bid cleavage 55 3. 5 I3M induces Bax conformational changes 59 3. 6 I3M induces cytochrome c release 63 v 3. 7 3. 8 Overexpr...

Ngày tải lên: 30/09/2015, 13:41

... mark, emphases the possibility that numerous other natural compounds can take the same pathways leading to apoptosis apoptosis in colorectal cancer by activation of p53 and p73 which are negative ... carcinoma cells Anticancer Drugs 2003, 14:193-202 103 Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, Tajima H, Fujita H, Takamura H, Ninomiya I, Fujimura T, Ohta T, Yashiro M,...

Ngày tải lên: 10/08/2014, 10:21

... Baune and Eyre: Anti-inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis: a case report Journal of Medical Case ... for the antipsychotic treatment Eur Neuropsychopharmacol 1999, 10(1):1-4 Sugino H, Futamura T, Mitsumoto Y, Maeda K, Marunaka Y: Atypical a...

Ngày tải lên: 11/08/2014, 14:21

... set There are 1,364 and 1,323 gene pairs in human and mouse, respectively, in the FAM2 gene set deposited research TAGs are tandemly arrayed genes that belong to the same gene family There are ... of the human gene pairs and 91% of the mouse gene pairs in the NEW gene set have Ks ≤ 0.25, which confirms the recent duplications of these gen...

Ngày tải lên: 14/08/2014, 08:20

... A STUDY INTO THE DIFFERENT MECHANISMS OF ANTICANCER EFFECT OF DOCOSAHEXANOIC ACID IN COLON CANCER CELLS MANAV (B MED, GSMU, INDIA) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT ... increased the polyp number in both the small and large intestines, suggesting that fatty acids may activate other pathways also in addition to PPARγ...

Ngày tải lên: 26/09/2015, 09:57

... [106,107] A step forward in the analysis of Fe(III)-OO(H) as a potential catalyst was thought to be offered by the use of mutated P450s, bearing alanine or some other amino acid in place of the highly ... Hlavica, P (1983) Mechanisms of extrahepatic bioactivation of aromatic amines: the role of hemoglobin in the N-oxidation of 4-chloraniline In Extr...

Ngày tải lên: 19/02/2014, 16:20

... MIR-D40 (Sanyo, Osaka, Japan) To amplify the DNA fragments containing a complete x-5 gliadin gene, oligonucleotides, 5¢-AAGTGAGCAATAGTAAACACAAATCAAAC-3¢ and 5¢-CGTTACATTATGCTCCATTGACTAACAACGA TG-3¢, ... on autoradiography film Dot blot immunoassay for inhibition test Expression and purification of recombinant protein Sense (5¢-ATTTCATATGCAACAACAATTCCCCCAGC AACAATCA-3¢) and antis...

Ngày tải lên: 20/02/2014, 01:20

... recombinant strains obtained from a cross involving CS9 and IJ2 parental strains ability of GBSSI to extend amylopectin outer chains Again this coincides with a decrease in crystallinity This situation ... most polysaccharide synthesis At this stage the rate of amylopectin synthesis has become minimal and it is difficult to say if the residual amylopectin synthesis activity is du...

Ngày tải lên: 22/02/2014, 07:20

... from the liver of yellowtail, and found that the one-sided accumulation of arachidonic acid into PtdIns is attained in the presence of large amounts of docosahexaenoic acid and that several acyltransferase ... clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of fish Fig Effects of docosahexaenoic acid (D...

Ngày tải lên: 08/03/2014, 08:20