Studies on the intracellular signalling pathways triggered by the anaphylatoxin c5a in human phagocytic cells 1

... I 1. 1 INTRODUCTION 1. 1 .1 Complement proteins and nomenclature 1. 1.2 Activation of the complement cascade 1. 1.2 .1 The classical pathway 1. 1.2.2 The alternative pathway 1. 1.2.3 The mannan-binding ... ligand C5a 11 1. 1.5.3 Complement 5a receptor (C5aR) 13 1. 1.5.4 Role of C5a in diseases 1. 2 The complement system 16 Important downstream events triggered...

Ngày tải lên: 14/09/2015, 21:55

... levels of liver enzymes aspartate aminotransferase and alanine aminotransferase), circulatory failure, accompanied by thrombocytopenia and haemoconcentration Complications such as gastrointestinal ... and international air and sea travel Dengue viruses are transmitted to human beings through the bite of infected mosquitoes of the Aedes genus (Ae aegypti and Ae albopict...

Ngày tải lên: 13/10/2015, 16:41

... Achilles tendon Tendon segments Flexor tendon cells MCL scar explants ACL cells Tendon cells Achilles tendon Enhance neo-vascularization and the formation of granulation tissue Increase the stiffness ... Muscle tendon junction Vascular walls, Muscle tendon junction Type I collagen has predilection to form parallel fibers One collagen type I molecule consists of...

Ngày tải lên: 17/09/2015, 17:18

... endocannabinoid system, we investigated the presence and regulation of endocannabinoids, cannabinoid receptors and FAAH in immature and mature dendritic cells obtained by stimulation with either the ... min), two fractions were obtained: a top leukocyte band containing mononuclear cells (monocytes and lymphocytes) and a lower band containing polymorphonuclear le...

Ngày tải lên: 22/02/2014, 07:20

... investigated the effect of PF -4 on another angiogenic factor of prime importance, VEGF, and compared the mechanisms by which PF -4 inhibits the DNA synthesis induced by VEGF165 and VEGF121 The DNA synthesis ... [26] and (b) PF -4 inhibits the DNA synthesis induced by VEGF165 and VEGF121 PF -4 does not affect VEGF121 -induced KDR phosphorylation We analy...

Ngày tải lên: 19/02/2014, 16:20

... during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression of cell cycle controlling ... with genistein 10 μM and irradiation with Gy together, the effects of genistein on survival in these cell lines seem to be independent of ER- and p...

Ngày tải lên: 09/08/2014, 09:22

... responses triggered by the activation of the TCR, it is therefore of crucial importance to understand the multi-step signaling cascade triggered by the TCR activation During the last few years it has ... degradation of the pseudosubstrate resulting in release of autoinhibitory interactions between the regulatory and kinase domains of the enzyme The activation of...

Ngày tải lên: 11/09/2015, 09:05

... (Sacc.)Nirenberg,isolateAG11iwereutilizedforexaminingtheeffectsofthedifferent factorsontheinfectionofFusariumintomaizeleaves .F. graminearumwasincludedin theexperimentoneffectofinoculationsitesofFusariuminfectionandmanifestationof symptomsonmaizeplants.Theseisolateswereobtainedfromtheculturecollectionof ... and cultivar on the infection of Fusariumspeciesintomaizeleaves. ii examinet...

Ngày tải lên: 19/11/2015, 16:47

... 6A,B) In the present study, we compared the functional roles of the N- and C-terminal regions of 4482 H Tanaka et al molluskan and vertebrate TnI and revealed for the first time that (a) the alternative ... of the troponin complex In molluskan muscles, the C-terminal region does not function and troponin regulates contraction only through the act...

Ngày tải lên: 20/02/2014, 01:20

... group of Glu207 into phytoene (the main labeled component of the lipidsoluble fraction) is systematically diminished by the addition of increasing amounts of [1-3H ]2C-methyl-D -erythritol 4-phosphate ... Formation of 4-(cytidine 50 -diphospho)-2-C-methyl-D -erythritol from 2-C-methyl-D -erythritol 4-phosphate by 2-C-methyl-D -erythritol 4-phosphate cytidyltran...

Ngày tải lên: 22/02/2014, 07:20

... regions of the state On the other hand, only a small fraction of those claiming the tax credit take advantage of the low-interest loan Furthermore, the property-tax exemption complements the ... National Laboratory, Matthew Brown of the National Conference of State Legislatures, Jane Weissman of the Interstate Renewable Energy Council, Frederick Beck of...

Ngày tải lên: 06/03/2014, 19:20

... co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R1–YFP – genetic variant of dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein (D1 CFP and D2R2–YFP ... two dopamine D2 receptor fusion proteins (D2 CFP and D2 YFP) f Measured in cell co-expressing two dopamine D2 receptor fusion proteins (D2 CFP...

Ngày tải lên: 07/03/2014, 03:20

... to thrombin and upstream of aIIbb3 activation GPIb plays an important role in platelet activation by low thrombin concentrations and therefore at the start of the haemostasis process when trace ... PPACKthrombin and is involved in platelet platelet interactions, in agreement with the observations of Ramakrishnan et al [11] using GPV null mouse platelets In contrast, platelet...

Ngày tải lên: 08/03/2014, 02:21

... above, these initial conditions were rapidly conducive to steady conditions where and were present in very similar concentrations, and the rates of the forward reaction (conversion of to 3) and the ... Discussion The main part of the present study was a search, under conditions of maximal stringency, for fragment exchange that could be the hallmark of the hypothetical...

Ngày tải lên: 16/03/2014, 06:20

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the...

Ngày tải lên: 16/03/2014, 10:20