A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3

... 4 32 .155 32 .32 7 32 .414 32 .472 32 .541 32 .802 32 . 933 33 . 031 33 .185 33 .34 0 33 .37 6 33 .409 33 .467 33 .6 83 33. 718 33 . 739 33 .769 33 .848 33 .864 33 .952 34 .026 34 .065 34 .160 34 . 230 34 .36 3 34 .544 34 .659 34 .948 ... 34 .948 35 .117 35 .240 35 .277 35 .32 4 35 .486 35 .587 32 .166 32 .39 2 32 .4 43 32.485 32 .557 32 . 832 32 .941 33 .071 33 .194 33 .36 6 33 .38 8 33 .419 33 .546 33 .696 33 .728 33 .752 33 .788 33 .858 33 .880 33 .966 34 . 034 34 .068 ... Results 3. 1 First Generation Linkage Disequilibrium and Haplotype Map of the Chromosome 6p and the Major Histocompatibility Complex To characterize the genetic variation and patterns of linkage disequilibrium...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2

... CTT AAg TT DRB1-09 CAg gAA ACA gCT ATg ACC TgA CCA gCA CgT TTC TTg AAg CAg gAT AAg TT DRB1- 52. 1 CAg gAA ACA gCT ATg ACC CCC ACA gCA CgT TTC TTg gAg TAC YCT A DRB1-07 CAg gAA ACA gCT ATg ACC TgA ... TTA gg CTg AAT gAA CCC TgC TCT gg TgA ATA ACA AAT ggg CAA ACC CCT AAg AAT gTg CCC TgT CC gAg CAA Agg gCT gAA gAT TAT g ACT CTg CCT TTC CTC ATC AAA C TCC TCA TCA ACA CCA CTT TCT g TCC CAA ggA ... Agg AAA CAg CTT ATg ACC TgA gAC gCA CgT TTC TTg gAg CAg gTT AAA C DRB1-01 DRB1 CAg gAA ACA gCT ATg ACC TgA AgA CCA CgT TTC TTg gAg gAg g CAg gAA ACA gCT ATg ACC TgA gAC gCA CgT TTC TTg Tgg SAg...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4

... Variation Map of the MHC For constructing a fine-scale variation map of the MHC, 2360 SNPs were genotyped in 2 84 Singaporean Chinese individuals The bulk of these samples consisted of 2 14 randomly ... variation in the MHC, r2 values between the 1877 SNPs used and the remaining HapMap SNPs within the MHC locus, were calculated using the genotype data of the HapMap Han Chinese population Panel ... also generated by treating the East Asian panels as a single population (Chinese and Japanese) as well as all panels as a whole The 102 Results transferability of each set of tag SNPs was assessed...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5

... and the haplotype that tags a HLA allele with the maximum r2 was taken as the tagging haplotype for that particular allele The results are shown in Table 3.9 Using single-SNP tags, most HLA alleles ... (Svensson and Andersson 1997, Bergström et al 1999) Based on their DRB1 alleles, almost all of the DR haplotypes in the local Chinese population fall into of haplotypes (DR8, DR51, DR52 and DR53) The ... tags and indicating that these tags not only apply to the local Chinese population The DR52 and DR53 haplotype alignments are expanded in Figure 3.24 and illustrate the different resolution of...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6

... A2 -B 46- DR9 haplotypes, with 65 % of the haplotypes carrying the allele ‘G’ and the rest carrying the allele A This SNP lies within an intron of the PPP1R10 gene, bordering an AluJb transposable ... within the conserved haplotype A lack of detailed knowledge of the variation and allelic content of the CEHs beyond the HLA genes has hampered finemapping of disease loci To this end, the MHC haplotype ... identified in the HapMap project (International HapMap Consortium 2005) At the telomeric end, a single chromosome breaks at position 29,591,947; again this location is close to a HapMap recombination...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7

... A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A T T T T T T T T T T T T A A A A A A A A A A A A A ... A A A A A A A A A A A A A A A A A A A G G G G G G G G G G G G A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A ... A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A G G G G G G G G G G G G G G G G G G A A A A A A A A A...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 8

... LD and Variation of the MHC in Singaporean Chinese Many association studies have highlighted strong links between the MHC and a number of diseases in the Singaporean Chinese population, and a ... available variation data in other regions of the genome for the Singaporean Chinese population, the CHB panel of the HapMap project will serve as an adequate proxy The correlation of the Singaporean ... studies in the local Chinese population Strong correlation in SNP profile of two Asian populations – that of Singaporean Chinese and the Han Chinese in Beijing The HapMap project has become an important...

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 1

... Population HLA -A HLA-DRB1 Frequency A* 010 1 A* 03 01 A* 02 01 A* 26 01 A* 02 01 A* 310 1 A* 30 01 A* 02 01 1.2.7 HLA-B B*08 01 B*0702 B*4402 B*38 01 B *15 01 B*40 01 B *18 01 B *15 01 DRB1*03 01 DRB1 *15 01 DRB1*04 01 DRB1*0402 ... Townsend and Drakesmith 2002) Physical mapping of HFE places it at location 26.2Mb of the chromosome 6p, a distance of 3.8Mb away from HLA -A MHC haplotypes carrying the HLA -A3 allele in Caucasians are ... transferability of the variation data, LD patterns, haplotype blocks and tag SNPs identified in the HapMap project to other distinct populations such as the Singaporean Chinese 15 Introduction 1. 2.4...

Báo cáo y học: "Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map" doc

... with the physical and genetic maps of Trypanosoma brucei brucei Comparison Comparison with the physical and genetic maps of Trypanosoma brucei brucei The genetic maps of T b brucei isolate TREU ... the salivary glands (transmission index), and in their ability to resist killing by a number of trypanocidal drugs used in the treatment of human African trypanosomiasis [18] The availability ... Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which are the cause of sleeping sickness in humans; and the nonhuman infective Trypanosoma brucei brucei subspecies Over the past...

Báo cáo y học: "Genomic linkage map of the human blood fluke Schistosoma mansoni" doc

... than 70% of the 381 Mb in version 3.1 of the genome assembly; by placing markers in these scaffolds the majority of the genome sequence can be ordered on linkage groups by examining their segregation ... for 86% (1,134 of 1,320 cM) of the total genetic map length The genome assembly will benefit from the broad coverage of the map, high density of markers, and placement of previously unanchored ... informationmapped ofmore informaand list each in mapped BACs that onelinkage map statistics, A texthere FISH the usedofdocumentfile Summaryworksheet Clickmarkers of markers usedoflinkage map orderingtothat...

Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

... binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancer The association between any variant in the ATM gene and risk of breast ... mutations of either one of the three serine residues (367, 1893 and 1981) give rise to proteins defective in ATM signalling in vivo [24] Studies of linkage disequilibrium (LD) patterns of the ATM gene ... variation in the ATM gene where combined into one group The level of adverse side effects in the Norwegian breast cancer patients or risk of IBTR in the American breast cancer cases were then Page of...

Báo cáo y học: "A comprehensive transcript index of the human genome generated using microarrays and computational approaches" pdf

... sequencing and comparative analysis of the mouse genome Nature 2002, 420:520-562 Supporting online material for: A comprehensive transcript index of the human genome generated using microarrays and computational ... generate a comprehensive transcript index (CTI) for the human genome The first step is the assembly of a comprehensive set of annotations to generate a predicted transcript index (PTI) Sets of microarrays ... Escherichia coli genomes The recent sequencing and analysis of the mouse genome indicates extensive homology between intergenic regions of the human and mouse genomes, further highlighting the potential...

Báo cáo khoa hoc:"The porcine Major Histocompatibility Complex and related paralogous regions: a review" ppsx

... in protection against malaria caused by Plasmodium falciparum has been clearly shown, and recent results strongly indicate a host-parasite coevolution HLA class II alleles have also been suggested ... the spontaneous reappearance of the malignant melanoma also seemed to correlate with an ancestral SLA haplotype [22] In contrast, segregation analysis of melanocytic 124 P Chardon et al lesions ... optimal activity at acidic pH valyl tRNA synthetase MutS homologue a ects testicular size and ovarian structure prolin-rich protein with novel repeat elements allograft inﬂammatory factor-1 also...

Báo cáo y học: " A cross-sectional testing of The Iowa Personality Disorder Screen in a psychiatric outpatient setting" pot

... PDs in bivariate analysis A new finding is that only the IPDS score remained significant in the multivariate analysis Our interpretation of these results is that psychological and functional variables ... statistical analyses and helped to draft the manuscript AAD participated in the design, performed statistical analyses and helped to draft the manuscript of the study All authors have read and ... fit value Page of We found that the GSI and the GAF-S as measures of psychopathology and the GAF-F as a measure of function as well as the IPDS were significantly associated with the presence of...

Báo cáo y học: "A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection" doc

... measurements Table Primers for Q RT-PCR Primer Alias Sequence 1082 ACT1F GCCTTCTACGTTTCCATCCA 1083 ACT1R GGCCAAATCGATTCTCAAAA 1367 PAC2F AATAACGAATTGAGCTATGACACCAA 1368 PAC2R AGCTTACTCATATCGATTTCATACGACTT ... of BNA2, intracellular NAD+ levels may be maintained by the NAD+ salvage pathway Further experiments are required to determine the mechanism by which BNA2 affects telomere capping and whether ... order to validate the microarray data, we used quantitative RT-PCR to examine the expression of five of the up-regulated genes in a set of RNA samples that had been used in the array analysis (Figure...

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Từ khóa: the major histocompatibility complex a paradigm for studies of the human genome show me a map of the time zones in the united states of america design or of line drawing if you like to use this term is the source and very essence of painting sculpture architecture sometimes it seems to me that all the works of the human brain and hand are either design itself or a branch of that art design like good painting cooking architecture or whatever you like is a manifestation of the capacity of the human spirit to transcend its limitations cain s reason was for building a city so early in the history of the human race • building a european facility to simulate the working of the human brain by developing and using supercomputers and neuromorph a road map of the book the interaction of antigens and superantigens with the human class ii major histocompatibility complex molecule hla dr1 studies of therapeutic strategies for atrial fibrillation based on a biophysical model of the human atria the cardiac atlas project towards a map of the heart a map of the limits of statistics u chu r huang q castellon r yeldandi av reddy jk 1996 identification of a peroxisome proliferator responsive element upstream of the human peroxisomal fatty acyl coenzyme a oxidase gene j biol chem 271 2147 2155 h kim m lee kh kang kn lee st 1998 exon intron structure of the human ptk6 gene demonstrates that ptk6 constitutes a distinct family of non receptor tyrosine kinase mol cells 8 4 401 7 map of the ponte are stimulated by extracellular matrix proteins such as type i collagen previous studies have demonstrated the involvement of a dggryy sequence located within the a1 chain cterminal telopeptide in type i collageninduced pmn activation Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit ĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Trả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chế Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tin Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khí Chuong 2 nhận dạng rui ro BT Tieng anh 6 UNIT 2 Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘI Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015 QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ