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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2

... CTT AAg TT DRB1-09 CAg gAA ACA gCT ATg ACC TgA CCA gCA CgT TTC TTg AAg CAg gAT AAg TT DRB1- 52. 1 CAg gAA ACA gCT ATg ACC CCC ACA gCA CgT TTC TTg gAg TAC YCT A DRB1-07 CAg gAA ACA gCT ATg ACC TgA ... TTA gg CTg AAT gAA CCC TgC TCT gg TgA ATA ACA AAT ggg CAA ACC CCT AAg AAT gTg CCC TgT CC gAg CAA Agg gCT gAA gAT TAT g ACT CTg CCT TTC CTC ATC AAA C TCC TCA TCA ACA CCA CTT TCT g TCC CAA ggA .....

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3

... 4 32 .155 32 .32 7 32 .414 32 .472 32 .541 32 .802 32 . 933 33 . 031 33 .185 33 .34 0 33 .37 6 33 .409 33 .467 33 .6 83 33. 718 33 . 739 33 .769 33 .848 33 .864 33 .952 34 .026 34 .065 34 .160 34 . 230 34 .36 3 34 .544 34 .659 34 .948 ... 34 .948 35 .117 35 .240 35 .277 35 .32 4 35 .486 35 .587 32 .166 32 .39 2 32 .4 43 32.485 32 .557 32 . 832 32 .941...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4

... Variation Map of the MHC For constructing a fine-scale variation map of the MHC, 2360 SNPs were genotyped in 2 84 Singaporean Chinese individuals The bulk of these samples consisted of 2 14 randomly ... variation in the MHC, r2 values between the 1877 SNPs used and the remaining HapMap SNPs within the MHC locus, were calculated using the genotype data...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5

... and the haplotype that tags a HLA allele with the maximum r2 was taken as the tagging haplotype for that particular allele The results are shown in Table 3.9 Using single-SNP tags, most HLA alleles ... (Svensson and Andersson 1997, Bergström et al 1999) Based on their DRB1 alleles, almost all of the DR haplotypes in the local Chinese population fall into of hapl...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6

... A2 -B 46- DR9 haplotypes, with 65 % of the haplotypes carrying the allele ‘G’ and the rest carrying the allele A This SNP lies within an intron of the PPP1R10 gene, bordering an AluJb transposable ... within the conserved haplotype A lack of detailed knowledge of the variation and allelic content of the CEHs beyond the HLA genes has hampered finemappin...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7

... A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A T T T T T T T T T T T T A A A A A A A A A A A A A ... A A A A A A A A A A A A A A A A A A A G G G G G G G G G G G G A A A A A A A A A A...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 8

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 8

... LD and Variation of the MHC in Singaporean Chinese Many association studies have highlighted strong links between the MHC and a number of diseases in the Singaporean Chinese population, and a ... available variation data in other regions of the genome for the Singaporean Chinese population, the CHB panel of the HapMap project will serve as an adequa...

Ngày tải lên : 14/09/2015, 14:07

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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 1

A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 1

... Population HLA -A HLA-DRB1 Frequency A* 010 1 A* 03 01 A* 02 01 A* 26 01 A* 02 01 A* 310 1 A* 30 01 A* 02 01 1.2.7 HLA-B B*08 01 B*0702 B*4402 B*38 01 B *15 01 B*40 01 B *18 01 B *15 01 DRB1*03 01 DRB1 *15 01 DRB1*04 01 DRB1*0402 ... Townsend and Drakesmith 2002) Physical mapping of HFE places it at location 26.2Mb of the chromosome 6p, a distance of 3.8Mb...

Ngày tải lên : 14/09/2015, 14:07

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Báo cáo y học: "Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map" doc

Báo cáo y học: "Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map" doc

... with the physical and genetic maps of Trypanosoma brucei brucei Comparison Comparison with the physical and genetic maps of Trypanosoma brucei brucei The genetic maps of T b brucei isolate TREU ... the salivary glands (transmission index), and in their ability to resist killing by a number of trypanocidal drugs used in the treatment of human Afric...

Ngày tải lên : 14/08/2014, 20:22

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Báo cáo y học: "Genomic linkage map of the human blood fluke Schistosoma mansoni" doc

Báo cáo y học: "Genomic linkage map of the human blood fluke Schistosoma mansoni" doc

... than 70% of the 381 Mb in version 3.1 of the genome assembly; by placing markers in these scaffolds the majority of the genome sequence can be ordered on linkage groups by examining their segregation ... for 86% (1,134 of 1,320 cM) of the total genetic map length The genome assembly will benefit from the broad coverage of the map, high density of markers, an...

Ngày tải lên : 14/08/2014, 21:20

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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

... binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancer The association between any variant in the ATM gene and risk of breast ... mutations of either one of the three serine residues (367, 1893 and 1981) give rise to proteins defective in ATM signalling in vivo [24] Studies of l...

Ngày tải lên : 09/08/2014, 10:21

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Báo cáo y học: "A comprehensive transcript index of the human genome generated using microarrays and computational approaches" pdf

Báo cáo y học: "A comprehensive transcript index of the human genome generated using microarrays and computational approaches" pdf

... sequencing and comparative analysis of the mouse genome Nature 2002, 420:520-562 Supporting online material for: A comprehensive transcript index of the human genome generated using microarrays and computational ... generate a comprehensive transcript index (CTI) for the human genome The first step is the assembly of a comprehensive set of...

Ngày tải lên : 14/08/2014, 14:21

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Báo cáo khoa hoc:"The porcine Major Histocompatibility Complex and related paralogous regions: a review" ppsx

Báo cáo khoa hoc:"The porcine Major Histocompatibility Complex and related paralogous regions: a review" ppsx

... in protection against malaria caused by Plasmodium falciparum has been clearly shown, and recent results strongly indicate a host-parasite coevolution HLA class II alleles have also been suggested ... the spontaneous reappearance of the malignant melanoma also seemed to correlate with an ancestral SLA haplotype [22] In contrast, segregation analysis of melanocytic 124 P Chardon et al lesi...

Ngày tải lên : 09/08/2014, 18:21

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Báo cáo y học: " A cross-sectional testing of The Iowa Personality Disorder Screen in a psychiatric outpatient setting" pot

Báo cáo y học: " A cross-sectional testing of The Iowa Personality Disorder Screen in a psychiatric outpatient setting" pot

... PDs in bivariate analysis A new finding is that only the IPDS score remained significant in the multivariate analysis Our interpretation of these results is that psychological and functional variables ... statistical analyses and helped to draft the manuscript AAD participated in the design, performed statistical analyses and helped to draft the manuscript of the study...

Ngày tải lên : 11/08/2014, 15:22

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Báo cáo y học: "A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection" doc

Báo cáo y học: "A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection" doc

... measurements Table Primers for Q RT-PCR Primer Alias Sequence 1082 ACT1F GCCTTCTACGTTTCCATCCA 1083 ACT1R GGCCAAATCGATTCTCAAAA 1367 PAC2F AATAACGAATTGAGCTATGACACCAA 1368 PAC2R AGCTTACTCATATCGATTTCATACGACTT ... of BNA2, intracellular NAD+ levels may be maintained by the NAD+ salvage pathway Further experiments are required to determine the mechanism by which BNA2 affects telome...

Ngày tải lên : 14/08/2014, 21:20

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