Developing high throughput amenable chemistry for chemical biology applications

... DEVELOPING HIGH- THROUGHPUT AMENABLE CHEMISTRY FOR CHEMICAL BIOLOGY APPLICATIONS RAJAVEL SRINIVASAN (M.Sc., Anna University, Chennai, India) A THESIS SUBMITTED FOR THE DOCTOR OF ... Srinivasan, R.; “Highthroughput amenable Chemistry in Catalomics” A*STARNoyori Forum Joint Symposium on Organic Chemistry Singapore, May 2007 Srinivasan, R.; “Highthroughput amenable Ch...

Ngày tải lên: 14/09/2015, 14:05

... overview of applications of high- throughput technologies in chemical proteomics Much attention will be focused on studies of high- throughput strategies for proteomic profiling of aspartic proteases ... Objectives The aim of this thesis is to develop high- throughput amenable strategies for chemically profiling of aspartic proteases as well as protei...

Ngày tải lên: 10/09/2015, 15:49

... manual and automated analysis Correlation between manual and automated analysis In this evaluation, 45 experiments (each consisting of two microscopic slides) were analyzed by a human expert as well ... Binarize enhanced image based on color saturation • Classifiy object on axis of maximum discriminance • Transform feature vector into one dimension via LDA Figure Image an...

Ngày tải lên: 12/08/2014, 05:20

... research of genomics and genetics, more and more high- throughput data is available.  The first section (Section 1.1) of this chapter gives an overview of endothelial permeability and related disease ... mathematical modeling of signaling pathways (Section 1.2) The following sections of this chapter introduce the disease biomarker selection using high thr...

Ngày tải lên: 09/09/2015, 10:14

... relapse In conclusion, DNA chip platform is a high- throughput and reliable technology for genetic diagnosis and pharmacogenetic profiling ix LIST OF TABLES Page Table 1.1 Features of traditional ... severe anaemia, in between that of thalassaemia minor and major, afflicts the patient This is termed thalassaemia intermedia Southeast Asia lies in the malaria belt w...

Ngày tải lên: 12/09/2015, 08:18

... 12(4):314-325 114 Higashimoto Y, Yamagata Y, Taya S, Iwata T, Okada M, Ishiguchi T, Sato H, Itoh H: Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences ... molecular fingerprint is analysed, would increase the accuracy of disease diagnosis, aid earlier disease detection, allow for improved clarification of disease subtypes an...

Ngày tải lên: 12/08/2014, 14:20

... Wee Liang for helping me in the synthesis of the NDA-AD cross-linker, Derek for helping me in the synthesis of the dialdehyde and Liquian and Hongyan for their help in the peptide synthesis - ... expression levels of the proteins, relatively newer approaches such as Activity- Based Protein Profiling (ABPP) provide more insights into the functional states of...

Ngày tải lên: 11/09/2015, 09:58

... transduction pathways in eukaryotes 1.4 Small Molecule Chemical Biology Tools for Studying Cellular Phosphorylation Events in vivo 1.4.1 Small- Molecule Mimetics of Phosphorylated Amino Acids The elucidation ... Molecule Chemical Biology Tools for Studying Cellular Phosphorylation Events In vivo 1.4.1 Small- Molecule Mimetics of Phosphoryl...

Ngày tải lên: 04/10/2015, 15:45

... the process Douglas Ray asked whether biobased approaches are going to scale Emptage said that scaling in fermentation is straightforward, and that tanks can be scaled almost as large as sugar ... for Energy: A Workshop Summary to the Chemical Sciences Roundtable http://www.nap.edu/catalog/12068.html 32 BIOINSPIRED CHEMISTRY FOR ENERGY • Cargill and Ashland are...

Ngày tải lên: 19/02/2014, 09:20

Ngày tải lên: 21/02/2014, 05:20

... information, the protein ligand interaction can be probed by [15N]-HSQC FEBS Journal 273 (2006) 4154 – 4159 ª 2006 The Authors Journal compilation ª 2006 FEBS 4157 15 N-labelled proteins by cell-free ... accelerated studies of proteins by NMR spectroscopy by assigning residue type information to every amide cross-peak observed in [15N]-HSQC spectra We anticipate that...

Ngày tải lên: 07/03/2014, 12:20

... a great demand for bioinformatics to provide a statistically valid interpretation of compound lists produced experimentally Currently, several bioinformatics approaches are available for metabolomics ... propose an analytical framework for the interpretation of molecular mechanisms that unite a list of compounds This analytical framework is implemented as the freel...

Ngày tải lên: 16/03/2014, 01:20

... overall Kappa for the four topics were 0.59 for pulmonary fibrosis, 0.79 for cholangiocarcinoma, 0.79 for diabetes mellitus and 0.59 for congestive heart failure We ran a set of queries for each of ... This is particularly important for using this system in recruiting patients for epidemiological research for disease incidence or disease prevalence studies and clinical t...

Ngày tải lên: 31/03/2014, 03:20