Mechanistic investigations on drug delivery from alginate matrices
Mechanistic investigations on drug delivery from alginate matrices
... alginates in drug delivery systems A6 Challenges of using alginate matrix tablets as drug delivery systems B Controlled drug delivery from polymeric matrices 10 B1 Significance of controlled drug delivery ... penetration front 88 A2.1 Matrix swelling 88 A2.2 Solvent penetration front 91 A2.3 Crack development in alginate matrices 99 B Impact of hydration behavior on...
Ngày tải lên: 14/09/2015, 12:26
Study on drug delivery for paclitaxel of the lactobacillus strains
... Study on Drug Delivery for Paclitaxel of the Lactobacillus Strains By DOAN THI THANH VINH ABSTRACT The practice of developing molecularly targeted drugs to achieve a higher degree of cancer therapy ... Rst is the retention time of standard The acceptable range for the variation of retention time was less than 5% 3.2.8 Calculation of the number of d...
Ngày tải lên: 23/10/2015, 15:38
SELF ASSEMBLY AND DRUG DELIVERY IN AMPHIPHILIC PEPTIDES MICROSCOPIC INSIGHTS FROM COARSE GRAINED SIMULATIONS
... microscopic insights into the self- assembly of amphiphilic peptides, and the loading and release of drug are provided Equilibrium and dynamic properties are obtained from a molecular level Key governing ... amphiphilic peptides from a microscopic scale, elucidate the detailed process of drug loading and release, and provide bottom-up guidelines towards the i...
Ngày tải lên: 09/09/2015, 08:13
Development of controlled drug delivery systems using uniform nanoporous materials as matrices
... tolerance of a variety of manufacturing methods Polymeric drug delivery systems under wide investigations are classified according to the mechanism controlling the release of the drug Some of the basic ... give benefits to drug companies by creating new forms of established drugs and offering improved versions of drugs It has been shown that companies developing new dru...
Ngày tải lên: 13/09/2015, 19:46
Controlled release alginate based microparticulate systems for drug delivery and chemoembolization
... reduced drug loss and possible controlled drug release It is widely known that poly (lactic-co-glycolic) acid (PLGA) is able to sustain drug release for a prolonged period of time and is therefore ... time -controlled and/ or target -controlled 22 INTRODUCTION delivery of drug In time -controlled delivery, the drug is released in a pre-determined rate while in tar...
Ngày tải lên: 13/09/2015, 20:39
Investigation on factors affecting drug delivery using polymers and phospholipids 1
... Conclusion and direction for future work REFERENCES LIST OF PUBLICATIONS 12 5 12 5 12 5 12 6 12 6 12 6 12 6 12 8 12 8 13 1 13 4 13 6 14 2 16 7 v SUMMARY Topical drug delivery helps to achieve therapeutic concentrations ... Materials and Methods 8.2 .1 Materials 8.2.2 Preparation of Diclofenac Sodium-Loaded Vesicles 90 90 91 91 91 92 92 93 93 93 94 94 94 95 98 10 0...
Ngày tải lên: 14/09/2015, 14:03
Investigation on factors affecting drug delivery using polymers and phospholipids 2
... (mg) L (mg) B (ml) IPA (ml) Appearance 25 25 25 25 25 25 25 22 5 22 5 22 5 22 5 22 5 22 5 22 5 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0. 625 0. 625 0. 625 0. 625 0. 625 0. 625 0. 625 Translucent oil Clear oil Opaque amber ... 26 .096 105 .29 5 EI 1.7 32 1.184 2. 006 2. 547 2. 213 1.176 2. 79 45 2. 4 Conclusion Proniosomal formulations with non-ionic surfactant were studied The effec...
Ngày tải lên: 14/09/2015, 14:03
Investigation on factors affecting drug delivery using polymers and phospholipids 3
... CD solutions (n =3) 3. 3 .3 Surface Tension and Contact Angle Measurments The surface tensions of aqueous solutions of different concentrations of RM β-CD and HP β-CD are shown in Fig 3. 3 A remarkable ... (3- 1) Where Kpunion and Kpion are the dependent drug permeabilities and Cunion and Cion are the dependent concentrations of ionized and unionized moieties, respectively (H...
Ngày tải lên: 14/09/2015, 14:03
Investigation on factors affecting drug delivery using polymers and phospholipids 4
... formulations contain mg/ml of T4 6.2 .4 FTIR Studies of Nanofibers Interaction between polymers and their functional groups were studied using FTIR Spectra of the fibers were obtained using the ... 97% of its drug content whereas formulation A released only 65% of its total drug content The release of T4 from the mixed polymer mat was found to be a function of PNIPAM concentratio...
Ngày tải lên: 14/09/2015, 14:03
Investigation on factors affecting drug delivery using polymers and phospholipids 5
... of drug encapsulated in all formulations (p > 0. 05) Proniosomes and conventional liposomes entrapped the most drug of 63.43 ± 9.31% and 67. 15 ± 5. 84%, respectively (p> 0. 05) The preparation methods ... ) 250 Transferosome Ethosome Niosome 200 PEG-PPG-PEG niosome Conventional liposome Proniosome Cerosome 150 100 Control 50 0 10 15 20 25 30 35 40 45 Time (h) Fig 8.3 Cumulativ...
Ngày tải lên: 14/09/2015, 14:03
UV CURABLE PRESSURE SENSITIVE ADHESIVE TRANSDERMAL DRUG DELIVERY PATCH BASED ON PVP PEGDA PEG COPOLYMERIZATION
... Spectroscopy Pure PEGDA macromer, and PVP, PEG and PG macromers and hydrogels of PEGDA, PVP- PEG, PVP- PEGDA, PVP- PEGDA- PEG and PVP- PEGDA- PEG- PG were analyzed by ATR-FTIR to investigate the interactions between ... UV- curable Pressure Sensitive Adhesive Transdermal Drug Delivery Patch Based on PVP- PEGDA- PEG Copolymerization Sara Faraji Dana...
Ngày tải lên: 02/10/2015, 17:14
INFLUENCE OF NITROGEN, ACETATE AND PROPIONATE ON HYDROGEN PRODUCTION FROM PINEAPPLE WASTE EXTRACT BY Rhodospirillum rubrum
... initial propionate concentrations on hydrogen production from pineapple waste extract by R rubrum was investigated Results showed that nitrogen levels and initial concentrations of propionate significantly ... mM) and initial concentrations of acetate on hydrogen production by R rubrum under continuous illumination Symbols: Acetate ( ), propionate...
Ngày tải lên: 05/09/2013, 09:08
Effect of Nitrate on Phosphorus Mobilization from Bottom Sediment in Shallow Eutrophic Lakes
... an increase in the inflow of domestic and industrial wastewater associated with the increase in urbanization and industrialization in these watersheds, resulting in increased eutrophication in ... and phosphorus mobilization To examine the contribution of nitrate to DIP release from sediments, incubation of sediment water core samples with nitrate were carried out u...
Ngày tải lên: 05/09/2013, 09:38
Effect of Calcium and Magnesium Addition on Arsenic Leaching from Paddy Field Soil of Bangladesh
... investigate the effect of Ca and Mg addition on the leaching behavior of As from highly contaminated paddy field soil under different concentrations of Ca and Mg addition, pH conditions and anaerobic ... Other Conditions 0.9 Effect of P and 100 and 2.0 pH adjusted to 3.0, 5.0, 7.0, 9.0 and 11.0 pH 7.0 Leaching in anaerobic incubation and 100 0.9 Eff...
Ngày tải lên: 05/09/2013, 10:15
Drug Delivery Systems
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery...
Ngày tải lên: 25/10/2013, 08:20