Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...

Ngày tải lên: 14/09/2015, 08:42

... coccidioidomycosis with caspofungin and fluconazole BMC Infect Dis 2006, 6:26 doi:10.1186/cc9228 Cite this article as: Zhang M, et al.: Invasive pulmonary and central nervous system aspergillosis following ... Kontoyiannis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik JA, Wingard JR, Patterson TF; Infectious Diseases Society of America: Treatment of...

Ngày tải lên: 13/08/2014, 21:21

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein na...

Ngày tải lên: 23/03/2014, 03:20

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... infection and neoplasms Neuralgic pain is generally expressed in the facial area as idiopathic trigeminal neuralgia The ill-defined category of atypical oral and facial pain includes a variety of pain ... hyperalgesia, and in the area of normal tissue surrounding the injury site, as secondary hyperalgesia (c) Phase (Neuropathic Pain) These are abnormal pain states...

Ngày tải lên: 05/10/2015, 13:53

... independent of gender, age and energy intake The design of our study (Table 1) provided the opportunity to establish whether each region of the CNS exhibits a unique pattern of gene expression Gene expression ... analysis of the effects of aging, CR and gender on gene expression in tissues throughout the body Here we report the results of the CNS comp...

Ngày tải lên: 14/08/2014, 08:20

... Theiler's 3murine encephalomyelitis virus elements in the central nervous system of SJL/J and C57BL/6 mice after infection with Expression of Toll-like receptors for viral Expression of Toll-like receptors ... multiple TLRs in the mouse brain and in TMEV-infected microglia[3,4] This could support the direct or indirect (by the induction of cytokines and chemokines...

Ngày tải lên: 12/08/2014, 04:21

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... were obtained from a rat brain atlas by Paxinos and Watson The injection was made at a rate of μl/ using a 10 μl Hamilton syringe with a 26-gauge needle At the end of each injection, the syringe ... Contralateral rotation measurements following administration of apomorphine in each experimental group are shown in bar graph at days and 21 days post-6-OHDA injection Data...

Ngày tải lên: 19/06/2014, 22:20

... regenerated, hyaline cartilage or fibrocartilage? Non-invasive ultrasonic evaluation of tissueengineered cartilage Rheumatology 2004, 43:1106-1108 Laasanen MS, Töyräs J, Vasara A, Saarakkala S, Hyttinen ... were averaged for each cartilage measurement Previously, we determined the standard L*, a* and b* values and the standard spectral reflectance ratio of intact articular ca...

Ngày tải lên: 09/08/2014, 10:21

... normal repaired cartilage tissue; D2, D4, and D5 show nearly normal results; and D3 showed abnormal repair, with 50% filling of repaired cartilage and approximately half of the repaired cartilage ... participated in operative anesthesia and preoperative and postoperative animal care JS and NP participated in pathological and radiological interpretation SL particip...

Ngày tải lên: 09/08/2014, 14:21

... frequently employ autoantigen microarrays as a screening tool to identify autoantibody reactivities using a multiplex platform and rely heavily on statistical algorithms to determine significant differences ... TLR inhibitors are already being tested in SLE in early-phase human clinical trials Our studies provide a crucial link between the IFN -I system and TLR signaling in...

Ngày tải lên: 09/08/2014, 14:22

... Critical Care February 2005 Vol No Van Putte et al high mortality rate for the patient Some causes of warm ischemia–reperfusion injury are cardiopulmonary bypass during cardiac surgery and pulmonary ... 30 to hours of reperfusion in a model of acute lung injury, which was defined by quantifying apoptosis and alveolar oedema R2 Materials and methods Animals Male inbred...

Ngày tải lên: 12/08/2014, 20:20

... microcirculation) and reduced leucocyte activation (a marker of inflammation) in experimental sepsis Key messages • Dopexamine improved intestinal microvascular blood flow in a sepsis model in rats • Dopexamine ... the aim being to maintain adequate oxygen delivery to all organs and to the gut in particular In addition to noradrenaline (norepinephr...

Ngày tải lên: 13/08/2014, 02:24