Design and synthesis of cysmethynil and analogues as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)
Design and synthesis of cysmethynil and analogues as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)
... Wang M, Casey PJ Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) v TABLE OF CONTENTS ACKNOWLEDGEMENT .ii CONFERENCES AND PUBLICATIONS ... Analogues of cysmethynil demonstrate improved isoprenylcysteine carboxyl methyltransferase (Icmt) inhibition activity and antiproliferative activity in PC3 prosta...
Báo cáo Y học: Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes pot
... kinase and mM MgCl2 or 0.05 UÆmL)1 of pyruvate kinase and mM MnCl2 PEP carboxylase activity was determined in a coupled assay with malate dehydrogenase, as described previously [30] The rate of ... transiently phosphorylated in the course of the catalytic cycle, for instance, the activesite histidines of enzyme I of the PTS [2], phosphoenolpyruvate synthase, and pyruvate...
Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
... ATGGCGCCATTTTTCTTGAGACATGCC-3¢; reverse, 5¢-CTGGGATCCGTCCGAATCAGGTTCCTTC-3¢ (purchased from Sigma), and the pKK plasmid as a template [32] The resulting fragment was cloned into NcoI and BamHI sites of the ... Suv3(D1-159) and WNV NTPase/helicases The NTPase/helicase domain of HCV NS3 was expressed in E coli and purified as described previously [30], with certain modi...
Báo cáo hóa học: " One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels" doc
... doi:10.1007/s11671-010-9774-z Cite this article as: Zhai et al.: One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels Nanoscale Res Lett 2011 ... temperature, and 19 mg of Se powder was added Finally, the mixture was heated to 240°C and kept for a certain period of time such as 1, 5, 60, and 120...
identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications
... ABSTRACT IDENTIFICATION, DESIGN AND SYNTHESIS OF OXYGENATED HYDROCARBON-BASED CO2-SOLUBLE POLYMERS FOR CHEMICAL AND PETROLEUM ENGINEERING APPLICATIONS Lei Hong, Ph.D University of Pittsburgh, 2006 ... defended on March 29, 2006 and approved by Dr Eric J Beckman, Professor, Chemical and Petroleum Engineering Department Dr J Karl Johnson, Professor, Chem...
Green synthesis of copper nanoparticles colloidal solutions and used as pink disease treatment drug for rubber tree
... average size of copper nanoparticles was about 6nm via TEM images This colloidal solution was used as anti Pink Disease drug for rubber tree at low concentration (dose of resistance fungus of about ... method This colloidal solution was used as anti Pink Disease drug for rubber tree at low concentration (dose of resistance fungus of about 5-7p...
Design and synthesis of stimuli responsive polymer based nanoparticles
... of stimuli- responsive polymers are temperature -responsive polymers and pH -responsive polymers Other types of stimuli- responsive polymers, such as light -responsive polymers, field -responsive polymers ... methodologies for synthesis of stimuli- responsive polymers and the techniques for preparation of smart polymer based nanoparticles In Chapter 3, well-de...
Design and synthesis of functional graphene composites and their applications
... DESIGN AND SYNTHESIS OF FUNCTIONAL GRAPHENE COMPOSITES AND THEIR APPLICATIONS JANARDHAN BALAPANURU M.Sc., University of Pune, India A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... bond of graphene and (b) formation of bond between organic functional groups and oxygenated-groups of GO (a) Addition of free radicals to sp2-carbon of grap...
Synthesis of metal oxide nanostructures and their applications as lithium ion battery anodes
... IONP@PC and IONP@mC-600 Insets of C and F: SAED patterns of IONP@PC and IONP@mC-600 95 Figure 6-4: Particle size distributions of (A) IONP@PC and (B) IONP@mC-600 96 Figure 6-5 TEM images of IONP@mC-600 ... iron oxides and lithium was in the 1980s.[51] However, the nature of the reaction was not clear until J M Tarascon and his coworkers reported the conversion reaction...
Design and synthesis of donor acceptor hybridized small molecules and graphene derivatives for photovoltaic and optical studies
... DESIGN AND SYNTHESIS OF DONOR ACCEPTOR HYBRIDIZED SMALL MOLECULES AND GRAPHENE DERIVATIVES FOR PHOTOVOLTAIC AND OPTICAL STUDIES ANUPAM MIDYA M.Sc (Chemistry), ... the interface of the donor and acceptor material and split into hole and electron For efficient charge separation, the HOMO and LUMO energy levels of p-type (Donor) and n-type (A...
Synthesis of crown ether and cyclam capped beta cyclodextrin bonded silica particles and their application as chiral stationary phases in liquid chromatography
... the Synthesis of Bonded Chiral Stationary Phases for Liquid Chromatography 1.3.1 Types of Chiral Stationary Phases for Liquid Chromatography 1.3.2 Preparation of β -Cyclodextrin Type of Chiral Stationary ... with Crown Ether- capped β-CD -bonded Phases and Cyclam- capped β-CDbonded Phases 124 5.4 Concluding Remarks 128 5.5 References 129 CHA...
Design and synthesis of novel metal complex protein conjugation agents for applications in bio imaging
... Design and Synthesis of novel metal complex- protein conjugation agents for Applications in bio- imaging WANG TAO (BSc, Sichuan University2008 ) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... Modification of Proteins There is an increasing interest in protein conjugates for diagnosis and therapy Even though proteins often display limited pharmac...
The Design and Implementation of a Log-Structured File System
... purpose The separate data area of these database systems means that they not need the segment cleaning mechanisms of the Sprite LFS to reclaim log space The space occupied by the log in a database system ... log as the most up to date ‘‘truth’’ about the state of the data on disk The main difference is that database systems not use the log as the final repositor...
Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... orally [27] Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 as a potential therapeutic ... O-glucosides involved in the biosynthesis of chrysomelidial and salicin These substances are synthesized and secreted as part of a defense mechanism used by la...
Design and development of major balance of plant components in solid oxide fuel cell system
... determining the SOFC system performance The detailed designs of each of these components in the INER SOFC system are described in the following subsections 3.1 Flow distributor In general, an SOFC ... 44%) Design of SOFC BOP components The BOP components of a SOFC system account for between 50% and 70% of the total system cost Due to the high operating temper...
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