Dual functions of caspase 4 in apoptosis and inflammation

... suggesting that caspase- 11 is upstream of caspase- 1 and unlike caspase- 1, caspase- 11 is LPS-inducible 14 1.2 .4. 3 Caspase- 1 and Caspase- 5 Caspase- 1 is the prototype for the group of inflammatory caspases ... DN caspase- 12? Another glaring shortcoming is the lack of re-expression of caspase- 4 in the cell line lacking caspase- 4 The figures and in the...

Ngày tải lên: 13/09/2015, 19:50

... intrinsic pathway (mitochondrial) via the apoptosome [1, 17-23] Figure Extrinsic and intrinsic pathways to caspase- 3 activation Overview of pathways to caspase- 3 activation Each separate gray ... cell death for either pathway is executed through a cascade activation of effector caspases (e.g., caspase- 3) by initiator caspases (e.g., caspase- 8 and -9) and the amplific...

Ngày tải lên: 13/08/2014, 16:21

... of c-Jun, c-Fos and ATF2 29 1. 3 .1. 3 Regulation of AP- 1 activity by its interacting proteins 30 1. 3.2 Role of AP- 1 in cell proliferation and differentiation 31 1.3.2 .1 Role of AP- 1 in ... AP- 1 in cell proliferation 31 1.3.2 .1. 1 AP- 1 is an important regulator in cell proliferation 31 1.3.2 .1. 2 Mechanisms of AP- 1 modulation of...

Ngày tải lên: 16/09/2015, 15:54

... (19 88) The cellbinding domains of plasminogen and their function in plasma J Biol Chem 263, 11 928 11 9 34 24 Thewes T, Constantine K, Byeon IJ & Llinas M (19 90) Ligand interactions with the kringle ... rate of plasmin formation in the absence of mAbs Plasmin-induced cell detachment and apoptosis are impaired by selectively blocking the LBS of plasminogen K1 o...

Ngày tải lên: 20/02/2014, 01:20

... between survivin and cleaved caspase-3 expression Additionally, our finding that the mRNAs of caspase-3, xIAP and survivin were generally higher in active RA compared with inactive RA synovial ... related apoptosis inducing ligand; TUNEL = terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling; xIAP = x-linked inhibitor of apoptosis protein levels...

Ngày tải lên: 09/08/2014, 01:22

... this article as: Balart et al.: The use of caspase inhibitors in pulsedfield gel electrophoresis may improve the estimation of radiationinduced DNA repair and apoptosis Radiation Oncology 2011 ... AJ, Konings AW, Kampinga HH: Feasibility of measuring radiation-induced DNA double strand breaks and their repair by pulsed field gel electrophoresis i...

Ngày tải lên: 09/08/2014, 09:20

... setting of more routine decompensated heart failure, and the effect milrinone in ischemic subset of patients deserves further investigation Conclusion Initiation of milrinone therapy in patients ... change in TnI or MYO after 24 hours of milrinone compared to baseline On the other hand, there were significant reductions in inflammatory and apoptotic signaling...

Ngày tải lên: 18/06/2014, 15:20

... repeats (ANK), a transactivation domain (TAD) and a PEST domain (P) TM, transmembrane domain (b,c) Two models for the roles of Ofut1 in Notch trafficking Each model is illustrated in a schematic ... (green) adapted from [19] The S2 cleavage site is indicated by an arrow The intracellular domain (NICD) contains various elements involved in transcriptional activation:...

Ngày tải lên: 06/08/2014, 18:21

... exports and textile industries, earning the proceeds 54 The Rise and Fall of Abacus Banking in Japan and China for the imports of much-needed capital goods In addition, her victory in the Sino-Japanese ... expansion of Japanese banks in the late 1970s and the 1980s, which will be addressed in the next chapter 48 The Rise and Fall of...

Ngày tải lên: 06/08/2014, 20:22

... alter the level of Bcl-2 in rabbit osteoclasts but caused a marked increase in the level of Mcl-1, an anti-apoptotic member of the Bcl-2 family that is expressed in cells of the myeloid lineage ... prevent inhibition of and increases Mcl-1 RANKL prevents activation of caspase-9protein prenylation in osteoclasts but does not prevent inhibition of pr...

Ngày tải lên: 09/08/2014, 14:20

... acid 18:4n-3 Elongase 20:3n-6 Dihomo-γ-Linoleic acid 20:4n-3 -5 -Desaturase 20:4n-6 Arachidonic acid 20:5n-3 Eicosapentanoic acid Elongase 22:4n-6 Adrenic acid 22:5n-3 -4 -Desaturase 22:5n-6 An ... (20 04) A pooled analysis of placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder Journal of Clinical Psychiatry, 65(3), 43 2 44 1 Isoj...

Ngày tải lên: 11/08/2014, 04:20

... mechanism involving COX2 and PGE2 expression in the resolution of inflammation Page of 11 Proinflammatory cytokines, including IL-17 and TNF-a, play a critical role in the progression of synovitis and ... STderived inflammatory cells in the presence of indomethacin Rheumatoid ST contains a number of proinflammatory cytokines that influence osteoclast formation and...

Ngày tải lên: 12/08/2014, 15:22

... Sputum Craniotomy Pneumonia/COPD Respiratory P aeruginosa Sputum Aortic-femoral bypass Pneumonia/Perforated ulcer Abdominal Candida albicans Ascites Laparatomy Cholangitis/UTI Abdominal/Urinary Enterococcus ... Subarachnoid hemorrhage Intracerebral hemorrhage Anaphylaxis (anaesthesia) Guillain-Barre syndrome Intracerebral hemorrhage 10 Anaphylaxis (anaesthesia) 11 Epilepsy ARDS, acute re...

Ngày tải lên: 13/08/2014, 03:20

... cytotoxicity of the bacteria in biofilms is one of the adaptations that allows them to persist Previous studies indicate that deletion of the gene encoding the protein MgtE from P aeruginosa increases the ... inextricably linked A key finding of this study is that disruption of one function of MgtE does not always eliminate the other In interpreting the r...

Ngày tải lên: 24/08/2014, 11:35

... treated CEM /Bcl- 2 cells Indeed, if MnSOD was engaged in blunting mitochondrial O2- increase in antimycin-treated CEM /Bcl- 2 cells due to increased activity in the context of Bcl- 2 overexpression, ... a conformational change in Bcl- 2, exposing its BH3 domain, converting Bcl- 2 from anti-apoptotic to pro-apoptotic (Lin, Kolluri et al 20 04) 1.6 Non-canonical...

Ngày tải lên: 14/09/2015, 08:42