Cytomegalovirus infections in solid organ transplant recipients

... 2003) 15 Cytomegalovirus infections in solid organ transplant recipients 1.3 Clinical findings associated with human cytomegalovirus infections 1.3.1 Infections in immunocompetent hosts CMV infection ... disease most common 19 Cytomegalovirus infections in solid organ transplant recipients 1.3.2.1 Cytomegalovirus infections in transplant patients Al...

Ngày tải lên: 13/09/2015, 19:41

... doi:10.1186/gm253 Cite this article as: Roedder S, et al.: Biomarkers in solid organ transplantation: establishing personalized transplantation medicine Genome Medicine 2011, 3:37 ... monitoring have decreased the incidence of AR in solid organ transplantation However, the lack of noninvasive biomarkers makes early diagnosis and optimized treatment regimens difficul...

Ngày tải lên: 11/08/2014, 12:21

... Madhavan et al.: “pp65 antigenemia and real time polymerase chain reaction (PCR) based-study to determine the prevalence of human cytomegalovirus (HCMV) in kidney donors and recipients with follow-up ... reported among asymptomatic and symptomatic patients respectively [11] The utility of the real time PCR technique for HCMV...

Ngày tải lên: 12/08/2014, 02:20

... transplants T gondii usually causes disease in the brain In hematopoietic stem cell transplant recipients, acute pulmonary disease may also occur Heart transplant recipients develop disease in ... columns and monoclonal-antibody depletion procedures results in a higher incidence of contamination In one series of patients receiving contaminated products, 14% had fever or bacte...

Ngày tải lên: 07/07/2014, 15:20

... mature in an old host who has several latent infections already Nevertheless, most infections occur in a predictable time frame after transplantation (Table 126 -2) Table 126-2 Common Sources of Infections ... to infection The reconstitution that follows transplantation has been likened to maturation of the immune system in neonates The analogy does not entirely predict infectio...

Ngày tải lên: 07/07/2014, 15:20

... ulcerations occur in both the lower and the upper gastrointestinal tract, and it may be difficult to distinguish diarrhea due to GVHD from that due to CMV infection The finding of CMV in the liver ... abnormalities It is interesting that the ocular and neurologic manifestations of CMV infections are uncommon in these patients Management of CMV disease in HSCT recipients includes s...

Ngày tải lên: 07/07/2014, 15:20

... combat disease Treatment of CMV pneumonia in HSCT recipients (unlike that in other clinical settings) involves both IV immune globulin (IVIg) and ganciclovir In patients who cannot tolerate ganciclovir, ... infection of B cells leads to several interesting phenomena in HSCT recipients The marrow ablation that occurs as part of the HSCT procedure may sometimes eliminate latent EBV...

Ngày tải lên: 07/07/2014, 15:20

... Aerosolized ribavirin is difficult to administer Antibody in particular may prove more active in immunocompromised hosts, but relevant evaluation is lacking Influenza also occurs in HSCT recipients and ... of influenza Amantadine and rimantadine have limited effects, primarily reducing symptoms and shortening the duration of illness caused by sensitive strains of influenza A virus The...

Ngày tải lên: 07/07/2014, 15:20

... glomerulopathy in kidney transplant recipients, bronchiolitis obliterans in lung transplant recipients, vasculopathy in heart transplant recipients, and the vanishing bile duct syndrome in liver transplant ... acute infections in recipients of SOT are different from those that infect HSCT recipients because SOT recipients not go through a period of neutropenia As...

Ngày tải lên: 07/07/2014, 15:20

... transplantation decreases the incidence of early and middle-period infections (see below, Table 126-4, and Table 126-5) Table 126-5 Prophylaxis of Infections in Transplant Recipients Risk Organism ... cephalosporins to decrease the risk of postoperative complications Urinary tract infections developing soon after transplantation are usually related to anatomic alterations resulti...

Ngày tải lên: 07/07/2014, 15:20

... predisposing to bacterial infection VZV may cause fatal disseminated infection in nonimmune kidney transplant recipients, but in immune patients reactivation zoster usually does not disseminate ... for transplant recipients Additional oral prophylactic agents, such as maribavir, are in clinical study Infection with the other herpes-group viruses may become evident within months a...

Ngày tải lên: 07/07/2014, 15:20

... blastomycosis may cause pulmonary infiltrates or disseminated disease Late Infections Late infections (>6 months after kidney transplantation) may involve the CNS and include CMV retinitis as well as other ... (see "Middle-Period Infections, " above) Heart Transplantation Early Infections Sternal wound infection and mediastinitis are early complications of heart transplantation An indo...

Ngày tải lên: 07/07/2014, 15:20

... particularly in patients maintained on intense immunosuppressive therapy A subset of heart and heart-lung transplant recipients may develop early fulminant EBV-LPD (within months) Treatment includes ... scenario is increasingly common, particularly in patients with ongoing GVHD Late Infections EBV infection usually presents as a lymphoma-like proliferation of B cells late after hear...

Ngày tải lên: 07/07/2014, 15:20

... rapid intervention may therefore become necessary The approach to EBV-LPD is similar to that described in other sections Liver Transplantation Early Infections As in other transplantation settings, ... Treatment includes antibiotic administration and drainage as necessary Liver transplant patients have a high incidence of fungal infections, and the occurrence of fungal (often candida...

Ngày tải lên: 07/07/2014, 15:20

... bacterial and yeast infections Most pancreatic transplants are drained into the bowel, whereas the remaining transplants (~20%) are drained into the bladder A cuff of duodenum is used in the anastomosis ... of CMV infection, EBV-LPD, and infections with opportunistic pathogens in patients receiving a pancreatic transplant are similar to those in other SOT recipients Miscellaneou...

Ngày tải lên: 07/07/2014, 15:20