... airway inflammatory diseases Therapeutic targeting of LPA2 may be beneficial in reducing allergic inflammatory responses in airway diseases Competing interests The authors declare that they have ... 279(39):41085-41094 Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, Momose K: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid- induced airway hyperresponsiveness in guinea pigs ... mediators including lipid mediators play a critical role in the pathogenesis of chronic airway diseases and facilitate the recruitment, activation, and trafficking of inflammatory cells in the airways...