Nhp6p and med3p regulate gene expression by controlling the local subunit composition of RNA polymerase II

... clearance of RNA Pol II that contained Rpb4p Therefore, Nhp6p and Med3p repressed transcription of ZDS1 by controlling the local subunit composition of RNA Pol II On the other hand, Nhp6p generally ... in RNA splicing RNA polymerase III is needed for the synthesis of transfer RNA (tRNA) and other small nuclear RNAs (including the small 5S rR...

Ngày tải lên: 11/09/2015, 16:08

... that indicates the likelihood of the genes in a network being found together due to chance A score of indicates a in 100 chance that the focus genes of interest were linked in the network by chance ... Illustrations of the top gene networks at the day time point of the time-dependent microarray analysis Figure Illustrations of the top gene networks at th...

Ngày tải lên: 12/08/2014, 14:20

... Therefore, we tested the effect of the replicative state of the cell on the interaction between Pol e and RNA pol II A possible confinement of the interaction to late G1 and S phases (the cell ... pol II H5 (red) and a-Pol e G1A (green) Yellow indicates colocalization in the merge image Cells were permeabilized in hypotonic buffer in the presence of deter...

Ngày tải lên: 07/03/2014, 11:20

... II complex S2 Serine of yeast RNA polymerase II C-terminal domain S2-P Phosphorylated serine of yeast RNA polymerase II C-terminal domain S5 Serine of yeast RNA polymerase II C-terminal domain ... study the RNAPII modifications on both the CTD and the globular core of the enzyme in the presence and absence of Rtr1 IV Mechanisms for RNAPII de...

Ngày tải lên: 24/08/2014, 09:44

... activation was Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation ... leading to the uPA gene However, the nature of these signaling events has remained largely unknown Because both disruption of E-cadherin- depen...

Ngày tải lên: 19/02/2014, 05:20

... MEK -ERK1/2 pathway played dual roles in cumulus cells One role is the induction of EGF-like factor and TACE /ADAM17 expression The other is direct induction of cumulus expansion of porcine COCs In ... expression of EGF-like factor and TACE /ADAM17 in cumulus cells was induced by a PKA-, p38 MAPK- and ERK1/2- dependent mechanism du...

Ngày tải lên: 20/06/2014, 07:20

... 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Proinflammatory Cytokines Gene Expression by Mice Spleen Cells 253 by mouse spleen cells Here, we demonstrate that phenol downregulates IL-1, IL-6 and TNFα gene expression, and that ... of Benzo[a]pyrene, 2-Bromopropane, Phenol and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Proinflammatory Cytokines Gene Ex...

Ngày tải lên: 07/08/2014, 15:20

... ces 003 rof C 27 ta noisnetxe lanif dna ces 09 rof C 27 pmet noisnetxe ,ces 54 rof C 06 pmet gnilaenna ,ces 54 rof C 49 ta noitarutaned ,ces 06 rof C 49 ta noitarutaned laitini ,sgniwollof eht ... stibihni dica ciadiakO ]9[ )Mµ 001( niloksrofyxoedid ,1 dna )Mµ 001( niloksrof ,)Mµ 004( BP htiw srh 61 rof sllec amotapeh nekcihc gnitaert retfa dnuof osla saw 73A3PYC fo slevel tpircsnart fo ... s...

Ngày tải lên: 07/08/2014, 18:21

... aggrecan and type II collagen mRNA by TNF-α, by EGF or R132 tumor necrosis factor alpha (TNF-α) Epidermal growth factor (EGF) does not alter NF-κB activation by tumor necrosis factor alpha (TNF-α) ... necrosis factor alpha Inhibitionandprotein collagen mRNAnot prevent reduction in levels of aggrecan or type II collagen mRNA by tumor necrosis factor alpha...

Ngày tải lên: 09/08/2014, 06:22

... replication by drugs that block eIF5A modification Inhibition of HIV replication by drugs that block eIF5A modification A Hypusination of eIF5A (gray) occurs in two steps: the transfer, catalyzed by DHS, ... DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, cat...

Ngày tải lên: 12/08/2014, 23:22

... meaning and relevance to the cell cycle It is of interest to look at the basic data in Table of Liu, Gaido and Wolfinger [1] In Table they present results on the gene expression amplitudes in two ... experiment Summary The work of Liu, Gaido and Wolfinger [1] is a statistical analysis of a well-regarded paper [2] on the pattern of g...

Ngày tải lên: 13/08/2014, 23:20

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN -REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... signaling 21 1.3.4 Regulation of estrogen receptors 23 1. 3.5 Estrogen and estrogen receptors in human breast cancer 27 v 1. 4 THE SODIUM HYDROGEN EXC...

Ngày tải lên: 10/09/2015, 15:49

... C/EBP factors in the inhibiting effect of amino acids on gene expression Concerning the stimulation of gene expression by the presence of amino acids, only one gene, Pept 1, encoding a peptide transporter, ... presence of amino acid(s) resulted in inhibition of the DNA binding of the involved transcription factors By contrast, the presence of amino acid ma...

Ngày tải lên: 07/03/2014, 00:20

... (20 04) Unanticipated antigens: translation initiation at CUG with leucine PLoS Biol 2, e366 15 Kozak M (1986) Point mutations dene a sequence anking the AUG initiator codon that modulates translation ... an N-terminal leucine amino acid Our present study indicates that nonAUG translation initiation may be operable more often than anticipated This may have a grea...

Ngày tải lên: 07/03/2014, 10:20

... and dbcAMP upregulated the syndecan-1 and syndecan-4 mRNA expression in 30-days-old rat Sertoli cells (Tables and 3) Indeed, FSH increased syndecan-1 and syndecan-4 mRNAs expression by +40 and ... effects of increased intracellular cAMP and intracellular calcium levels Moreover, calcium induces no effect on glypican-1 and syndecan-1 mRNAs express...

Ngày tải lên: 17/03/2014, 23:20