Functions of deleted in liver cancer (DLC1) in cell dynamics

... novel binding properties of some SAM domains, showing that roles of SAM domains are not restricted in mediating protein-protein interactions One surprising finding is that the SAM domains of translational ... called as “Arginine finger” In 11 RhoGAP-stimulating GTP hydrolysis, the long side chain of this arginine residue allows it to “dip” like a finger into the GTP-binding pocket...

Ngày tải lên: 11/09/2015, 16:06

... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... proteins, including CDC42, Par6 and aPKC, did not seem to be involved in the ERp29- induced epithelial morphogenesis These findings demonstrated a novel function and...

Ngày tải lên: 13/10/2015, 15:55

... associated with induced expression of insulin-like growth factor binding protein-2 in the uterus and ovary and decreased expression of insulinlike growth factor binding protein-3 in the uterus These changes ... as DFMO retards the growth of the pancreas [101], but does not inhibit the secretory function of the exocrine part of the organ [102] The cellular func...

Ngày tải lên: 30/03/2014, 13:20

... to further confirm and extend the role of neutrophils in driving lymphangiogenesis in a disease model of inflammation We choose to examine this in a chronic skin inflammation, in a model of cutaneous ... was mainly confined to the subcapsular region of the LN The heparin-binding carboxyl-domain of the predominant VEGF-A isoform, VEGF164 may bound the molec...

Ngày tải lên: 09/09/2015, 18:48

... trafficking……………………………………… 11 1. 3.3.2 Lymphatics and inflammation resolution …………………………………… 13 1. 3.3.3 Lymphatics and immune tolerance…………………………………………… 15 1. 4 The biology of VEGFs and their receptors…………………………… 16 1. 4 .1 ... through the alternative splicing of exons and Exon encodes a heparin-binding domain, while exons and encode a NRP/ heparin-binding doma...

Ngày tải lên: 09/09/2015, 18:48

... multi-domain protein, consisting of N-terminal SAM domain, C-terminal START domain and the catalytic RhoGAP domain This allows for its interaction with diverse cellular proteins, including FAK, Tensins ... light chain phosphatase (MLCP) to inactivate it and hence ensuring phosphorylation of myosin by myosin light chain kinase (MLCK) This leads to actin-myosin cross-linking, trig...

Ngày tải lên: 10/09/2015, 09:29

... Real-time imaging and analysis of differences in cadmium dynamics in rice cultivars (Oryza sativa) using positron-emitting 107Cd tracer Satoru Ishikawa1*§, Nobuo ... to grains in typical rice cultivars that differed in grain Cd concentrations We used positron-emitting 107Cd tracer and an innovative imaging technique, the positron-emitting tr...

Ngày tải lên: 11/08/2014, 11:21

... only around 50% If the number of time points in exp2 One often neglected but important factor in interpreting and analyzing cell cycle related gene expression data is the quality of synchrony of ... cycle related genes In a single cell, the amplitude and phase of a cell cycle related gene are considered two independent parameters in a sinusoidal model Within a...

Ngày tải lên: 13/08/2014, 23:20

... meaning and relevance to the cell cycle It is of interest to look at the basic data in Table of Liu, Gaido and Wolfinger [1] In Table they present results on the gene expression amplitudes in two ... experiment Summary The work of Liu, Gaido and Wolfinger [1] is a statistical analysis of a well-regarded paper [2] on the pattern of g...

Ngày tải lên: 13/08/2014, 23:20

... Role of STAT3 in cell migration under physiological conditions 25 1.10.2 Role of Stat3 in cell invasion and metastasis 27 1.10.3 Cytoplasmic role of Stat3 in regulating microtubules 28 1.11 Cell ... how Stat3 regulates cell migration In this study, we used Stat3- deficient and wild type Stat3- expressing murine embryonic fibroblasts as a model to inve...

Ngày tải lên: 11/09/2015, 16:06

... Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in cell cycle 69 5.3 Role of miR-193a in cell cycle 73 5.4 Roles of miR-122a, miR-96 and miR-107 in cell cycle 78 ... Over -expression of let-7 in cancer cell lines alters cell cycle progression and reduces cell division, and it has been shown that multiple ge...

Ngày tải lên: 05/10/2015, 22:31

... Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in cell cycle 69 5.3 Role of miR-193a in cell cycle 73 5.4 Roles of miR-122a, miR-96 and miR-107 in cell cycle 78 ... Over -expression of let-7 in cancer cell lines alters cell cycle progression and reduces cell division, and it has been shown that multiple ge...

Ngày tải lên: 06/10/2015, 20:35

... Evaluation of risk of liver metastasis in colorectal adenocarcinoma based on the combination of risk factors including CD10 expression: multivariate analysis of clinicopathological and immunohistochemical ... relationship between the density of TAMs and the potential of hepatic metastasis and survival, this study showed that a higher density of macrophages i...

Ngày tải lên: 18/06/2014, 16:20

... mechanism of liver cancer stem cells Conclusions This work provides an in vivo model for the study of mechanisms of neoplastic transformation of liver cancer stem cells by separately sorting SP ... differentiation of normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Theref...

Ngày tải lên: 10/08/2014, 10:20

... transgenic line Establishing the role of autophagy in liver cancer 4.1 Preliminary data implicating autophagy inhibition in liver cancer 4.2 Establishing double transgenic lines with liver- specific ... as a model organism in the study of human diseases including cancers, we aim to investigate the role of autophagy in liver cancer using our establish...

Ngày tải lên: 12/10/2015, 17:35