Substance p chemokine interaction in mouse pancreatic acinar cells, and its implications in acute pancreatitis

... RANTES and CXC chemokines, IL-8, GRO-α, CINC and MIP-2 are important in acute pancreatitis 1.5.1 Chemokines in Acute Pancreatitis A study of chemokine gene expression in rat pancreatic acinar cells ... is involved in substance P (SP)-induced MCP-1, MIP-1α and MIP-2 secretion 116 4.7 Substance P (SP)/NK1R interaction is involved in PKCδ and MEKK1 activation 118 5.1 Substance P (SP) induces phosphorylation ... preprotachykinin B (PPTB) and preprotachykinin C (PPTC) in mammals Substance P is a product of the PPTA gene (Harrison and Geppetti 2001; Severini, Improta et al 2002) and is localized in the central...

Apoptosis of the pancreatic acinar cells and acute pancreatitits

... microscopy, the cell injury exhibits (i) the presence of acinar- cell ghosts; (ii) vacuolization and swelling of acinar cells or (iii) the destruction of the histoarchitecture of the whole or parts of the ... xv SUMMARY The mechanisms of apoptosis in pancreatic acinar cells and the mechanisms by which induction of acinar cell apoptosis protects against acute pancreatitis were investigated The results ... form of cell death in acute pancreatitis However, little is known about the molecular mechanisms of pancreatic acinar cell death and how the induction of apoptosis in pancreatic acinar cells...

Báo cáo khoa học: Prohibitin is expressed in pancreatic b-cells and protects against oxidative and proapoptotic effects of ethanol pdf

... role in pancreatic b-cells The objective of the present study was to investigate the expression and antioxidant effects of PHB in pancreatic b-cells exposed to ethanol Effects of prohibitin in b-cells ... endocytosis and vesicle recycling [53] In summary, we found that PHB is expressed in pancreatic b-cells and increases with oxidative stress induced by ethanol exposure, possibly to protect b-cells against ... staining; (B) Mitoﬂuor Red 589 (mitochondria) staining; (C) anti-His (exogenous PHB)-FITC staining; (D) merge The arrows indicate staining of His-tagged PHB in (C) or both PHB and Mitoﬂuor in...

Báo cáo khoa học: "Categorial Fluidity in Chinese and its Implications for Part-of-speech Tagging" pptx

... verbalisation in Chinese was observed in Tai (1997) In other words, verbs are more freely deverbalised than nouns denominalised This fluidity between verbal and nominal status of verbs can in theory ... nouns, and the implications this phenomenon might have for POS tagging References Chinese Knowledge Information Processing Group (CKIP) 1993 iirt,=,m,3 }K (EN) Technical Report no.9305, Academia Sinica, ... LIVAC, A Chinese Synchronous Corpus, and Some Applications In Proceedings of the ICCLC International Conference on Chinese Language Computing, Chicago, pages 233-238 Xia, F 2000 The Part-Of-Speech...

Báo cáo Y học: Interaction of bovine coagulation factor X and its glutamic-acid-containing fragments with phospholipid membranes A surface plasmon resonance study pdf

... zymogen factor X, activated factor X (factor Xa) and the active site inhibited form DEGR -factor Xa as well as the the factor X peptides were studied with surface plasmon resonance The Ca2+ concentration ... ﬁlters Membrane binding experiments on factor X, factor Xa, DEGR -factor Xa and the Gla-containing fragments of factor X were performed with membranes containing either 25 mol% PtdSer and 75 mol% ... on rate This may be explained by assuming that only a small fraction of the fragment has a conformation that is commensurate with membrane-binding The on-rates for Gla–EGFN and Gla–EGFNC are about...

Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx

... from human T cells in vitro To study the role of C5a on human CD4 + T cells, we used ELISA and intracellular staining to detect cytokine expression PBMCs from AMD patients and controls were treated ... Intracytoplasmic staining of IL-22 and IL-17 from both controls and AMD patients after days of culture with or without C5a and C5aR antagonist Liu et al Journal of Translational Medicine 2011, 9:111 http://www.translational-medicine.com/content/9/1/111 ... representative data (C) TUNEL staining of CD4+ T cells treated with or without C5a and C5aR antagonist (D) PBMCs were treated with or without C5a for days T cells were sorted and processed for western...

Báo cáo y học: "New role for Agrin in T cells and its potential importance in immune system regulation" ppsx

... specializations in the brain, indicating that Agrin has a role, at least in part, in maintaining synaptic structure in this tissue [23] In addition, Agrin is expressed at high levels in the brain microvasculature, ... rafts are reviewed in [26]) and of the TCR [25] Interestingly, Agrin from activated T cells induced clustering of acetylcholine receptors when added to myotube cultures, indicating that certain ... of the Agrin gene; however, at present this is only an assumption and it remains to be seen whether Agrin plays a role in the INF system A working hypothesis on the function of Agrin in the immune...

Báo cáo khoa học: "The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival" ppt

... release of VEGF, and the expression and distribution of VEGF and its receptors in the lung during the early onset of ALI induced by intestinal ischemia-reperfusion (IIR), a well-established model of ... is that the increased VEGF is simply the reflection of increased protein leakage in the lung In clinical studies, increased VEGF in plasma [16], and decreased VEGF in epithelial lining fluid [17], ... expression in lung tissue may contribute to the death of lung epithelial cells Knock-down of either VEGF or VEGFR-1 reduced lung epithelial cell viability To further determine the roles of VEGF and VEGFR-1...

Báo cáo y học: "Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis" pdf

... messages • Increased TREM-1 expression on blood monocytes is an indicator of inflammation but not of infection in patients with AP • Low HLA-DR expression and high IL-6 concentration could predict ... et al Conclusions Increased TREM-1 expression was associated with the presence of inflammation but not infection in AP In patients with AP, low HLA-DR expression and high IL-6 concentration could ... with AP, but this increase was not associated with mortality, or with the presence of infection (a) Triggerin patients with AP, but this increase was not associated with mortality, or with the...

Báo cáo y học: "he adrenocorticotropic hormone-induced cortisol response in acute pancreatitis AB Johan Groeneveld" ppsx

... limitations, the study in Critical Care by Peng and coworkers [1] supports the idea that acute (necrotic/infected) pancreatitis can result in CIRCI following relative adrenal insufficiency, that the ACTH ... interests The author declares that they have no competing interests References Peng Y- S, Wu C-S, Chen Y- C, Lien J-M, Tian Y- C, Fang J-T, Yang C, Chu Y- Y, Hung C-F, Yang C-W, Chen P-C, Tsai M-H: Critical ... Dutch Acute Pancreatitis Study Group: Timing and impact of infections in acute pancreatitis Br J Surg 2009, 96: 267-273 Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty...

Báo cáo y học: " APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial" ppsx

... survival with recombinant human activated protein C treatment in experimental acute pancreatitis Arch Surg 2006, 141:67 0-6 76 Chen P, Zhang Y, Qiao M, Yuan Y: Activated protein C, an anticoagulant ... protein C) in severe acute pancreatitis Crit Care 2005, 9:32 1-3 22 Bradley EL: A clinically based classification system for acute pancreatitis Summary of the international symposium on acute pancreatitis, ... article as: Pettilä et al.: APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial Critical Care 2010 14:R139 Submit your next manuscript to BioMed Central and...

Role of sonic hedgehog signalling in human embryonic stem cells and its neural derivatives

... culture feeding 3.2.3 Human embryonic stem cells and induced pluripotent stem cells Human embryonic stem cell line HES-3 (46, XX) was from ES Cell International (Singapore, http://www.escellinternational.com) ... forebrain, midbrain, hindbrain and the spinal cord This figure was reproduced from Epstein et al., 1999 2.4 SHH and neural development During the initial phase of neural induction, the ectoderm is induced ... Immunoflourescent staining of neural stem cell marker Nestin in SHH-CM and Control-CM treated EB Middle panel shows corresponding DAPI nuclear staining in blue and right panel shows corresponding...

Expression of neurogranin tagged with enhanced green fluorescence protein in HEK293 cells and its effects on neuronal signaling

... A-Ng cells … … … … … … 70 x INTRODUCTION Expression and localization of Neurogranin (Ng) 1.1 Neurogranin cloning, homologs and gene structure Neurogranin is a brain specific, postsynaptic protein ... construction and Ng is inserted between HindIII and BamHI - 39 - PCR using primers containing RE sites HindIII adaptor BamHI adaptor Ng cDNA Digestion with HindIII and Digestion with HindIII and ... amino acid protein The RC3/Ng gene consists of four exons and three introns The first exon contains the entire 5’-untranslated region and those coding for the N-terminal amino acid; the second...

Expression of neurogranin tagged with enhanced green fluorescence protein in HEK293 cells and its effects on neuronal signaling

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