Antigenic diversity of dengue virus implications for vaccine

Antigenic diversity of dengue virus implications for vaccine design

... ANTIGENIC DIVERSITY OF DENGUE VIRUS: IMPLICATIONS FOR VACCINE DESIGN MOHAMMAD ASIF KHAN (B Appl Sc (Hons.) and M.Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... 175 8.1 Antigenic diversity and implications for vaccine design 176 8.2 Strategies for dengue vaccine development . 181 8.3 Vaccine informatics and future vacc...

Ngày tải lên : 11/09/2015, 14:20

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Báo cáo hóa học: " Reemergence of dengue virus type-3 (subtype-III) in India: Implications for increased incidence of DHF & DSS" docx

... outbreak in northern India in 2003 and its continued dominance again in 2004 indicates the resurgence of dengue- 3 in a dominant form The emergence of a newer dengue serotype after an interval ... III) The reemergence of highly fatal subtype III of DEN-3 in a dominant form, replacing the earlier circulating subtype IV of DEN-2 in India is a matter of great concern...

Ngày tải lên : 20/06/2014, 01:20

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Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx

... the process by which host cells repress ICP0- viruses in vivo Therefore, it remains to be determined how ICP0 antagonizes Stat 1dependent repression of HSV-1 Implications for the regulation of ... Stat and lymphocytes are required for a latent HSV-1 infection to be established at the clinically relevant level of the host organism ICP0 antagonizes Stat 1...

Ngày tải lên : 20/06/2014, 01:20

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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development

... B and T cells leading to proliferation and the generation of antibodies (for B cells) and the generation of armed effector T cells such as cytotoxic T cells and helper T cells (Th) (for T cells) ... responses to live and killed bacteria may also provide important insights into the molecular mechanisms of how DC senses microbial pathogens These may hel...

Ngày tải lên : 14/09/2015, 08:24

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A SIRNA SCREEN TO PROBE FOR HYDROXYLASES THAT CAN MODULATE THE REPLICATION OF DENGUE VIRUS

... HYDROXYLASE SIRNA LIBRARY The siARRAY™ protein hydroxylases siRNA library used for the siRNA screen was acquired from Dharmacon The siRNA library was available in a 96-well format and comprised of validated ... based on the mean signal and signal variation (standard deviation) of the positive and negative controls, it takes into account three aspects of a HTS...

Ngày tải lên : 26/09/2015, 09:56

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Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc

... fast-growing area of their off-balance-sheet activities Finally, we examine the implications of the changing nature of banking for ﬁnancial fragility and regulatory policy THE DECLINE OF TRADITIONAL ... been conducted by the Bank for International Settlements (the “Promisel Report”), the Bank of England, the Group of Thirty, the Of ce of the U.S...

Ngày tải lên : 16/02/2014, 11:20

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A Meta-Analysis of Fear Appeals: Implications for Effective Public Health Campaigns pdf

... successes and failures of fear appeals, and fear is reincorporated as a central variable in the model According to the EPPM, the evaluation of a fear appeal initiates two appraisals of the message, which ... defensive avoidance, reactance) outcomes META-ANALYSIS Rationale Meta-analysis is a quantitative method that synthesizes the results of a particular group of s...

Ngày tải lên : 05/03/2014, 22:21

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Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures pot

... |5 Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures | Introduction Exposure to indoor air pollution ... whether the child is carried on the |9 Addressing the Impact of Household Energy and Indoor Air Pollution on th...

Ngày tải lên : 15/03/2014, 16:20

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Báo cáo sinh học: " Peptide inhibitors of dengue virus and West Nile virus infectivity" pot

... mimics of the fusion proteins of other retroviruses, and of orthomyxoviruses, paramyxoviruses, filoviruses, coronaviruses, and herpesviruses have also been identified and shown to inhibit viral ... Figure combination Inhibitory effect of peptides WN53 and DN59 alone and in Inhibitory effect of peptides WN53 and DN59 alone and in combination WN53 and DN59 peptides wer...

Ngày tải lên : 19/06/2014, 08:20

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Báo cáo sinh học: " Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra" ppt

... 0–7 .3 0–6.7 17/7748 31 /10 132 33 /10728 47/14900 46/9 536 52/15496 2.2 3. 1 3. 1 3. 2 4.8 3. 4 3. 3 ± 0.8 4.1 3. 5 6.1 3. 6 6.8 6.5 5.1 ± 1.5 5/17005 16/24165 9/ 232 70 16/2 237 5 25/20585 8/16110 29/ 233 35 32 /30 515 ... ratio in domain III of viral isolates 3H was caused by the value of of dS at the denominator The positive selection on the domain III is not su...

Ngày tải lên : 19/06/2014, 08:20

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Báo cáo hóa học: " An antigenic epitope of influenza virus nucleoprotein (NP) associated with polymeric forms of NP" ppt

... Murti KG: Assembly of influenza virus Ribonucleoprotein in vitro using Recombinant Nucleoprotein Virology 1987, 156:396-403 Ruigrok RW, Baudin F: Structure of influenza virus ribonucleoprotein particles ... neutralization) is also known for influenza virus NP [15] and antigenic epitope depending on NP-NP association probably takes part in this mechanism together with t...

Ngày tải lên : 20/06/2014, 01:20

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Báo cáo hóa học: " Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3" pdf

... among various regions of full- length sequences of different genotypes of DENV-3 With the lack of full- length sequences of viruses belonging to old American genotype IV, only four DENV-3 genotypes, ... http://www.virologyj.com/content/5/1/63 Table 4: Comparison of sequence diversity (p-distance, %) of full- length genomic sequences among different genotyp...

Ngày tải lên : 20/06/2014, 01:20

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Báo cáo hóa học: " Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia" docx

... Ecuador00b I I I I I I I I I I I I I I I I I I I I I I (V)b I (V)b I (V)b II II II II II II II II II II II II II II II III III III III III III III III III III III III III III III III III III III III 1998 ... Asia/S.Pacific (I) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) In...

Ngày tải lên : 20/06/2014, 01:20

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báo cáo hóa học:" Peptide inhibitors of dengue virus and West Nile virus infectivity" doc

... mimics of the fusion proteins of other retroviruses, and of orthomyxoviruses, paramyxoviruses, filoviruses, coronaviruses, and herpesviruses have also been identified and shown to inhibit viral ... Figure combination Inhibitory effect of peptides WN53 and DN59 alone and in Inhibitory effect of peptides WN53 and DN59 alone and in combination WN53 and DN59 peptides wer...

Ngày tải lên : 20/06/2014, 04:20

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báo cáo hóa học:" Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra" doc

... 0–7 .3 0–6.7 17/7748 31 /10 132 33 /10728 47/14900 46/9 536 52/15496 2.2 3. 1 3. 1 3. 2 4.8 3. 4 3. 3 ± 0.8 4.1 3. 5 6.1 3. 6 6.8 6.5 5.1 ± 1.5 5/17005 16/24165 9/ 232 70 16/2 237 5 25/20585 8/16110 29/ 233 35 32 /30 515 ... ratio in domain III of viral isolates 3H was caused by the value of of dS at the denominator The positive selection on the domain III is not su...

Ngày tải lên : 20/06/2014, 04:20

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