Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 2
Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 2
... mitochondrial staining (A) Corresponding histogram of the mitochondrial aggregation (B) n =2 90 LY30 and TRAIL treatment engages the mitochondrial apoptotic pathway The release of apoptogenic factors ... treatment alone was unable to induce the activation of any of the caspases investigated and exposure of HeLa cells to LY30 resulted in minimal caspase activation (less than fold increase) after 6h and ... and Hoescht before analysis by Laser Scanning Cytometry Scattergram representing the area covered by mitochondria against the ratio of the highest mitochondrial staining intensity to the total...
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Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 1
... cleaving lamins [39] and membrane blebbing by targeting proteins such as Rho-associated kinase (ROCK1), p- 21 activated kinase (PAK) and gelsolin [40-42] 1. 2 .1. 2 Inhibitors of apoptosis The IAP ... DISC [11 8] and results in the autocatalytic activation of the initiator caspases [11 9] in accordance with the induced proximity model Activated caspase-8/ -10 in turn targets the effector caspase-3 ... domains [11 5] Alternatively, ligation of TNF-! to TNF-R1 leads to the recruitment of the TNF-R1 Associated Death Domain protein (TRADD) [11 6] TRADD can then recruit FADD Acting as an adaptor...
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Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx
... protein–protein interactions [6], as well as in the structural stability of proteins [23–25] Inspection of a preliminary structural model of cyt c6, based on the known structure of cytochrome c6 from ... oxygen of D72 Taking the functionally and structurally interesting mutant D72K as a material starting point, we aimed to study the contribution of the electrostatic charges at positions D72 and K8 ... traces at the three pH conditions for (A) wild-type ( ), K8A (s), D72A ⁄ K8D (n), D72K ⁄ K8D (,) and D72A ⁄ K8A (e), and for (B) K8D ( ), D72K (s), D72N (n), D72A (,) and D72K ⁄ K8A (e) The lines...
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Báo cáo khoa học: "A Gartner duct cyst of the vagina causing dysuria and dyschezia in a Yorkshire Terrier" pps
... muscle in the lamina propria H&E stain, ×100 (B) High magnification H&E stain, ×1,000 cause dysuria, dyschezia, tenesmus, pain, and dyspareunia can occur with an increase in the size of the cyst ... urinary bladder (UB) and uterus (U) The cyst attached outer wall of cranial vagina (B) There was no connecting between cystic wall (*) and vaginal lumen currence (Fig 3) Analysis of the cystic fluid ... because of the anatomical location adjacent to the uterus and bladder An accurate diagnosis can be obtained by radiography and ultrasonography in order to provide proper treatment In asymptomatic...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R1–YFP – genetic variant of dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein (D1 CFP and D2R2–YFP ... two dopamine D2 receptor fusion proteins (D2 CFP and D2 YFP) f Measured in cell co-expressing two dopamine D2 receptor fusion proteins (D2 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) ... of dopamine D2 receptor) e Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) f Measured in cell co-expressing dopamine...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
... of the Tyr110 -loop in PAL in more detail Tyr -loop in phenylalanine ammonia-lyases Results and discussion Modeling the active conformation of the essential Tyr110 -loop of parsley PAL Because of ... Constructing the ‘Tyr -loop- out’ variants of the bacterial PALs The ‘Tyr -loop- in models PlPALin and SmPALin were modified by replacing residues 50–85 (PlPALin) and 34–68 (SmPALin) with the corresponding ... revealed the greatest divergence in the N-terminal region, which varies greatly in amino acid number and sequence [60], whereas the HAL ⁄ PAL core domain and the C-terminal multi-helix region exhibit...
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WORKING PAPER NO. 218 THE ZERO-INTEREST-RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN potx
... I E S WORKING PAPER NO 218 THE ZERO-INTEREST -RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN * BY GÜNTER COENEN AND VOLKER WIELAND ** MARCH 2003 * Prepared for the “Conference ... Bank working paper series 47 ECB • Working Paper No 218 • March 2003 Abstract In this paper we study the role of the exchange rate in conducting monetary policy in an economy with near-zero nominal ... downward bias in the variability of the real rate depending on the level of the nominal equilibrium rate of interest The downward bias in the variability of the real rate accounts for the reduced...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
... neutrophils, lymphocytes, and eosinophils (b) Section from nasal septum, showing inflammatory infiltrates, fibrin deposition, and erosion of the cartilage Staining with hematoxylin and erythrosine Original ... ones The cytokine interleukin-10 (IL-10) has been in focus for many years in autoimmune arthritis and in other autoimmune diseases The human recombinant protein is currently being tested as a therapeutic ... trachea However, the influence of IL-10 on immune reactivity to CII needs to be further investigated Macrophages were the dominating cell type in the inflammatory infiltrates of laryngeal and nasal...
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THE ROLE OF THE CTD PHOSPHATASE RTR1 AND POST-TRANSLATIONAL MODIFICATIONS IN REGULATION OF RNA POLYMERASE II
... II complex S2 Serine of yeast RNA polymerase II C-terminal domain S2-P Phosphorylated serine of yeast RNA polymerase II C-terminal domain S5 Serine of yeast RNA polymerase II C-terminal domain ... study the RNAPII modifications on both the CTD and the globular core of the enzyme in the presence and absence of Rtr1 IV Mechanisms for RNAPII degradation and recycling pathways RNAPII recycling ... Phosphorylated serine of yeast RNA polymerase II C-terminal domain S7 Serine of yeast RNA polymerase II C-terminal domain S7-P Phosphorylated serine of yeast RNA polymerase II C-terminal domain S cerevisiae...
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investigating the role of the escrt proteins in cytokinesis
... Investigating the role of the ESCRT proteins in cytokinesis Musab Saeed Bhutta B.Sc (Hons) Thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy ... this thesis, the key regulators of cytokinesis, polo kinase and Cdc14 phosphatase, will be described Focus will then turn to the multi-protein complex, the ESCRT proteins Finally, the predominant ... at the spindle midzone and midbody during mitosis and cytokinesis On the other hand, CDC14B is found predominantly in the nucleolus of interphase cells, and then at the spindle apparatus of mitotic...
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Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... expressing gp120/gp41 to proteoliposomes containing CD4 and CCR5 A: Binding of the 35 S-labelled soluble version of gp120/gp41, strain JR-FL to CD 4CCR5 or only CCR5 containing proteoliposomes containing ... polylinker region of the pcDNA3.1myc-His expression vector (Invitrogen, Groningen, the Netherlands) in order to obtain a recombinant protein containing the C-myc epitope followed by six histidines ... histidines at the C-terminus A plasmid containing the wild type version of CCR5 was constructed by introducing the coding sequence of CCR5 between the ApaI and HindIII restriction sites of a pRC-CMV...
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Báo cáo khoa học: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo pptx
... [36,37] The current hypothesis involves domain–domain interactions between the N-terminus and other domains of the ATPase Indeed, in vitro studies of the purified N-terminus and catalytic loop of the ... Wilson ATPase have shown that these two domains interact in the absence of copper and that their interaction is diminished by copper binding to the N-terminus [38] Such a domain–domain interaction ... expressed in Sf9 cells [36,40] It is currently thought that these inhibitory domain–domain interactions are relieved by binding of the metal to the N-terminus of the ATPase To further study the role of...
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Báo cáo khoa học: The catalytic role of the distal site asparagine-histidine couple in catalase-peroxidases potx
... that the rates of compound I formation were reduced to about 10% of the value of native HRP All these findings suggest a similar role of the distal Asn-His couple in planttype peroxidases The present ... conserved distal histidine which is located in the distal cavity and facilitates the deprotonation of H2O2 forming an initial Fe-OOH complex and finally assists in the heterolytic cleavage of the O–O ... protonating the distal oxygen [18] A similar role plays the distal His in KatGs as has been demonstrated recently by site- directed mutagenesis [11,13] It plays a significant role in the distal H-bonding...
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The Rise and Fall of the U.S. Mortgage and Credit Markets: A Comprehensive Analysis of the Meltdown pot
... The Rise and Fall of the U.S Mortgage and Credit Markets A Comprehensive Analysis of the Meltdown James R Barth, Tong Li, Wenling Lu, Triphon Phumiwasana, and Glenn Yago January 2009 A full-length ... financial crisis, along with policy recommendations for moving forward The Rise and Fall of the U.S Mortgage and Credit Markets: A Comprehensive Analysis of the Meltdown will be available online and ... Buildup and Meltdown of the Mortgage and Credit Markets The demand for residential real estate was seemingly insatiable After rising at an average annual rate of slightly less than percent during the...
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CONFLICTS OF INTEREST IN THE HOLLYWOOD FILM INDUSTRY: COMING TO AMERICA - TALES FROM THE CASTING COUCH, GROSS AND NET, IN A RISKY BUSINESS pdf
... Kroo|zrrg lv d qhw0sur wv frqwudfw/ lq zklfk qhw sur wv lv d frqwudfwxdoo| gh qhg whup/ qrw sur w dv fdofxodwhg dffruglqj wr Jhqhu0 doo| Dffhswhg Dffrxqwlqj Sulqflsohv +JDDS,1 Vhyhudo glvsxwhv kdyh dulvhq ... ryhukhdg fkdujhv/ dqg lwv vkduh ri qhw sur wv1 Hdfk frvw frpsrqhqw kdv vrph pdujlq ri sur w fdofxodwhg lqwr lw1 Wkh vwxglr kdv d srwhqwldo frq lfw ri lqwhuhvw ehfdxvh lw pxvw eh wuxvwhg wr shuirup ... wkh qhjdwlyh frvw1 Wkh euhdn0hyhq srlqw ri wzlfh wkh qhjdwlyh frvw zdv fkrvhq ehfdxvh lw zdv fdofxodwhg wr eh wkh srlqw dw zklfk wkh vwxglr zrxog uhfryhu lwv glvwulexwlrq dqg dgyhuwlvlqj h{shqvhv...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP