Investigations on co milling of active pharmaceutical ingredients
Investigations on co milling of active pharmaceutical ingredients
... References……………………………………………………………………………… 163 List of Publications……………………………………………………………………… 196 vi Investigations on Co- milling of Active Pharmaceutical Ingredients SUMMARY Milling is commonly used in pharmaceutical secondary manufacturing ... Energy on Co- milling of CAM…………………… 143 5.4 Milling and Co- milling of IB…………………………………………… 150 5.4.1 Effect of...
Microfluidic methods for the crystallization of active pharmaceutical ingredients
... which the further growth of the cluster results in a reduction of overall free energy Such clusters then tend to grow spontaneously [22], [23] The rate of formation of these clusters - the rate of ... stable ones in the solid state [44] or in the presence of solvent [45], the prevention of which is of paramount importance in the final formulation of solid dosa...
Understanding dynamics in thin film spherical crystallization of active pharmaceutical ingredients from microfluidic emulsion
... standard Teflon microfluidic tubing connected to the syringe pumps (not shown on figure) 17 Understanding Dynamics in Thin- Film Evaporation of Microfluidic Emulsions for Spherical Crystallization ... Assembly of Microfluidic Device 11 1 2 3 4 5 10 11 12 15 15 15 17 Understanding Dynamics in Thin- Film Evaporation of Microfluidic Emulsions for Spherical...
Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... a deletion in region II (Fig 4A) demonstrated the essential role of this region in the transcription of the Ig-b gene Deletion of region III decreased the expression of Ig-b mRNA to 40% of the ... maintenance of active chromatin state in the Ig-b locus were examined in the deletion cells Establishment and maintenance of active...
Investigations on the immunopathology of enterovirus 71 1
... of EV 71 strains 18 4 CHAPTER CONCLUSION AND FUTURE WORK 19 2 7 .1 ROLE OF INTERLEUKIN-6 IN THE IMMUNOPATHOGENESIS OF EV 71 INFECTION 19 2 7.2 ROLE OF DC IN EV 71 INFECTION ... Distribution of EV 71 isolates identified globally from 19 70 to 2000 16 Figure 1. 4 Distribution of inflammation in brain sections of EV 71 patients 23 Figure 1. 5 The postulated pathol...
Investigations on the immunopathology of enterovirus 71 3
... percentage composition per spleen The dotted line indicates the highest amount or percentage of cells observed for the two fatal strains (B) Specific anti-EV71 IgM and IgG titers in sera of infected ... CHAPTER INVESTIGATIONS ON EV71 VIRULENT DETERMINANTS B Figure 6.5 Adaptive immune response in EV71-infected AG129 mice (A) Two-week-old mice were infected ... (n=5) were euthaniz...
Investigations on the immunopathology of enterovirus 71 2
... well as the effects of the systemic inflammatory response on the vascular endothelium The key to further decipher the exact mechanisms for PE in EV71 encephalitis relies on the development of more ... observed (Shieh et al, 20 01; Yang et al, 20 09) 22 CHAPTER LITERATURE REVIEW Figure 1.4 Distribution of inflammation in brain sections of EV71 patients (A) Whole brai...
Investigations on the immunopathology of enterovirus 71 4
... CHAPTER CONCLUSION One limitation of the present study is the use of neonatal mice as animal model IL-6 functions mainly as the inducer of acute-phase response and T- and B-cell stimulation Given the ... throughout the course of infection While we could not entirely rule out the contribution of myositis to EV71-induced disease manifestations, our results suggest that th...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the s...
Investigations on the toxicity of nanoparticles
... + Oxidationm-n- 1.3 Equation 1.3 depends on the thermodynamics of the process, which in turn is represented by the electrochemical potentials of the corresponding half cell reactions These are ... stability of the particles Agglomeration of the nanoparticles will yield particles of size in the micron range, skewing data interpretation The commercially available...
Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate specificity docx
... catalytic residues: E52 and R105 It is evident from the kinetic results that mutation of E52 changes only the catalytic rate For the E52D mutant the Km value was approximately the same as for the wild-type ... mutation of deoxyribonucleoside kinase L Egeblad-Welin et al Human deoxyribonucleoside kinases are targets for the chemotherapeutic treatment of...
Báo cáo khoa học: Protective effect of active oxygen scavengers on protein degradation and photochemical function in photosystem I submembrane fractions during light stress pdf
... the degradation of each polypeptide and the protein conformation changes are assessed in connection with alterations in photochemical activity during strong light illumination of the PSI submembrane ... Lhca1 and Lhca2 is due to generation of reactive oxygen species during strong light illumination which leads to some alteration in the Chl protein interactio...