Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications

... underlying this is unclear Genomic instability in cancer is broadly categorized into mutational instability, e.g., microsatellite instability (MIN) and chromosome instability (CIN) CIN, characterized ... 13% of patients In addition inactivating mutations of TRAF2, cIAP1/2, and CYLD were identified Chromosome translocations and amplifications resulting in activation of NFB...

Ngày tải lên: 11/09/2015, 09:58

... understanding of MetS The insulin receptor has an intrinsic tyrosine kinase activity Binding of insulin to its receptor induces both autophosphorylation and phosphorylation of tyrosine residues on insulin ... the insulin receptor and/ or IRS proteins, whereas the MAP kinase pathway remains open and may even be hypersensitive [10] Inflammatory cytokines and insulin resistance Inflammato...

Ngày tải lên: 09/08/2014, 10:23

... Relatively easy to incorporate into routine nursing care Attempts to qualify wake, non-rapid eye movement, and rapid eye movement sleep Advantages Summary of methods used in critical care for sleep measurement ... those pertaining to sleep measurement in adult patients during their critical care admission and published in full in English Study comparing differe...

Ngày tải lên: 13/08/2014, 08:20

... DEX and this action seems mainly involving pathways regulating ROS in MM cells Whether this finding will help in reducing DEX toxicity or improving its efficacy particularly in combination with ... leukemic cells and primary thymocytes [13] We show that TXNIP-ROS-TRX axis is functional in response to glucose in out of MM cell lines tested and TXNIP RNA level is responsive...

Ngày tải lên: 10/08/2014, 10:21

... Bidirectional Signalling of the CD137: CD137L System 16 1.9 CD137/ CD137L in Tumor Immunotherapy 19 1.10 Multiple Myeloma and the CD137: CD137L System 23 1.11 Multiple Myeloma and Follicular ... rendering it obsolete Published by the International Myeloma Working Group in 2005, the International Staging System (ISS) for multiple myeloma relies mainly on the de...

Ngày tải lên: 26/09/2015, 10:59

... detection in gases and liquids, flue gas and fire detection, liquid quality sensors, biosensors and medical sensors Some of the major applications in the home include indoor air quality and natural gas ... available hand-held wireless transmitter to realize a portable, fast and high sensitive CO2 sensor 2.4 CH4 sensing Of particular interest in developing wide bandgap...

Ngày tải lên: 20/03/2014, 13:06

... evaluating consensus regions in multiple aligned protein sequences This paper presents an outline of the segmentation algorithm (see Yan [10]) for multipattern consensus regions in aligned protein sequences, ... overlapping regions Gap exists between some regions The result shows that the positions of the p53 sequences form clear regions There are D -regions...

Ngày tải lên: 22/06/2014, 22:20

... fragments Noncollagen and nonaggrecan proteins Cartilage oligomeric matrix protein Type I collagen Pyridinoline, deoxypyridinolin PYD, DPD Type I collagen C-terminal and N-terminal telopeptides CTX-I, ... Activity Index (reviewed in [9]) – have been shown useful for following disease activity and for serving as endpoints in clinical trials and observational studies [72,73] M...

Ngày tải lên: 09/08/2014, 10:23

... of a variety of models, including CIA and several murine lupus models Clinical trials directly targeting IL-21 are in pre -clinical planning at this time The therapeutic utility of this cytokine ... presentation by Novartis at the ACR Annual Scientific Meeting 2008) The results of other ongoing clinical trials targeting IL-17 will certainly increase our understanding o...

Ngày tải lên: 09/08/2014, 14:20

... relapsed disease after autologous stem cell transplantation The presence of circulating plasma cells and hyperammonemia are both known to be indicators of advanced disease Plasma cell neoplasm should ... M, Hanafusa T: Pulmonary parenchymal infiltrates in a patient with CD20-positive multiple myeloma European Journal of Haematology 74:61-65 Freeman Z: Myelomatosis with extensi...

Ngày tải lên: 10/08/2014, 22:20

... W74V8H-06-C-0002 Library of Congress Cataloging -in- Publication Data How domestic trends in the U.S., China, and Iran could influence U.S Navy strategic planning / John Gordon IV [et al.] p cm Includes ... trends in the United States, the People’s Republic of China (PRC), and Iran The Navy is interested in these countries’ likely “resource drivers”...

Ngày tải lên: 23/03/2014, 02:20

... domain Because WD40 domain is involved in mediating protein–protein interactions, the LRRK2 G2385R variant may impact on interactions with substrates and ⁄ or regulatory proteins Preliminary studies ... Genetic and clinical studies of LRRK2 U Kumari and E K Tan cal hallmarks are characterized by a progressive and profound loss of neuromelanin-containing dopaminergic neur...

Ngày tải lên: 23/03/2014, 04:20

... arthritis may be induced by systemic autoreactivity remains interesting and plausible G6PIinduced arthritis provides a model in which both the induction and modulation of arthritis induced by autoreactivity ... autoreactivity against the ubiquitously expressed glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune dis...

Ngày tải lên: 09/08/2014, 06:22