Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques

... of an in-depth examination of the biology of acute myeloid leukemia, the drugs rapamycin and genistein, and an evaluation of the advantages of combining high- throughput approaches and functional ... a long period of time On the one hand, the risk factors include heredity, abnormal genetic regulation and genetic makeup of some individuals On the...

Ngày tải lên: 11/09/2015, 09:18

... In vitro and In vivo study of ABT- 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism and biologic characterization ... target of STAT3 3.3.9 In vivo efficacy of IDR E804 in combination with ABT- 869 for treatment of MV4-1...

Ngày tải lên: 11/09/2015, 09:06

... [20] In the current study, no NPM1 mutations were detected in cases with secondary AML following MDS, which is in line with previous studies associating absence or low rates of NPM1 mutations in ... Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia Med Oncol 2009, 26:460-462 Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U: Different...

Ngày tải lên: 10/08/2014, 22:21

... Leukemias Blood 2009, 114: Abstract No.1039 doi: 10.1186/1756-8722-3-17 Cite this article as: Zhu et al., Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights ... cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B Blood 1991, 78:2520-2526 Larson RA: Is modulation of multidrug resistance a...

Ngày tải lên: 10/08/2014, 22:21

... Beer and others to the outskirts of Tokyo Another major factor was the reduction of water use in the factory through the utilization of WWR and water conservation efforts mainly due to their cost ... rice and the washings would later be used for watering plants to utilize the remaining nutrients Likewise, making the most of rainwater by RWH should be t...

Ngày tải lên: 05/09/2013, 10:17

... Assessment of the effects and limitations of the 1998 to 2008 Abbreviated Injury Scale map using a large population-based dataset Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine ... AIS08 mapping, and potentially the accuracy of the ISS calculation, in 33.0% of study patients and prevented the calculation of any ISS va...

Ngày tải lên: 13/08/2014, 23:20

... represented in the AML samples Intra-individual analysis of the spot patterns showed a high correlation between the sample from peripheral blood and bone marrow (Table 2) On/off-phenomena of the identified ... Expression of the plasminogen activator inhibitor-2 (PAI2) was only found in patients E and F with the subtyp FAB M0 and M4, respectively T...

Ngày tải lên: 18/06/2014, 15:20

... loading Results BPA induces dose dependent apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three ... activity of these compounds [17,18] In the present manuscript, we decided to investigate the effects of different doses of BPA on acute myeloid l...

Ngày tải lên: 18/06/2014, 15:20

... with the same magnitude of activity, low activity in the morning and high activity in the afternoon, their average activity may be similar, and a significant difference in circadian activity patterns ... on circadian activity patterns using functional linear modeling of actigraphy data Journal of Circadian Rhythms 2011 9:11 Authors’ contributio...

Ngày tải lên: 10/08/2014, 09:20

... Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications Journal of Hematology & Oncology 2011 4:13 Submit your next manuscript ... The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and be...

Ngày tải lên: 10/08/2014, 21:23

... A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome Guoqing Wei1,2, ... Efficacy of induction chemotherapy for patients with high-risk myelodysplastic syndrome (MDS) or MDS-transformed acute myeloid leukemia with CHG regimen and...

Ngày tải lên: 10/08/2014, 21:23

... depending on the differentiation direction and degree of maturation 1.2 Acute Promyelocytic Leukemia (APL) Acute promyelocytic leukemia (APL) accounts for 10 – 15 % of acute myeloid leukemia (AML) and ... 3.3.2 Anti-proliferative activity of curcumin and analogs on leukemic non-APL cell lines 91 3.3.3 Anti-proliferative activity of curcumin and...

Ngày tải lên: 11/09/2015, 14:20

... Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational ... DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ primary AML samples We showed that curcumin selective...

Ngày tải lên: 18/06/2014, 19:20

... checked by indirect enzyme-linked immunosorbent assay (ELISA), myeloma cells line SP2/0 (106) were fused with splenocytes (107) by the addition of 45% polyethylene glycol (PEG-4000) Hybridomas ... may detect the NPM-wt existing in the cytoplasm and cause false positives In this study, we analyzed the antigen epitope of NPM-mA protein and confirmed it may exist in the C-terminal...

Ngày tải lên: 08/08/2014, 18:21