Asymmetric organocatalytic conjugate additions with vinyl sulfones
Asymmetric organocatalytic conjugate additions with vinyl sulfones
... Used in Conjugate Additions 15 1.5 Asymmetric Conjugate Adddition to Vinyl Sulfones 18 1.5.1 Enamine-Based Conjugate Additions to Vinyl Sulfones 18 1.5.2 Conjugate Addition to Vinyl Sulfones ... α-cyano vinyl sulfones 22 Scheme 1-20 Asymmetric conjugate additions of α-chloro aldehydes to vinyl sulfone 22 Scheme 1-21 Facial conversions to vinyl sulfone a...
Ngày tải lên: 11/09/2015, 09:17
Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions 2
... deprotonation/deuteriation process 2. 2 Enantioselective H/D exchange of -fluorinated aromatic ketones 2. 2.1 Synthesis of -fluorinated aromatic cyclic ketones and chiral bicyclic guanidine catalyst ... much (entries 12- 13) Table 2. 1 Optimization of the asymmetric H/D exchange reaction of -fluorinated ketone 82a in different conditions (Scheme 2. 6) incorporation en...
Ngày tải lên: 10/09/2015, 15:51
Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions 4
... 3.7 Asymmetric amination reation of -fluorinated aromatic cyclic ketone Scheme 3.8 Other -fluorinated compounds tested in asymmetric amination a Conversion of corresponding products determined ... cyclic ketone nucleophiles in asymmetric amination reaction catalyzed by chiral bicyclic guanidine Under the optimal reaction conditions, the chiral -hydrozino- -fluorinated...
Ngày tải lên: 10/09/2015, 15:51
Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions 4a
... -fluorinated aromatic ketones in the asymmetric Mannich and Michael reactions 4.2 Asymmetric Mannich reaction of -fluorinated aromatic ketones 4.2.1 Synthesis of imines and pentanidines; Pentanidines ... Enatioselective C- C bond formation 4.1 Introduction Asymmetric C- C bond formation reactions are important reactions in organic synthesis Among the variou...
Ngày tải lên: 10/09/2015, 15:51
Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions 5
... 121 Experimental Colorless oil LRMS (ESI) m/z 55 1.3 (M+Na+); 5. 5 Protocol for bicyclic guanidine catalyzed asymmetric C- C bond formation reactions and characterization of products Procedures for ... 254 nm; retention time: major isomer: 124.3 min; minor isomer: 132.8 5. 4 Protocol for bicyclic guanidine catalyzed asymmetric C- N bond formation reaction and characteriza...
Ngày tải lên: 10/09/2015, 15:51
Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions
... asymmetric conjugated addition reactions Most aliphatic ketone and acetophenone nucleophiles used in organocatalytic asymmetric transformations rely on the formation of highly reactive enamine intermediates.1 ... basic phase-transfer conditions We will describe the asymmetric H/D exchange reaction, C- N and C- C bonds formation reactions catalyzed by our guanidin...
Ngày tải lên: 10/09/2015, 15:51
ASYMMETRIC ORGANOCATALYTIC HENRY REACTION OF ß¿SUBSTITUTED a KETO ESTERS VIA DYNAMIC KINETIC RESOLUTION
... cinchona alkaloid derived bifunctional catalysts Our approach combines organocatalytic Henry reaction and concept of dynamic kinetic resolution, and it also provides an access to biologically important ... cinchona alkaloid derivatives as catalysts In this process, (DHQD)2AQN 1-25 acts as a bifunctional catalyst to catalyze both racemization and alcoholytic kinetic resolutio...
Ngày tải lên: 30/09/2015, 14:23
Organocatalytic conjugate addition reactions
... Michael reactions of hydroxycarbamates 156a with different Michael acceptors List of Figures Fig 1.1 Publications for asymmetric organocatalytic conjugate additions and organocatalytic reactions ... quaternary ammonium catalyzed conjugate addition Scheme 1.2 Mukaiyama’s chiral quaternary ammonium phenoxide catalyzed conjugate addition in a tandem Mukaiyama-Michael addition...
Ngày tải lên: 16/10/2015, 15:35
Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc
... evolution of the ChEs, including the origins of the acyl pocket, the T exon, and the asymmetric forms of ChE in the vertebrates Results The sequence of the ChE from C intestinalis suggests that the ... other invertebrates, there is a deletion in the region of the acyl pocket of C intestinalis compared to the vertebrate enzyme (Fig 1) Additiona...
Ngày tải lên: 18/02/2014, 17:20
Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc
... understood process Both saporin and anticancer saporin conjugates enter the target cell by endocytosis and then escape the endomembrane system to reach their cytosolic target [7–11] Other toxins that ... corresponded to lipopolyamine transfection efficiency was documented for saporin intoxication Lipopolyamine treatment enhances the potency of uPA -saporin, an an...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo hóa học: " Abstract Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor." ppt
... integrated into the standard of care regime [5,52-54] The number of slots open for patient accrual to the immunotherapy protocols contained in our list of open trials totals 489 Based upon the 2010 ... cytotoxic effector cells to the patient is categorized as a form of passive immunotherapy The effector cells are administered either systemically or intracranial...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo sinh học: " Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity" ppt
... carrying operators 5'GGTGGATGTCAAG and 5'GGTGGCTGTCAAG as O64 and OL, respectively, and shown that CI binds to former operator more strongly than latter operator Interestingly, repressor- operator ... but also to stop the elongation of L5 transcripts Additional studies reveal that affinity of CI to an L1 operator (5'GGTGGCTGTCAAG) decreases notably at 42°C compare...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo hóa học: " Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity" ppt
... carrying operators 5'GGTGGATGTCAAG and 5'GGTGGCTGTCAAG as O64 and OL, respectively, and shown that CI binds to former operator more strongly than latter operator Interestingly, repressor- operator ... but also to stop the elongation of L5 transcripts Additional studies reveal that affinity of CI to an L1 operator (5'GGTGGCTGTCAAG) decreases notably at 42°C compare...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo toán học: " Modeling bee swarming behavior through diffusion adaptation with asymmetric information sharing" pptx
... 1 Modeling bee swarming behavior through diffusion adaptation with asymmetric information sharing Jinchao Li and Ali H Sayed Department ... article studied the modeling capabilities of diffusion adaptation mechanisms in the context of bee swarming Bee swarms provide an example of mobile networks with asymmetric flow of information where ... bees arise from...
Ngày tải lên: 20/06/2014, 20:20
Báo cáo hóa học: " Modified nonlinear conjugate gradient method with sufficient descent condition for unconstrained optimization" pptx
... 1.2177 1.2186 VLS method DSP−CG method PRP method CG DESCENT method 0.9 0.8 0.7 Y 0.6 0.5 0.4 0.3 0.2 0.1 0 10 X Figure Performance profiles of the conjugate gradient methods with respect to CPU ... conjugate gradient method and its global convergence IMA J Numer Anal 26, 629–640 (2006) doi:10.1093/imanum/drl016 16 Yuan, G: modified nonlinear conjugate gradient m...
Ngày tải lên: 20/06/2014, 22:20